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PCSK9[Biotinylated]-LDLR Binding Assay Kit
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Cat.No. : | Kit-1807 |
Product Overview : | PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. |
Size : | 96 reactions |
Applications : | Great for screening small molecules and antibodies that inhibit the binding of PCSK9 to LDLR ectodomain. |
Storage : | Mixed storage conditions. Stable at least 12 months from date of receipt, when stored as directed |
◆ Recombinant Protein
PCSK9-812M | Recombinant Mouse PCSK9 Protein (Met1-Gln694), MlgG1 Fc-tagged | +Inquiry |
PCSK9-01H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
Pcsk9-020M | Recombinant Mouse Pcsk9 Protein, MYC/DDK-tagged | +Inquiry |
PCSK9-005H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-03H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
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◆ Lysates
PCSK9-2775RCL | Recombinant Rhesus PCSK9 cell lysate | +Inquiry |
PCSK9-2564MCL | Recombinant Mouse PCSK9 cell lysate | +Inquiry |
PCSK9-2875HCL | Recombinant Human PCSK9 cell lysate | +Inquiry |
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◆ Assay kits
Kit-1808 | PCSK9-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1806 | PCSK9(D374T)-LDLR TR-FRET Assay Kit | +Inquiry |
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