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Specification Related Products

Cat.No. :	Kit-1807
Product Overview :	PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.
Size :	96 reactions
Applications :	Great for screening small molecules and antibodies that inhibit the binding of PCSK9 to LDLR ectodomain.
Storage :	Mixed storage conditions. Stable at least 12 months from date of receipt, when stored as directed