PDE4C Assay Kit
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Cat.No. : | Kit-1840 Optional Service: Optional requirements on this protein |
Product Overview : | Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE4C selectively hydrolyzes cAMP and is a candidate biomarker for human glioma. Research suggests that PDE4C functions as a tumor suppressor, and downregulation of PDE4C in glioma patients correlates with poor prognosis. |
Size : | 384 reactions |
Description : | The PDE4C1 Assay Kit is designed for identification of PDE4C1 inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE4C1 to the binding agent. The key to the PDE4C1 Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE4C1 reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE4C1 for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader. |
Applications : | Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications. |
Storage : | At least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival. |
◆ Recombinant Protein
Pde4c-470M | Recombinant Mouse Pde4c Protein, MYC/DDK-tagged | +Inquiry |
PDE4C-6585M | Recombinant Mouse PDE4C Protein, His (Fc)-Avi-tagged | +Inquiry |
PDE4C-477H | Recombinant Human PDE4C, GST-tagged, Active | +Inquiry |
PDE4C-2481H | Recombinant Human PDE4C protein, His-tagged | +Inquiry |
PDE4C-1600H | Recombinant Human PDE4C, GST-tagged | +Inquiry |
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◆ Lysates
PDE4C-3351HCL | Recombinant Human PDE4C 293 Cell Lysate | +Inquiry |
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Pde10aPDE11APDE1APDE1BPde1cPDE2APDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE6BPDE6CPDE6DPDE7APDE7BPDE8APDE9APDE4DIPPDE12PDE6APDE8BPDE6GPDE6H
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