Recombinant Anti-Human IL 12B Monoclonal Antibody
Cat.No. : | CAB-T9002H |
Product Overview : | Mab to IL12B. Recombinant monoclonal antibody to Human IL 12B. |
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Cat. No. : | CAB-T9002H |
Antigen Description : | Cytokine that can act as a growth factorfor activated T and NK cells, enhance the lytic activity ofNK/lymphokine-activated Killer cells, and stimulate the production ofIFN-gamma by resting PBMC. |
Protein Costruction : | DNA sequences codingH and L chains of Anti-human interleukin-12/23 monoclonal antibody cotransfected to host cell were expressed. |
Isotype : | IgG |
Formulation : | Normally 1mg/mlL-His, 1mg/ml Sucrose and 0.04 mg/ml Tween-80 are added, pH 6.0. Pleasecontact us for any concerns or special requirements. |
Purity Detail : | >95% asdetermined by SDS-PAGE and HPLC |
Source : | Culture Supernatant |
Expression Host : | Chinese HamsterOvary (CHO cell) |
Endotoxin : | <1.0EUper 10 mg protein as determined by the LAL method |
Molecular Mass : | The secretedrecombinant Anti-human interleukin-12/23 monoclonal antibody comprises 1326amino acids. As a result of glycosylation, it has molecular mass of 150kDa inSDS-PAGE under non-reducing conditions. |
Predicted N terminal : | H chain: EVQLVQSGAE;Lchain:DIQMTQSPSS |
Stability : | Samples are stablefor up to twelve months from date of receipt at -20°C and are stable forsix months at 4°C. |
Storage : | Store it understerile conditions at -70°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage. |
Background : | The recombinant antibody targets the epitope of IL12. Like Briakinumab or ustekinumab,whichis directed against interleukin 12 naturally occurring proteins that regulatethe immune system and immune-mediated inflammatory disorders. Anti-humaninterleukin-12/23 monoclonal antibody is a human IgG1 monoclonal antibodythat binds to subunit of p40, which is used by IL-12 and IL-23. It isproduced in Chinese hamster ovary (CHO) cells. |
Tag : | Non |
Gene Name : | IL12B interleukin 12B(natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturationfactor 2, p40) [ Homo sapiens ] |
Official Symbol : | IL12B |
Synonyms : | IL12B; CLMF; NKSF; CLMF2; NKSF2; IL-12B;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxiclymphocyte maturation factor 2, p40); interleukin-12 subunit beta CLMF p40; IL-12 subunit p40; IL12, subunit p40; OTTHUMP00000160820;interleukin 12, p40; interleukin-12 beta chain; NK cell stimulatory factorchain 2; cytotoxic lymphocyte maturation factor 40 kDa subunit; naturalkiller cell stimulatory factor, 40 kD subunit |
Gene ID : | 3593 |
mRNA Refseq : | NM_002187 |
Protein Refseq : | NP_002178 |
MIM : | 161561 |
UniProt ID : | P29460 |
Chromosome Location : | 5q31.1-q33.1 |
Pathway : | African trypanosomiasis, organism-specific biosystem; Africantrypanosomiasis, conserved biosystem; Allograft rejection, organism-specificbiosystem; Allograft rejection, conserved biosystem; Amoebiasis,organism-specific biosystem; Amoebiasis, conserved biosystem; Chagas disease(American trypanosomiasis), organism-specific biosystem; Chagas disease (Americantrypanosomiasis), conserved biosystem; Cytokine-cytokine receptorinteraction, organism-specific biosystem; Cytokine-cytokine receptorinteraction, conserved biosystem; Cytokines and Inflammatory Response,organism-specific biosystem; |
Function : | contributes_tocytokine activity; cytokine receptor activity; contributes_to growth factoractivity; identical protein binding; interleukin-12 alpha subunit binding; interleukin-12receptor binding; contributes_to interleukin-12 receptor binding; contributes_tointerleukin-23 receptor binding; protein binding; protein heterodimerizationactivity; protein homodimerization activity; signal transducer activity |
Products Types
◆ Lysates | ||
IL12B-2731HCL | Recombinant Human IL12B cell lysate | +Inquiry |
IL12B-1197RCL | Recombinant Rat IL12B cell lysate | +Inquiry |
IL12B-1000MCL | Recombinant Marmoset IL12B cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewGood for cytokine assays.
Effective in Th2 cell differentiation.
High yield in expression.
Q&As (10)
Ask a questionChIP-seq identifies regulatory elements controlling IL12B gene expression.
Reporter assays monitor IL12B promoter activity under varying conditions.
Primary cell stimulation assays gauge IL12B response to pathogens.
siRNA knockdown uncovers IL12B's role in immune cell activation pathways.
Recombinant protein expression enables functional IL12B studies in vitro.
Co-IP validates IL12B's binding to specific signaling partners.
Genetic variant analysis reveals impacts on IL12B protein function.
Flow cytometry profiles IL12B expression across diverse immune cell types.
Cytokine secretion assays measure IL12B's response kinetics to stimuli.
Co-IP and immunoprecipitation assess IL12B's interactions with other proteins.
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