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Recombinant Anti-Human IL 12B Monoclonal Antibody

Cat.No. : CAB-T9002H
Product Overview : Mab to IL12B. Recombinant monoclonal antibody to Human IL 12B.
  • Specification
  • Gene Information
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Cat. No. : CAB-T9002H
Antigen Description : Cytokine that can act as a growth factorfor activated T and NK cells, enhance the lytic activity ofNK/lymphokine-activated Killer cells, and stimulate the production ofIFN-gamma by resting PBMC.
Protein Costruction : DNA sequences codingH and L chains of Anti-human interleukin-12/23 monoclonal antibody cotransfected to host cell were expressed.
Isotype : IgG
Formulation : Normally 1mg/mlL-His, 1mg/ml Sucrose and 0.04 mg/ml Tween-80 are added, pH 6.0. Pleasecontact us for any concerns or special requirements.
Purity Detail : >95% asdetermined by SDS-PAGE and HPLC
Source : Culture Supernatant
Expression Host : Chinese HamsterOvary (CHO cell)
Endotoxin : <1.0EUper 10 mg protein as determined by the LAL method
Molecular Mass : The secretedrecombinant Anti-human interleukin-12/23 monoclonal antibody comprises 1326amino acids. As a result of glycosylation, it has molecular mass of 150kDa inSDS-PAGE under non-reducing conditions.
Predicted N terminal : H chain: EVQLVQSGAE;Lchain:DIQMTQSPSS
Stability : Samples are stablefor up to twelve months from date of receipt at -20°C and are stable forsix months at 4°C.
Storage : Store it understerile conditions at -70°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background : The recombinant antibody targets the epitope of IL12. Like Briakinumab or ustekinumab,whichis directed against interleukin 12 naturally occurring proteins that regulatethe immune system and immune-mediated inflammatory disorders. Anti-humaninterleukin-12/23 monoclonal antibody is a human IgG1 monoclonal antibodythat binds to subunit of p40, which is used by IL-12 and IL-23. It isproduced in Chinese hamster ovary (CHO) cells.
Gene Name : IL12B interleukin 12B(natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturationfactor 2, p40) [ Homo sapiens ]
Official Symbol : IL12B
Synonyms : IL12B; CLMF; NKSF; CLMF2; NKSF2; IL-12B;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxiclymphocyte maturation factor 2, p40); interleukin-12 subunit beta CLMF p40; IL-12 subunit p40; IL12, subunit p40; OTTHUMP00000160820;interleukin 12, p40; interleukin-12 beta chain; NK cell stimulatory factorchain 2; cytotoxic lymphocyte maturation factor 40 kDa subunit; naturalkiller cell stimulatory factor, 40 kD subunit
Gene ID : 3593
mRNA Refseq : NM_002187
Protein Refseq : NP_002178
MIM : 161561
UniProt ID : P29460
Chromosome Location : 5q31.1-q33.1
Pathway : African trypanosomiasis, organism-specific biosystem; Africantrypanosomiasis, conserved biosystem; Allograft rejection, organism-specificbiosystem; Allograft rejection, conserved biosystem; Amoebiasis,organism-specific biosystem; Amoebiasis, conserved biosystem; Chagas disease(American trypanosomiasis), organism-specific biosystem; Chagas disease (Americantrypanosomiasis), conserved biosystem; Cytokine-cytokine receptorinteraction, organism-specific biosystem; Cytokine-cytokine receptorinteraction, conserved biosystem; Cytokines and Inflammatory Response,organism-specific biosystem;
Function : contributes_tocytokine activity; cytokine receptor activity; contributes_to growth factoractivity; identical protein binding; interleukin-12 alpha subunit binding; interleukin-12receptor binding; contributes_to interleukin-12 receptor binding; contributes_tointerleukin-23 receptor binding; protein binding; protein heterodimerizationactivity; protein homodimerization activity; signal transducer activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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