IL12B
-
Official Full Name
interleukin 12B
-
Background
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. -
Synonyms
40 kD Subunit; CLMF 2; CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 2; Cytotoxic lymphocyte maturation factor 2 p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; HGNC:5970; IL 12 subunit p40; IL 12B; IL-12 subunit p40; IL-12B; IL12 subunit p40; IL12B; IL12B_HUMAN; Interleukin 12 p40; Interleukin 12 subunit beta; Interleukin 12B; Interleukin-12 subunit beta; Interleukin12B; NK cell stimulatory factor chain 2; NKSF; NKSF2; p40; IL12 p40-Carboxyterminal end;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL12B Related Articles
- IL12B Related Gene Family
- IL12B Related Research Area
- IL12B Related Signal Pathway
IL12B involved in several pathways and played different roles in them. We selected most pathways IL12B participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CSF1RA;CCL4L2;IFNA17;TNFRSF10B;LOC100033925;THPO;Ifnlr1;PDGFRB;CCL4 |
| Toll-like receptor signaling pathway | Ifna11;IFNPHI3;MAP2K4A;IFNA1;IFNA2;CXCL8B.3;SPP1;MAPK3;MAPK1 |
| RIG-I-like receptor signaling pathway | OTUD5A;IL12B;IFNA2;MAPK14A;TRAF6;IFNA17;MAPK8;MAPK13;MAPK12A |
| Jak-STAT signaling pathway | CRFB4;IL2RB;Ifna11;IL10RB;CSH1;IL15RA;STAT3;IL27RA;IFNA16 |
| Type I diabetes mellitus | CPE;GZMB;HLA-A;CD80;H2-AA;INS1;HLA-DMA;HLA-DOB;HLA-DPA1 |
| Pertussis | IL-8;IRAK1;TLR4;IL12A;MYD88;MAPK3;Hc;CXCL5;NLRP3 |
| Legionellosis | CASP1;HSPA8;ITGB2;IL18;NAIP1;CR1;EEF1A1;CASP9;BNIP3 |
| Leishmaniasis | NOS2;FCGR3A;NFKB1;FCGR1A;HLA-DPA1;TAB2;MARCKSL1;IFNGR2;IFNGR1 |
| Chagas disease (American trypanosomiasis) | CCL2;GNAS;CCL3L3;GNAI2;GNA11;C1QC;GNAI1;NOS2;PLCB3 |
| African trypanosomiasis | VCAM1;HBA-A2;LAMA4;HBB-B1;THOP1;PRKCB;PRKCA;GNAQ;IDO1 |
| Toxoplasmosis | LAMA2;PIK3R3;LAMA4;Toxoplasma Gondii Profilin Family Protein;LAMA1;HLA-DOA;HLA-DMA;H2-AB1;HLA-DRB1 |
| Amoebiasis | IL1B;PIK3R1;RAB7;COL2A1;PRKACG;GM-CSF;PIK3R2;SERPINB13;CD1d1 |
| Tuberculosis | ATP6V0A1;IL23;ATP6V0A2;LAMP1;HLA-DRB3;TRAF6;IRAK4;STAT1;CAMK2A |
| Measles | IFNAR2;IFNA4;STAT3;IFNG;CD209A;PIK3CB;CD3G;IL6;IFNA2 |
| Influenza A | TMPRSS4;TNFSF10;HNRNPUL1;BCL2L2-PABPN1;PRSS3;TNF;IVNS1ABP;HLA-DQA2;FASLG |
| Herpes simplex infection | IRF7;SRSF2B;MAP3K7;RELA;BLB1;HLA-DQA2;IFNA13;CFP;HLA-DRB3 |
| Proteoglycans in cancer | PRKACG;WNT2B;HCLS1;PPP1R12B;WNT6;TFAP4;CCND1;CDC42;NUDT16L1 |
| Inflammatory bowel disease (IBD) | Il23a;FOXP3;RELA;IL4R;IFNG;HLA-DPA1;IL12B;TGFB1;HLA-DRB5 |
| Allograft rejection | IL10;HLA-F;H2-Q10;IL5;HLA-DQA1;IFNG;IL12A;HLA-DMB;HLA-DRA |
IL12B has several biochemical functions, for example, contributes_to cytokine activity, cytokine receptor activity, contributes_to growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12B itself. We selected most functions IL12B had, and list some proteins which have the same functions with IL12B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to cytokine activity | CRLF1;IL12A;CLCF1;IL12B |
| cytokine receptor activity | GHR;Ifnlr1;IL11RA;CRFB16;IL20RB;LIFRA;CRFB12;IL4R.1;IL13RA1 |
| contributes_to growth factor activity | IL12B;IL12A |
| identical protein binding | CLDN17;PAFAH1B3;SNCA;GCC2;CBLL1;PPP5C;HAPLN2;IRF3;CREBZF |
| interleukin-12 alpha subunit binding | IL12BA;IL12B |
| interleukin-12 receptor binding | IL12B;IL12A;JAK2;IL12BA |
| contributes_to interleukin-12 receptor binding | IL23R;IL12RB1;IL12B |
| contributes_to interleukin-23 receptor binding | Il23a; Il12b;IL12B;IL23 |
| protein binding | LCA5;PATL1;CHTOP;MAPK8IP3;MAPRE2;MDH1;LGALS8;VPS35;PYROXD1 |
| protein heterodimerization activity | CLCF1;PPP3CB;CHRNA3;VEGFB;HIST1H2BL;MID2;Bcl2a1b;SCGB2A1;TAF9B |
| protein homodimerization activity | NADKD1;APOA2;RAG1;MAP3K12;GLIPR2;PVRL4;NDP;C6orf108;S100A10 |
IL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12B.
IL23A; IL12A; Il23a; IL12RB1; IL12RB1
- Q&As
- Reviews
Q&As (10)
Ask a questionChIP-seq identifies regulatory elements controlling IL12B gene expression.
Reporter assays monitor IL12B promoter activity under varying conditions.
Primary cell stimulation assays gauge IL12B response to pathogens.
siRNA knockdown uncovers IL12B's role in immune cell activation pathways.
Recombinant protein expression enables functional IL12B studies in vitro.
Co-IP validates IL12B's binding to specific signaling partners.
Genetic variant analysis reveals impacts on IL12B protein function.
Flow cytometry profiles IL12B expression across diverse immune cell types.
Cytokine secretion assays measure IL12B's response kinetics to stimuli.
Co-IP and immunoprecipitation assess IL12B's interactions with other proteins.
Customer Reviews (3)
Write a reviewGood for cytokine assays. -
Effective in Th2 cell differentiation. -
High yield in expression. -
Ask a Question for All IL12B Products
Required fields are marked with *
My Review for All IL12B Products
Required fields are marked with *