IL12B Protein


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Official Full Name interleukin 12B
Background This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Synonyms 40 kD Subunit; CLMF 2; CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 2; Cytotoxic lymphocyte maturation factor 2 p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; HGNC:5970; IL 12 subunit p40; IL 12B; IL-12 subunit p40; IL-12B; IL12 subunit p40; IL12B; IL12B_HUMAN; Interleukin 12 p40; Interleukin 12 subunit beta; Interleukin 12B; Interleukin-12 subunit beta; Interleukin12B; NK cell stimulatory factor chain 2; NKSF; NKSF2; p40; IL12 p40-Carboxyterminal end
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Feline
    • Horse
    • Human
    • Marmoset
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Sheep
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Nicotiana Benthamiana
    • Rat
    • Sf21 Insect Cell
    • Spodoptera Frugiperda
    • Yeast
    • Tag :
    • DDK
    • Fc
    • GST
    • His
    • T7
    • human
    • IgG1
    • Myc/DDK
    • N/A
    • N-His
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Canine IL12B-03C Recombinant Canine IL12B protein, His-tagged Mammalian cells His
    Human IL12A & IL12B-357H Recombinant Human IL12A & IL12B protein HEK293 N/A
    Human IL12B-141H Recombinant Human IL12B, His-tagged Nicotiana Benthamiana His
    Human IL12B-145H Recombinant Human IL12B, His tagged Human Cell His
    Human IL12B-172H Recombinant Human IL12B protein, His-tagged HEK293 His
    Human IL12B-177H Recombinant Human Interleukin 12B E.coli N/A
    Human IL12B-179H Recombinant Human IL12B Protein, DDK-tagged Insect Cell DDK
    Human IL12B-220H Recombinant Human IL12B Sf21 Insect Cell N/A
    Human IL12B-272H Recombinant Human IL12B, StrepII-tagged Human Cell Strep II
    Human IL12B-29638TH Recombinant Human IL12B, His-tagged E.coli His
    Human IL12B-310H Recombinant Human IL12B protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL12B-35H Recombinant Human Interleukin 12B, Fc-Tagged E.coli Fc
    Human IL12B-43H Recombinant Human IL12B, His-tagged E.coli His
    Human IL12B-670H Recombinant Human Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) CHO N/A
    Human Il12b-750H Recombinant Human Il12b Protein, Fc Chimera Mammalian cells Fc
    Mouse Il12b-178M Recombinant Murine Interleukin 12b E.coli N/A
    Mouse Il12b-348M Recombinant Mouse Il12b, Fc-tagged CHO Fc
    Mouse IL12B-435M Recombinant Mouse Il12b, LEVLFQ tagged Human Cell His
    Mouse Il12b-5647M Recombinant Mouse Interleukin 12b, His-tagged Mammalian cells His
    Mouse Il12b-643M Recombinant Mouse Interleukin 12b Spodoptera Frugiperda N/A
    Mouse Il12b-644M Recombinant Mouse Interleukin 12b Spodoptera Frugiperda N/A
    Mouse Il12b-738M Recombinant Mouse Il12b, Fc tagged Human Cell Fc
    Mouse Il12b-847M Recombinant Mouse Il12b protein, His & T7-tagged E.coli His/T7
    Mouse Il12b-8693M Recombinant Mouse Il12b, His tagged Human Cell His
    Mouse IL23A-159M Recombinant Mouse Il23a & Il12b, His tagged Human Cell His
    Rat Il12b&Il12a-748R Recombinant Rat Il12b&Il12a Sf21 Insect Cell N/A
    Rat Il12b&Il23a-747R Recombinant Rat Il12b&Il23a Sf21 Insect Cell N/A
    Rat Il12b-1104R Recombinant Rat Il12b Protein, Fc-tagged HEK293 Fc
    Rat Il12b-849R Recombinant Rat Il12b protein, His & T7-tagged E.coli His/T7
    Rat Il12b-86R Recombinant Rat Interleukin 12b Insect Cell N/A
    Rat Il12b-8789R Recombinant Rat Il12b, His tagged Human Cell His
    Rat Il23a&Il12b-556R Recombinant Rat Il23a&Il12b Human Cell N/A
    Cynomolgus Monkey IL12B-614C Recombinant Cynomolgus IL12B Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL12B-2230R Recombinant Rhesus monkey IL12B Protein, His-tagged Mammalian Cell His
    Dog IL12B-845D Recombinant Dog IL12B protein, His & T7-tagged E.coli His/T7
    Bovine IL12B-233B Recombinant Bovine Interleukin 12B Yeast N/A
    Rabbit IL12B-1028R Recombinant Rabbit IL12B Protein, His-tagged HEK293 His
    Chicken IL12B-7124C Recombinant Chicken IL12B Mammalian Cell His
    Feline IL12B&IL12A-903F Recombinant Feline IL12B&IL12A Sf21 Insect Cell N/A
    Equine IL12B-100E Recombinant Equine IL-12 p40 Yeast N/A
    Marmoset IL12B-154M Recombinant Marmoset IL12B, Fc tagged Human Cell His
    Cattle IL12B-844C Recombinant Cattle IL12B protein, His & T7-tagged E.coli His/T7
    Horse IL12B-846H Recombinant Horse IL12B protein, His & T7-tagged E.coli His/T7
    Pig IL12B-848P Recombinant Pig IL12B protein, His & GST-tagged E.coli His/GST
    Pig IL12B-84S Recombinant Swine IL-12 p40 Yeast N/A
    Feline IL12B-902F Recombinant Feline IL12B Protein, His-tagged Mammalian cells His
    Marmoset IL23A-162M Recombinant Marmoset IL23A & IL12B, His tagged Human Cell Fc
    Human IL12A & IL12B-1908HCL Recombinant Human IL12A & IL12B cell lysate Human Cell N/A
    Human IL12B-2731HCL Recombinant Human IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1779MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1780MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1781MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1782MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12B-1101MCL Recombinant Mouse IL12B cell lysate Human Cell N/A
    Rat IL12B-1197RCL Recombinant Rat IL12B cell lysate Human Cell N/A
    Cynomolgus Monkey IL12A & IL12B-001CCL Recombinant Cynomolgus IL12A & IL12B cell lysate Human Cell N/A
    Marmoset IL12B-1000MCL Recombinant Marmoset IL12B cell lysate Human Cell N/A
    Chicken IL12B-1001C Recombinant Chicken IL12B Protein, His-tagged E.coli N-His
    Human IL12B-2290H Recombinant Human IL12B Protein, His-tagged E.coli N-His
    Human IL12B-3091H Recombinant Human IL12B protein, GST-tagged E.coli GST
    Sheep IL12B-5437S Recombinant Sheep IL12B protein, His-tagged Yeast His
    Human CAB-T9002H Recombinant Anti-Human IL 12B Monoclonal Antibody N/A
    Human DMABT-H19271 Rat Anti-IL12B Monoclonal Antibody Rat N/A
    Human IL12B-128HG GMP Recombinant Human IL12B Protein Insect Cell N/A
    Human IL12B-131HG GMP Recombinant Human IL12B protein, His-tagged HEK293 His
    Human IL12B-1441H Recombinant Human IL12B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Il12b-1235M Recombinant Mouse Il12b Protein Insect Cell
    Mouse Il12b-1236M Recombinant Mouse Il12b Protein Insect Cell
    Mouse Il12b-1237M Recombinant Mouse Il12b Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Sheep IL12B-4330S Recombinant Sheep IL12B Protein Yeast N/A
    Sheep IL12B-576S Recombinant Sheep IL12B Protein (23-327 aa), His-tagged E.coli His

    IL12B involved in several pathways and played different roles in them. We selected most pathways IL12B participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL21B; GM2002; Ccl21a; CXCL16; MET; IL6R; TNFRSF1B; EPOR; TSLP; IL13
    Toll-like receptor signaling pathway CCL4L1; STAT1; PIK3CG; IFNA17; STAT1B; TLR2-2; IKBKG; TLR8; CCL4L2; CD40
    RIG-I-like receptor signaling pathway IL12BA; IFNA7; RNF207B; DDX58; NLRX1; MAP3K1; Ifna11; CXCL8B.3; TRAF2; Ifna15
    Jak-STAT signaling pathway PTPN2; STAT5B; IL12A; IFNK; IL22RA2; AOX2P; Il23a; Il12b; GRB2A; IL28A; SOCS7
    Type I diabetes mellitus CD80; PRF1; HLA-DOA; IFNG; HLA-DRB1; GAD1; IL1A; Fasl; FAS; PTPRN2
    Pertussis ITGAM; MAPK1; GNAI1; C1QC; MAPK3; C1R; MYD88; Il23a; Il12b; IL6; Hc
    Legionellosis RAB1B; TLR4; HSF1; CD14; BCL2L13; ITGB2L; NAIP6; NFKBIA; NFKB2; HSPA1L
    Leishmaniasis NCF1; HLA-DRB4; FCGR3A; HLA-DPA1; MAPK1; NCF2; IFNG; HLA-DRB3; HLA-DQA2; TAB2
    Chagas disease (American trypanosomiasis) IRAK1; MAPK10; TLR9; PIK3R2; PIK3CB; AKT2; IL12A; BDKRB2; MYD88; NFKBIA
    African trypanosomiasis IL1B2; FASLG; THOP1; HBA-A2; TNF; IL6; APOA1; APOL1; HBB-B2; IFNG
    Toxoplasmosis MYD88; LAMA1; BCL2L1; IL10RB; HLA-DMA; HSPA1A; GNAI1; HLA-DOA; MAP2K6; STAT1
    Amoebiasis GNA14; IL12B; Itgam&Itgb2; ACTN1; COL3A1; ITGAM; MUC2; GNA11; IFNG; CXCL1
    Tuberculosis MAPK9; IL18; NFKB1; CAMK2B; ATP6V0C; BAX; IFNA13; PIK3C3; IRAK4; IFNA21
    Herpes simplex infection HMGN1; LTA; H2-AB1; TAP2; EIF2AK3; EEF1DB; HNRNPK; TP53; SRSF7A; DAXX
    Proteoglycans in cancer SDC4; HIF1A; TLR2; WNT7B; PIK3R2; CAV3; NRAS; MAPK11; ITGA5; PRKACB
    Inflammatory bowel disease (IBD) IL1B; RORA; IL12A; IL13; HLA-DPA1; IL23; TBX21; MAF; IL12RB2; NFATC1
    Allograft rejection MICA; HLA-DRB4; FASLG; PRF1; IL12A; HLA-E; CD28; CD40; HLA-G; H2-AA

    IL12B has several biochemical functions, for example, contributes_to cytokine activity, cytokine receptor activity, contributes_to growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12B itself. We selected most functions IL12B had, and list some proteins which have the same functions with IL12B. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to cytokine activity IL12A; CLCF1; CRLF1; IL12B
    cytokine receptor activity IL13RA1; IL12B; IL17RB; CRFB6; CRFB16; PRLRA; IL21R.2; IL20RB; IRX1; IL15RA
    contributes_to growth factor activity IL12B; IL12A
    identical protein binding ITGA2B; CRYAB; TP73; MRAP2; GRB7; NUFIP1; TTC32; MICU1; PARP1; HAPLN2
    interleukin-12 alpha subunit binding IL12B; IL12BA
    interleukin-12 receptor binding IL12A; JAK2; IL12BA; IL12B
    contributes_to interleukin-12 receptor binding IL23R; IL12RB1; IL12B
    contributes_to interleukin-23 receptor binding IL12B; IL23; Il23a; Il12b
    protein binding CLU; ARL6IP5; NUBP2; GTPBP4; WDR77; PELP1; PSMA5; MAPK4; NSMCE2; MNDA
    protein heterodimerization activity ATF3; KCNB1; MYOG; HIST1H4I; PVALB; TAF11; ANO2; ADD2; CEBPA; SDCBP
    protein homodimerization activity MYOM3; NR4A3; UGT1A6B; C6orf108; HM13; CDA; NR4A2; APOA1BP; PRKG2; SNX6

    IL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12B.

    IL23A; IL12A; Il23a; IL12RB1; IL12RB1

    Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
    Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).


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