IL12B

  • Official Full Name

    interleukin 12B

  • Background

    This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
  • Synonyms

    40 kD Subunit; CLMF 2; CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 2; Cytotoxic lymphocyte maturation factor 2 p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; HGNC:5970; IL 12 subunit p40; IL 12B; IL-12 subunit p40; IL-12B; IL12 subunit p40; IL12B; IL12B_HUMAN; Interleukin 12 p40; Interleukin 12 subunit beta; Interleukin 12B; Interleukin-12 subunit beta; Interleukin12B; NK cell stimulatory factor chain 2; NKSF; NKSF2; p40; IL12 p40-Carboxyterminal end;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Cell & Tissue Lysates
    • Antibody
    • Recombinant Antibodies
    • GMP Proteins
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Feline
    • Horse
    • Human
    • Marmoset
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Sheep
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Rat
    • Sf21 Insect Cell
    • Spodoptera Frugiperda
    • Yeast
    • Tag :
    • DDK
    • Fc
    • GST
    • His
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|GST
    • His|T7
    • human|IgG1|Fc
    • Myc
    • MYC
    • N/A
    • N
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bovine IL12B-233B Recombinant Bovine Interleukin 12B Yeast N/A
    Canine IL12B-3C-B Recombinant Canine IL12B Protein Pre-coupled Magnetic Beads HEK293
    Canine IL12B-03C Active Recombinant Canine IL12B protein, His-tagged Mammalian cells His
    Canine IL12B-3C Recombinant Canine IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cattle IL12B-844C Recombinant Cattle IL12B protein, His & T7-tagged E.coli His/T7
    Chicken IL12B-7124C Recombinant Chicken IL12B Mammalian Cell His
    Chicken IL12B-1001C Recombinant Chicken IL12B Protein, His-tagged E.coli N-His
    Cynomolgus Monkey IL12B-361C-B Recombinant Cynomolgus Monkey IL12B Protein Pre-coupled Magnetic Beads HEK293
    Cynomolgus Monkey IL12B-361C Recombinant Cynomolgus Monkey IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cynomolgus Monkey IL12B-614C Recombinant Cynomolgus IL12B Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey IL12A & IL12B-001CCL Recombinant Cynomolgus IL12A & IL12B cell lysate Human Cell N/A
    Dog IL12B-845D Recombinant Dog IL12B protein, His & T7-tagged E.coli His/T7
    Equine IL12B-100E Recombinant Equine IL-12 p40 Yeast N/A
    Feline IL12B-5F-B Recombinant Feline IL12B Protein Pre-coupled Magnetic Beads HEK293
    Feline IL12B&IL12A-903F Active Recombinant Feline IL12B&IL12A Sf21 Insect Cell N/A
    Feline IL12B-902F Active Recombinant Feline IL12B Protein, His-tagged Mammalian cells His
    Feline IL12B-5F Recombinant Feline IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Horse IL12B-846H Recombinant Horse IL12B protein, His & T7-tagged E.coli His/T7
    Human IL12B-220H Recombinant Human IL12B Sf21 Insect Cell N/A
    Human Il12b-750H Active Recombinant Human Il12b Protein, Fc Chimera Mammalian cells Fc
    Human IL12B-503H Recombinant Human IL12B Protein, Fc-tagged Fc
    Human IL12A & IL12B-357H Recombinant Human IL12A & IL12B protein HEK293 N/A
    Human IL12B-2731HCL Recombinant Human IL12B cell lysate Human Cell N/A
    Human IL12B-502H Recombinant Human IL12B Protein
    Human IL12B-1164H-B Recombinant Human IL12B Protein Pre-coupled Magnetic Beads HEK293
    Human IL12B-1441H Recombinant Human IL12B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL12B-177H Recombinant Human Interleukin 12B E.coli N/A
    Human DMABT-H19271 Rat Anti-IL12B Monoclonal Antibody Rat N/A
    Human CAB-T9002H Recombinant Anti-Human IL 12B Monoclonal Antibody N/A
    Human IL12B-2290H Recombinant Human IL12B Protein, His-tagged E.coli N-His
    Human IL12B-3091H Recombinant Human IL12B protein, GST-tagged E.coli GST
    Human IL12B-29638TH Recombinant Human IL12B, His-tagged E.coli His
    Human IL12B-131HG GMP Recombinant Human IL12B protein HEK293
    Human IL12B-310H Recombinant Human IL12B protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL12B-77H Recombinant Human IL12B Protein Human Cell
    Human IL12B-43H Recombinant Human IL12B, His-tagged E.coli His
    Human IL12B-181I Recombinant Human IL12B Protein HEK293
    Human IL12B-272H Recombinant Human IL12B, StrepII-tagged Human Cell Strep II
    Human IL12A & IL12B-1908HCL Recombinant Human IL12A & IL12B cell lysate Human Cell N/A
    Human IL12B-141H Active Recombinant Active Human IL12B Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL12B-145H Recombinant Human IL12B, His tagged Human Cell His
    Human IL12B-1608H Recombinant Human IL12B protein, Fc-tagged HEK293 Fc
    Human IL12B-670H Recombinant Human Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) CHO N/A
    Human IL12B-172H Recombinant Human IL12B protein, His-tagged HEK293 His
    Human IL12B-35H Recombinant Human Interleukin 12B, Fc-Tagged E.coli Fc
    Human IL12B-1164H Recombinant Human IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL12B-128HG GMP Recombinant Human IL12B Protein Insect Cell N/A
    Human IL12B-322H Recombinant Human IL12B Protein, Fc-tagged HEK293 Fc
    Human IL12B-179H Recombinant Human IL12B Protein, DDK-tagged Insect Cell DDK
    Marmoset IL23A-162M Recombinant Marmoset IL23A & IL12B, His tagged Human Cell Fc
    Marmoset IL12B-154M Recombinant Marmoset IL12B, Fc tagged Human Cell His
    Marmoset IL12B-1000MCL Recombinant Marmoset IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1782MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse Il12b-348M Recombinant Mouse Il12b, Fc-tagged CHO Fc
    Mouse IL12A & IL12B-1779MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1780MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12B-1101MCL Recombinant Mouse IL12B cell lysate Human Cell N/A
    Mouse Il12b-8693M Recombinant Mouse Il12b protein, His-tagged HEK293 His
    Mouse IL12A & IL12B-1781MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse Il12b-738M Recombinant Mouse Il12b, Fc tagged Human Cell Fc
    Mouse Il12b-01M Active Recombinant Mouse Il12b Protein, His-Tagged E.coli His
    Mouse IL12B-435M Recombinant Mouse Il12b, LEVLFQ tagged Human Cell His
    Mouse Il12b-644M Active Recombinant Mouse Interleukin 12b Spodoptera Frugiperda N/A
    Mouse IL23A-159M Recombinant Mouse Il23a & Il12b, His tagged Human Cell His
    Mouse Il12b-142M Recombinant Active Mouse IL12B Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il12b-178M Recombinant Murine Interleukin 12b E.coli N/A
    Mouse IL12B-82M Recombinant Mouse IL12B Protein Human Cell
    Mouse Il12b-643M Active Recombinant Mouse Interleukin 12b Spodoptera Frugiperda N/A
    Mouse Il12b-257I Recombinant Mouse Il12b Protein CHO
    Mouse IL12B-1607M Recombinant Mouse IL12B protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Mouse Il12b-4492M-B Recombinant Mouse Il12b Protein Pre-coupled Magnetic Beads HEK293
    Mouse Il12b-5647M Active Recombinant Mouse Interleukin 12b, His-tagged Mammalian cells His
    Mouse Il12b-1235M Recombinant Mouse Il12b Protein Insect Cell
    Mouse Il12b-847M Recombinant Mouse Il12b protein, His & T7-tagged E.coli His/T7
    Mouse Il12b-1236M Recombinant Mouse Il12b Protein Insect Cell
    Mouse Il12b-4492M Recombinant Mouse Il12b Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il12b-1237M Recombinant Mouse Il12b Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse IL12B-0308M Recombinant Mouse IL12B protein HEK293 N/A
    Pig IL12B-84S Recombinant Swine IL-12 p40 Yeast N/A
    Pig IL12B-848P Recombinant Pig IL12B protein, His & GST-tagged E.coli His/GST
    Rabbit IL12B-1028R Recombinant Rabbit IL12B protein, His-tagged HEK293 His
    Rat Il12b-1104R Recombinant Rat Il12b Protein, Fc-tagged HEK293 Fc
    Rat Il23a&Il12b-556R Recombinant Rat Il23a&Il12b Human Cell N/A
    Rat Il12b&Il23a-747R Active Recombinant Rat Il12b&Il23a Sf21 Insect Cell N/A
    Rat Il12b-849R Recombinant Rat Il12b protein, His & T7-tagged E.coli His/T7
    Rat Il12b-86R Recombinant Rat Interleukin 12b Insect Cell N/A
    Rat Il12b&Il12a-748R Active Recombinant Rat Il12b&Il12a Sf21 Insect Cell N/A
    Rat IL12B-1197RCL Recombinant Rat IL12B cell lysate Human Cell N/A
    Rat Il12b-8789R Recombinant Rat Il12b, His tagged Human Cell His
    Rhesus Macaque IL12B-2051R Recombinant Rhesus Macaque IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque IL12B-2051R-B Recombinant Rhesus Macaque IL12B Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque IL12B-2230R Recombinant Rhesus monkey IL12B Protein, His-tagged Mammalian Cell His
    Sheep IL12B-4330S Recombinant Sheep IL12B Protein Yeast N/A
    Sheep IL12B-576S Recombinant Sheep IL12B Protein (23-327 aa), His-tagged E.coli His
    Sheep IL12B-5437S Recombinant Sheep IL12B protein, His-tagged Yeast His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL12B Related Articles
    • IL12B Related Gene Family
    • IL12B Related Research Area
    • IL12B Related Signal Pathway

    IL12B involved in several pathways and played different roles in them. We selected most pathways IL12B participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionCSF1RA;CCL4L2;IFNA17;TNFRSF10B;LOC100033925;THPO;Ifnlr1;PDGFRB;CCL4
    Toll-like receptor signaling pathwayIfna11;IFNPHI3;MAP2K4A;IFNA1;IFNA2;CXCL8B.3;SPP1;MAPK3;MAPK1
    RIG-I-like receptor signaling pathwayOTUD5A;IL12B;IFNA2;MAPK14A;TRAF6;IFNA17;MAPK8;MAPK13;MAPK12A
    Jak-STAT signaling pathwayCRFB4;IL2RB;Ifna11;IL10RB;CSH1;IL15RA;STAT3;IL27RA;IFNA16
    Type I diabetes mellitusCPE;GZMB;HLA-A;CD80;H2-AA;INS1;HLA-DMA;HLA-DOB;HLA-DPA1
    PertussisIL-8;IRAK1;TLR4;IL12A;MYD88;MAPK3;Hc;CXCL5;NLRP3
    LegionellosisCASP1;HSPA8;ITGB2;IL18;NAIP1;CR1;EEF1A1;CASP9;BNIP3
    LeishmaniasisNOS2;FCGR3A;NFKB1;FCGR1A;HLA-DPA1;TAB2;MARCKSL1;IFNGR2;IFNGR1
    Chagas disease (American trypanosomiasis)CCL2;GNAS;CCL3L3;GNAI2;GNA11;C1QC;GNAI1;NOS2;PLCB3
    African trypanosomiasisVCAM1;HBA-A2;LAMA4;HBB-B1;THOP1;PRKCB;PRKCA;GNAQ;IDO1
    ToxoplasmosisLAMA2;PIK3R3;LAMA4;Toxoplasma Gondii Profilin Family Protein;LAMA1;HLA-DOA;HLA-DMA;H2-AB1;HLA-DRB1
    AmoebiasisIL1B;PIK3R1;RAB7;COL2A1;PRKACG;GM-CSF;PIK3R2;SERPINB13;CD1d1
    TuberculosisATP6V0A1;IL23;ATP6V0A2;LAMP1;HLA-DRB3;TRAF6;IRAK4;STAT1;CAMK2A
    MeaslesIFNAR2;IFNA4;STAT3;IFNG;CD209A;PIK3CB;CD3G;IL6;IFNA2
    Influenza ATMPRSS4;TNFSF10;HNRNPUL1;BCL2L2-PABPN1;PRSS3;TNF;IVNS1ABP;HLA-DQA2;FASLG
    Herpes simplex infectionIRF7;SRSF2B;MAP3K7;RELA;BLB1;HLA-DQA2;IFNA13;CFP;HLA-DRB3
    Proteoglycans in cancerPRKACG;WNT2B;HCLS1;PPP1R12B;WNT6;TFAP4;CCND1;CDC42;NUDT16L1
    Inflammatory bowel disease (IBD)Il23a;FOXP3;RELA;IL4R;IFNG;HLA-DPA1;IL12B;TGFB1;HLA-DRB5
    Allograft rejectionIL10;HLA-F;H2-Q10;IL5;HLA-DQA1;IFNG;IL12A;HLA-DMB;HLA-DRA

    IL12B has several biochemical functions, for example, contributes_to cytokine activity, cytokine receptor activity, contributes_to growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12B itself. We selected most functions IL12B had, and list some proteins which have the same functions with IL12B. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to cytokine activityCRLF1;IL12A;CLCF1;IL12B
    cytokine receptor activityGHR;Ifnlr1;IL11RA;CRFB16;IL20RB;LIFRA;CRFB12;IL4R.1;IL13RA1
    contributes_to growth factor activityIL12B;IL12A
    identical protein bindingCLDN17;PAFAH1B3;SNCA;GCC2;CBLL1;PPP5C;HAPLN2;IRF3;CREBZF
    interleukin-12 alpha subunit bindingIL12BA;IL12B
    interleukin-12 receptor bindingIL12B;IL12A;JAK2;IL12BA
    contributes_to interleukin-12 receptor bindingIL23R;IL12RB1;IL12B
    contributes_to interleukin-23 receptor bindingIl23a; Il12b;IL12B;IL23
    protein bindingLCA5;PATL1;CHTOP;MAPK8IP3;MAPRE2;MDH1;LGALS8;VPS35;PYROXD1
    protein heterodimerization activityCLCF1;PPP3CB;CHRNA3;VEGFB;HIST1H2BL;MID2;Bcl2a1b;SCGB2A1;TAF9B
    protein homodimerization activityNADKD1;APOA2;RAG1;MAP3K12;GLIPR2;PVRL4;NDP;C6orf108;S100A10

    IL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12B.

    IL23A; IL12A; Il23a; IL12RB1; IL12RB1

    Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
    Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).
    IL
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    Could you explain the use of ChIP-seq in studying IL12B transcriptional regulation? 05/12/2021

    ChIP-seq identifies regulatory elements controlling IL12B gene expression.

    Can you elaborate on the use of reporter assays to monitor IL12B promoter activity? 05/02/2021

    Reporter assays monitor IL12B promoter activity under varying conditions.

    What methods evaluate IL12B's response to different pathogenic stimuli in primary cells? 10/30/2020

    Primary cell stimulation assays gauge IL12B response to pathogens.

    How does siRNA knockdown of IL12B elucidate its role in immune cell activation? 05/25/2020

    siRNA knockdown uncovers IL12B's role in immune cell activation pathways.

    How does recombinant protein expression and purification aid in IL12B functional studies? 04/30/2020

    Recombinant protein expression enables functional IL12B studies in vitro.

    How does co-immunoprecipitation validate IL12B's association with signaling partners? 04/12/2018

    Co-IP validates IL12B's binding to specific signaling partners.

    What techniques are employed to analyze the impact of IL12B genetic variants on protein function? 12/03/2017

    Genetic variant analysis reveals impacts on IL12B protein function.

    How does flow cytometry reveal IL12B's expression dynamics in different immune cell subsets? 10/31/2017

    Flow cytometry profiles IL12B expression across diverse immune cell types.

    What experimental approaches determine IL12B's cytokine secretion kinetics upon stimulation? 09/29/2017

    Cytokine secretion assays measure IL12B's response kinetics to stimuli.

    What are the methods to assess IL12B's protein-protein interactions in a cellular context? 08/22/2017

    Co-IP and immunoprecipitation assess IL12B's interactions with other proteins.

    Customer Reviews (3)

    Write a review
    Reviews
    04/08/2020

      Good for cytokine assays. -

      01/06/2020

        Effective in Th2 cell differentiation. -

        01/12/2019

          High yield in expression. -

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