IL12B Protein

IL12B

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IL12B

Official Full Name interleukin 12B
Background This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Synonyms 40 kD Subunit; CLMF 2; CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 2; Cytotoxic lymphocyte maturation factor 2 p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; HGNC:5970; IL 12 subunit p40; IL 12B; IL-12 subunit p40; IL-12B; IL12 subunit p40; IL12B; IL12B_HUMAN; Interleukin 12 p40; Interleukin 12 subunit beta; Interleukin 12B; Interleukin-12 subunit beta; Interleukin12B; NK cell stimulatory factor chain 2; NKSF; NKSF2; p40; IL12 p40-Carboxyterminal end
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Feline
    • Horse
    • Human
    • Marmoset
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Sheep
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Rat
    • Sf21 Insect Cell
    • Spodoptera Frugiperda
    • Yeast
    • Tag :
    • DDK
    • Fc
    • Flag
    • GST
    • His
    • His(C-ter)
    • T7
    • human
    • IgG1
    • Myc/DDK
    • N/A
    • N-His
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Canine IL12B-03C Active Recombinant Canine IL12B protein, His-tagged Mammalian cells His Inquiry
    Human IL12B-141H Active Recombinant Active Human IL12B Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human Il12b-750H Active Recombinant Human Il12b Protein, Fc Chimera Mammalian cells Fc Inquiry
    Mouse Il12b-5647M Active Recombinant Mouse Interleukin 12b, His-tagged Mammalian cells His Inquiry
    Mouse Il12b-643M Active Recombinant Mouse Interleukin 12b Spodoptera Frugiperda N/A Inquiry
    Mouse Il12b-644M Active Recombinant Mouse Interleukin 12b Spodoptera Frugiperda N/A Inquiry
    Rat Il12b&Il12a-748R Active Recombinant Rat Il12b&Il12a Sf21 Insect Cell N/A Inquiry
    Rat Il12b&Il23a-747R Active Recombinant Rat Il12b&Il23a Sf21 Insect Cell N/A Inquiry
    Feline IL12B&IL12A-903F Active Recombinant Feline IL12B&IL12A Sf21 Insect Cell N/A Inquiry
    Feline IL12B-902F Active Recombinant Feline IL12B Protein, His-tagged Mammalian cells His Inquiry
    Mouse Il12b-01M Active Recombinant Mouse Il12b Protein, His-Tagged E.coli His Inquiry
    Human IL12A & IL12B-357H Recombinant Human IL12A & IL12B protein HEK293 N/A Inquiry
    Human IL12B-145H Recombinant Human IL12B, His tagged Human Cell His Inquiry
    Human IL12B-172H Recombinant Human IL12B protein, His-tagged HEK293 His Inquiry
    Human IL12B-177H Recombinant Human Interleukin 12B E.coli N/A Inquiry
    Human IL12B-179H Recombinant Human IL12B Protein, DDK-tagged Insect Cell DDK Inquiry
    Human IL12B-220H Recombinant Human IL12B Sf21 Insect Cell N/A Inquiry
    Human IL12B-272H Recombinant Human IL12B, StrepII-tagged Human Cell Strep II Inquiry
    Human IL12B-29638TH Recombinant Human IL12B, His-tagged E.coli His Inquiry
    Human IL12B-310H Recombinant Human IL12B protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Human IL12B-35H Recombinant Human Interleukin 12B, Fc-Tagged E.coli Fc Inquiry
    Human IL12B-43H Recombinant Human IL12B, His-tagged E.coli His Inquiry
    Human IL12B-670H Recombinant Human Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) CHO N/A Inquiry
    Mouse Il12b-178M Recombinant Murine Interleukin 12b E.coli N/A Inquiry
    Mouse Il12b-348M Recombinant Mouse Il12b, Fc-tagged CHO Fc Inquiry
    Mouse IL12B-435M Recombinant Mouse Il12b, LEVLFQ tagged Human Cell His Inquiry
    Mouse Il12b-738M Recombinant Mouse Il12b, Fc tagged Human Cell Fc Inquiry
    Mouse Il12b-847M Recombinant Mouse Il12b protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse Il12b-8693M Recombinant Mouse Il12b, His tagged Human Cell His Inquiry
    Mouse IL23A-159M Recombinant Mouse Il23a & Il12b, His tagged Human Cell His Inquiry
    Rat Il12b-1104R Recombinant Rat Il12b Protein, Fc-tagged HEK293 Fc Inquiry
    Rat Il12b-849R Recombinant Rat Il12b protein, His & T7-tagged E.coli His/T7 Inquiry
    Rat Il12b-86R Recombinant Rat Interleukin 12b Insect Cell N/A Inquiry
    Rat Il12b-8789R Recombinant Rat Il12b, His tagged Human Cell His Inquiry
    Rat Il23a&Il12b-556R Recombinant Rat Il23a&Il12b Human Cell N/A Inquiry
    Cynomolgus Monkey IL12B-614C Recombinant Cynomolgus IL12B Protein, His-tagged Mammalian Cell His Inquiry
    Rhesus Macaque IL12B-2230R Recombinant Rhesus monkey IL12B Protein, His-tagged Mammalian Cell His Inquiry
    Dog IL12B-845D Recombinant Dog IL12B protein, His & T7-tagged E.coli His/T7 Inquiry
    Bovine IL12B-233B Recombinant Bovine Interleukin 12B Yeast N/A Inquiry
    Rabbit IL12B-1028R Recombinant Rabbit IL12B Protein, His-tagged HEK293 His Inquiry
    Chicken IL12B-7124C Recombinant Chicken IL12B Mammalian Cell His Inquiry
    Equine IL12B-100E Recombinant Equine IL-12 p40 Yeast N/A Inquiry
    Marmoset IL12B-154M Recombinant Marmoset IL12B, Fc tagged Human Cell His Inquiry
    Cattle IL12B-844C Recombinant Cattle IL12B protein, His & T7-tagged E.coli His/T7 Inquiry
    Horse IL12B-846H Recombinant Horse IL12B protein, His & T7-tagged E.coli His/T7 Inquiry
    Pig IL12B-848P Recombinant Pig IL12B protein, His & GST-tagged E.coli His/GST Inquiry
    Pig IL12B-84S Recombinant Swine IL-12 p40 Yeast N/A Inquiry
    Marmoset IL23A-162M Recombinant Marmoset IL23A & IL12B, His tagged Human Cell Fc Inquiry
    Human IL12A & IL12B-1908HCL Recombinant Human IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Human IL12B-2731HCL Recombinant Human IL12B cell lysate Human Cell N/A Inquiry
    Mouse IL12A & IL12B-1779MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Mouse IL12A & IL12B-1780MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Mouse IL12A & IL12B-1781MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Mouse IL12A & IL12B-1782MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Mouse IL12B-1101MCL Recombinant Mouse IL12B cell lysate Human Cell N/A Inquiry
    Rat IL12B-1197RCL Recombinant Rat IL12B cell lysate Human Cell N/A Inquiry
    Cynomolgus Monkey IL12A & IL12B-001CCL Recombinant Cynomolgus IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Marmoset IL12B-1000MCL Recombinant Marmoset IL12B cell lysate Human Cell N/A Inquiry
    Chicken IL12B-1001C Recombinant Chicken IL12B Protein, His-tagged E.coli N-His Inquiry
    Human IL12B-1267HFL Recombinant Full Length Human IL12B Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Mouse Il12b-142M Recombinant Active Mouse IL12B Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human IL12B-2290H Recombinant Human IL12B Protein, His-tagged E.coli N-His Inquiry
    Human IL12B-3091H Recombinant Human IL12B protein, GST-tagged E.coli GST Inquiry
    Sheep IL12B-5437S Recombinant Sheep IL12B protein, His-tagged Yeast His Inquiry
    Human IL12B-77H Recombinant Human IL12B Protein Human Cell Inquiry
    Mouse IL12B-82M Recombinant Mouse IL12B Protein Human Cell Inquiry
    Human CAB-T9002H Recombinant Anti-Human IL 12B Monoclonal Antibody N/A Inquiry
    Human DMABT-H19271 Rat Anti-IL12B Monoclonal Antibody Rat N/A Inquiry
    Human IL12B-128HG GMP Recombinant Human IL12B Protein Insect Cell N/A Inquiry
    Human IL12B-131HG GMP Recombinant Human IL12B protein, His-tagged HEK293 His Inquiry
    Human IL12B-1441H Recombinant Human IL12B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Il12b-1235M Recombinant Mouse Il12b Protein Insect Cell Inquiry
    Mouse Il12b-1236M Recombinant Mouse Il12b Protein Insect Cell Inquiry
    Mouse Il12b-1237M Recombinant Mouse Il12b Protein, MYC/DDK-tagged HEK293T MYC/DDK Inquiry
    Sheep IL12B-4330S Recombinant Sheep IL12B Protein Yeast N/A Inquiry
    Sheep IL12B-576S Recombinant Sheep IL12B Protein (23-327 aa), His-tagged E.coli His Inquiry

    IL12B involved in several pathways and played different roles in them. We selected most pathways IL12B participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction KITLGB; Ifna15; PDGFA; Ifna11; ACVR2A; TNFRSF12A; IL21; PDGFRA; OSTN; CCR5
    Toll-like receptor signaling pathway CXCL8B.3; IL12A; IL12BA; IFNA13; FADD; NFKBIAA; MAP2K1; TLR7; IFNA3; TLR4BA
    RIG-I-like receptor signaling pathway MAPK8B; IFNE; PL10; MAPK12A; IFNA16; MAPK11; IFNA1; CASP10; IL8L1; IFNA6
    Jak-STAT signaling pathway PIAS2; SOCS5B; IL4; IFNB; IL6R; GM13305; OSM; IFNA4; LIFRA; PIK3R3B
    Type I diabetes mellitus Il2; HLA-DQA1; PRF1; HLA-DRA; HLA-E; HLA-A; HLA-DOB; TNF; GAD1; H2-AB1
    Pertussis IL12A; IRF1; NFKB1; C1RA; IRAK4; LY96; CALM2; CXCL5; Itgam&Itgb2; GNAI1
    Legionellosis EEF1A1; IL6; HSPD1; TLR2; NFKBIA; RELA; CD14; HSPA1A; CR1; RAB1B
    Leishmaniasis TLR2; HLA-DQA1; ITGA4; TGFB3; FCGR1; IFNGR2; TAB2; HLA-DMB; IL12B; IL12A
    Chagas disease (American trypanosomiasis) PPP2R2B; IL10; C3; TGFB1; PPP2CA; PPP2R1B; GNAI2; PPP2R2D; GNAI1; MAPK13
    African trypanosomiasis F2RL1; IDO1; VCAM1; APOA1; HBB; LAMA4; PLCB3; PRKCG; FASLG; TNF
    Toxoplasmosis IFNGR1; HLA-DPA1; HLA-DRB3; HSPA1L; LDLR; MYD88; MAPK3; IL10RB; MAP2K3; IL12B
    Amoebiasis AASS; PIK3R5; COL24A1; COL4A3; PIK3CB; COL5A2; ACTN4; IL1B; LAMA3; GNA14
    Tuberculosis HLA-DRB4; IFNA6; HLA-DQA2; IL12A; SPHK2; ITGAM; CD209B; IFNA2; IL1A; ATP6AP1
    Measles IKBKE; PIK3CB; STAT1; IL2RB; CD46; IFNA8; IFNA5; MAVS; PIK3CD; IFNA1
    Influenza A NUP98; TLR7; CASP1; HLA-DQA1; PABPN1; MAVS; RAE1; SOCS3; MYD88; MAPK3
    Herpes simplex infection TNFRSF14; SRPK1B; C3A.2; PTPN11B; CDC34; MAPK8A; LTA; CD74; TRAF6; Hc
    Proteoglycans in cancer WNT3A; WNT11; WNT4; TFAP4; MAP2K1; TP53; RRAS2; CAV2; GRB2; ITGB5
    Inflammatory bowel disease (IBD) FOXP3; TLR2; IL23R; RORA; HLA-DOA; IL5; TBX21; IFNG; HLA-DOB; STAT4
    Allograft rejection H2-Q10; IL4; HLA-E; H2-AB1; CD28; CD40; HLA-DQA1; HLA-DQA2; PRF1; HLA-G

    IL12B has several biochemical functions, for example, contributes_to cytokine activity, cytokine receptor activity, contributes_to growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12B itself. We selected most functions IL12B had, and list some proteins which have the same functions with IL12B. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to cytokine activity CRLF1; IL12B; IL12A; CLCF1
    cytokine receptor activity CSF3R; LIFRB; IL2RGA; CRFB16; GHR; CRFB6; IL28RA; IL13RA2; CRFB4; IRX1
    contributes_to growth factor activity IL12B; IL12A
    identical protein binding BNIPL; TRP63; ORAI1; TRIP13; TPCN2; PDGFB; SDF4; PLIN5; ATG16L1; PNMA5
    interleukin-12 alpha subunit binding IL12BA; IL12B
    interleukin-12 receptor binding JAK2; IL12BA; IL12B; IL12A
    contributes_to interleukin-12 receptor binding IL12RB1; IL12B; IL23R
    contributes_to interleukin-23 receptor binding IL23; IL12B; Il23a; Il12b
    protein binding KCNA3; DUSP12; PLEC; RAB3C; FGFR1OP2; GNL3L; BSX; CCDC22; GLS2; CETN2
    protein heterodimerization activity PRMT5; MLXIPL; TCF3; TPD52; SMAD1; SYT5; ZHX3; HIST1H4I; BMP7A; MCL1
    protein homodimerization activity DMRTB1; B4GALT1; PLD6; STOM; XPNPEP1; DMRTC1C2; XCL1; PITX2; CEBPE; CUBN

    IL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12B.

    IL23A; IL12A; Il23a; IL12RB1; IL12RB1

    Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
    Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).

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