IL12B
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Official Full Name
interleukin 12B -
Overview
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. -
Synonyms
40 kD Subunit;CLMF 2;CLMF;CLMF p40;CLMF2;Cytotoxic lymphocyte maturation factor 2;Cytotoxic lymphocyte maturation factor 2 p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit;HGNC:5970;IL 12 subunit p40;IL 12B;IL-12 subunit p40;IL-12B;IL12 subunit p40;IL12B;IL12B_HUMAN;Interleukin 12 p40;Interleukin 12 subunit beta;Interleukin 12B;Interleukin-12 subunit beta;Interleukin12B;NK cell stimulatory factor chain 2;NKSF;NKSF2;p40;IL12 p40-Carboxyterminal end
Recombinant Proteins
- Human
- Sheep
- Canine
- Mouse
- Feline
- Marmoset
- Equine
- Rabbit
- Rat
- Rhesus macaque
- Bovine
- Cynomolgus
- Chicken
- Cattle
- Dog
- Horse
- Pig
- Ferret
- Hamster
- Goat
- Golden hamster
- HEK293
- Yeast
- Mammalian Cells
- E.coli
- S.frugiperda
- Insect Cells
- Human Cells
- Sf21 Cells
- CHO
- C-His
- Rat
- Baculovirus
- His
- Fc
- Non
- Flag
- T7
- GST
- Avi
- DDK
- Myc
Involved Pathway
IL12B involved in several pathways and played different roles in them. We selected most pathways IL12B participated on our site, such as Cytokine-cytokine receptor interaction,Toll-like receptor signaling pathway,RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Allograft rejection | Il2,H2-AA,FAS,HLA-DMA,CD86,HLA-B,HLA-DMB,CD40,HLA-DRB5,IL4 |
| Toxoplasmosis | TLR2,MAPK8,Toxoplasma Gondii Dense Granule Protein 7,BIRC2,IRAK4,MAPK11,AKT1,GNAI3,NFKB1,PIK3CA |
| Cytokine-cytokine receptor interaction | CCL20A.3,IL2RG,IL13RA1,IL1B,IFNA21,M17,INHBB,CCL1,INHBE,CCL25 |
| Leishmaniasis | FCGR4,ITGB2,HLA-DMA,HLA-DQB1,NFKBIA,MAPK12,NCF4,IL1A,ITGB1,HLA-DPB1 |
| African trypanosomiasis | LAMA4,FAS,FASLG,MYD88,PLCB1,VCAM1,PRKCG,PRKCB,PLCB4,TNF |
| Chagas disease (American trypanosomiasis) | PIK3CA,FOS,PPP2CA,CD3D,PIK3CB,C3,GNAO1,PPP2R2D,ACE,FADD |
| Measles | TBK1,STAT5B,CCNE2,HSPA6,IL4,FAS,STAT1,Ifna11,SLAMF1,PIK3R2 |
| Tuberculosis | H2-AB1,ATP6V0D1,Il23a,HLA-DRB5,IFNGR1,HLA-DPB1,CD209C,TRAF6,TLR4,CALM2 |
| Toll-like receptor signaling pathway | TLR2-1,TLR5B,IFNA2,MAPK3,IFNA1,IFNA6,MAP2K4A,Ifna15,MAP2K1,TMED7-TICAM2 |
Protein Function
IL12B has several biochemical functions, for example, contributes_to cytokine activity,cytokine receptor activity,contributes_to growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12B itself. We selected most functions IL12B had, and list some proteins which have the same functions with IL12B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-12 alpha subunit binding | IL12BA |
| contributes_to interleukin-12 receptor binding | IL12RB1,IL23R |
| interleukin-12 receptor binding | JAK2,IL12A,IL12BA |
| protein binding | BST2,FAM128B,FAAH,KCNE4,CITED2,WWTR1,EDN1,GOPC,PGM2,DDX23 |
| protein homodimerization activity | HES1,MAPK4,SYNE1,FZD1,ODC1,MAP3K9,ABCD1,NR2F2,XPNPEP1,BCL2A1A |
| identical protein binding | COL18A1,PRMT8,IK,MRFAP1L1,IFI16,SH3GLB1,WAS,AGXT2,CLDN1,VIL1 |
| contributes_to interleukin-23 receptor binding | Il23a; Il12b,IL23 |
| contributes_to growth factor activity | IL12A |
| protein heterodimerization activity | P2RY1,DVL3,KCNK3,Bcl2a1b,ADIPOR1,CXCL13,RELA,TXLNG,MAFGB,HIST1H4E |
Interacting Protein
IL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12B.
IL23A;IL12A;Il23a;IL12RB1;IL12RB1
IL12B Related Signal Pathway
Resources
Research Area
Natural Killer Cells (NK Cells) Markersgamma delta T Cells
Natural Killer T (NKT) Cells
Regulatory T Cells (Tregs)
T Cell Cytokine Signaling
Rheumatoid arthritis Therapeutic Targets
IL-12 Family Ligands
Related Services
Related Products
References
- Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
- Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).
