IL12B

  • Official Full Name

    interleukin 12B

  • Overview

    This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
  • Synonyms

    40 kD Subunit; CLMF 2; CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 2; Cytotoxic lymphocyte maturation factor 2 p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; HGNC:5970; IL 12 subunit p40; IL 12B; IL-12 subunit p40; IL-12B; IL12 subunit p40; IL12B; IL12B_HUMAN; Interleukin 12 p40; Interleukin 12 subunit beta; Interleukin 12B; Interleukin-12 subunit beta; Interleukin12B; NK cell stimulatory factor chain 2; NKSF; NKSF2; p40; IL12 p40-Carboxyterminal end;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Recombinant Antibodies
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Dog
  • Equine
  • Feline
  • Ferret
  • Hamster
  • Horse
  • Human
  • Marmoset
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Sheep
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Rat
  • Sf21 Insect Cell
  • Spodoptera Frugiperda
  • Yeast
  • C
  • Flag
  • hFc
  • His
  • Avi
  • Strep
  • TwinStrep
  • DDK
  • Fc
  • GST
  • His (Fc)
  • His(C
  • ter)
  • His|GST
  • His|T7
  • human|IgG1|Fc
  • Myc
  • MYC
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL12B-141H Active Recombinant Human IL12B Protein, His-tagged(C-ter) E.coli His(C-ter)
Human Il12b-750H Active Recombinant Human Il12b Protein, Fc Chimera Mammalian cells Fc
Human IL12B-180H Active Recombinant Human IL12B Protein (Ile23-Ser328), C-His tagged, Animal-free, Carrier-free E.coli C-His Ile23-Ser328
Human IL12B-220H Recombinant Human IL12B Sf21 Insect Cell N/A
Human IL12B-29638TH Recombinant Human IL12B, His-tagged E.coli His
Human IL12B-145H Active Recombinant Human IL12B protein(Met1-Ser328), His-tagged HEK293 C-His Met1-Ser328
Human IL12B-310H Recombinant Human IL12B protein, Fc-tagged HEK293 human/IgG1/Fc Ile23-Ser328
Human IL12B-177H Recombinant Human Interleukin 12B E.coli N/A
Human IL12B-43H Recombinant Human IL12B, His-tagged E.coli His
Human IL12B-670H Recombinant Human Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) CHO N/A
Human IL12B-272H Recombinant Human IL12B, StrepII-tagged Human Cell Strep II 23-328, 306 a.a.
Human IL12B-35H Recombinant Human Interleukin 12B, Fc-Tagged E.coli Fc
Human IL12B-172H Recombinant Human IL12B protein, His-tagged HEK293 His Ile23-Ser328
Human IL12A & IL12B-357H Active Recombinant Human IL12A & IL12B protein HEK293 N/A Met1-Ser219 & Met1-Ser328
Human IL12B-179H Recombinant Human IL12B Protein, DDK-tagged Insect Cell DDK
Human IL12B-2731HCL Recombinant Human IL12B cell lysate Human Cell N/A
Human IL12A & IL12B-1908HCL Recombinant Human IL12A & IL12B cell lysate Human Cell N/A
Human IL12B-1441H Recombinant Human IL12B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL12B-3091H Recombinant Human IL12B protein, GST-tagged E.coli GST 23-328aa
Human DMABT-H19271 Rat Anti-IL12B Monoclonal Antibody Rat N/A
Human CAB-T9002H Recombinant Anti-Human IL 12B Monoclonal Antibody N/A
Human IL12B-2290H Recombinant Human IL12B Protein, His-tagged E.coli N-His Val30-Ser320
Human IL12B-77H Recombinant Human IL12B Protein Human Cell
Human IL12B-502H Recombinant Human IL12B Protein 328
Human IL12B-131HG Active GMP Recombinant Human IL12B protein HEK293 DNA sequence encoding Human IL-12B(NP_002178.2) was expressed with His tag at the C-terminal.
Human IL12B-1164H Recombinant Human IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL12B-4303H Recombinant Human IL12B Protein (Met1-Ser328), C-His tagged Mammalian cells C-His Met1-Ser328
Human IL12B-128HG Active GMP Recombinant Human IL12B Protein Insect Cell N/A
Human IL12B-1267HFL Recombinant Full Length Human IL12B Protein, C-Flag-tagged Mammalian cells Flag
Human IL12B-322H Recombinant Human IL12B Protein, Fc-tagged HEK293 Fc 328
Human IL12B-181I Active Recombinant Human IL12B Protein HEK293
Human IL12B-1608H Active Recombinant Human IL12B protein, Fc-tagged HEK293 Fc Ile23-Ser328
Human IL12B-503H Recombinant Human IL12B Protein, Fc-tagged Fc 328
Human IL12B-4305H Recombinant Human IL12B Protein (Ile23-Ser328), C-His tagged Mammalian cells C-His Ile23-Ser328
Human IL12B-1164H-B Recombinant Human IL12B Protein Pre-coupled Magnetic Beads HEK293
Human IL12B-4304H Recombinant Human IL12B Protein (Ile23-Ser328), C-Flag tagged Mammalian cells C-Flag Ile23-Ser328
Human IL12B-178H Active Recombinant Human IL12B Protein (Ile1-Cys327), C-His tagged, Animal-free, Carrier-free HEK293 C-His Ile1-Cys327
Human IL12B-125H Recombinant Human IL12B and IL12A Protein, Ile23-Ser328, Arg23-Ser219 Protein, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Ile23-Ser328 (IL-12B) /Arg23-Ser219 (IL-12A)
Mouse Il12b-644M Active Recombinant Mouse Interleukin 12b Spodoptera Frugiperda N/A
Mouse Il12b-8693M Active Recombinant Mouse Il12b protein, His-tagged HEK293 His Met1-Ser335
Mouse Il12b-643M Active Recombinant Mouse Interleukin 12b Spodoptera Frugiperda N/A
Mouse Il12b-5647M Active Recombinant Mouse Interleukin 12b, His-tagged Mammalian cells His
Mouse Il12b-01M Active Recombinant Mouse Il12b Protein, His-Tagged E.coli His
Mouse Il12b-1236M Active Recombinant Mouse Il12b Protein Insect Cell
Mouse Il12b-738M Recombinant Mouse Il12b protein(Met1-Ser335), hFc-tagged HEK293 C-hFc Met1-Ser335
Mouse IL12B-435M Recombinant Mouse Il12b, LEVLFQ tagged Human Cell His
Mouse IL23A-159M Recombinant Mouse IL23A protein, His-tagged HEK293 C-His Met1-Ala196&Met1-Ser335
Mouse Il12b-178M Recombinant Murine Interleukin 12b E.coli N/A
Mouse Il12b-847M Recombinant Mouse Il12b protein, His & T7-tagged E.coli His/T7 Val35~Glu302 (Accession # P43432)
Mouse Il12b-348M Recombinant Mouse Il12b, Fc-tagged CHO Fc
Mouse IL12A & IL12B-1779MCL Recombinant Mouse IL12A & IL12B Overexpression Lysate(Met 1-Ala 215&Met 1-Ser 335) HEK293 C-hFc Met 1-Ala 215&Met 1-Ser 335
Mouse IL12A & IL12B-1780MCL Recombinant Mouse IL12A & IL12B Overexpression Lysate(Met 1-Ala 215&Met 1-Ser 335) HEK293 C-His Met 1-Ala 215&Met 1-Ser 335
Mouse IL12A & IL12B-1782MCL Recombinant Mouse IL12A & IL12B Overexpression Lysate(Met 1-Ala 215&Met 1-Ser 335) HEK293 C-His-hFc Met 1-Ala 215&Met 1-Ser 335
Mouse IL12A & IL12B-1781MCL Recombinant Mouse IL12A & IL12B Overexpression Lysate(Met 1-Ala 215&Met 1-Ser 335) HEK293 C-His-hFc Met 1-Ala 215&Met 1-Ser 335
Mouse IL12B-1101MCL Recombinant Mouse IL12B cell lysate Human Cell N/A
Mouse Il12b-1235M Active Recombinant Mouse Il12b Protein Insect Cell
Mouse Il12b-4492M-B Recombinant Mouse Il12b Protein Pre-coupled Magnetic Beads HEK293
Mouse Il12b-4492M Recombinant Mouse Il12b Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il12b-142M Recombinant Active Mouse IL12B Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Il12b-1237M Recombinant Mouse Il12b Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse IL12B-82M Recombinant Mouse IL12B Protein Human Cell
Mouse IL12B-0308M Active Recombinant Mouse IL12B protein HEK293 N/A Met1-Ser335
Mouse Il12b-4054M Recombinant Mouse Il12b Protein (Met23-Ser335), C-Strep tagged Mammalian cells C-Strep Met23-Ser335
Mouse Il12b-6739M Recombinant Mouse Il12b Protein (Met1-Ser335), C-TwinStrep tagged Mammalian cells C-TwinStrep Met1-Ser335
Mouse Il12b-257I Active Recombinant Mouse Il12b Protein CHO
Mouse IL12B-1607M Active Recombinant Mouse IL12B protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Met23-Ser335
Mouse Il12b-48M Active Recombinant Mouse Il12b Protein (Met23-Ser335), C-His tagged, Animal-free, Carrier-free E.coli C-His Met23-Ser335
Mouse Il12b-5694M Recombinant Mouse Il12b Protein (Met23-Ser335), C-His tagged Mammalian cells C-His Met23-Ser335
Rat Il12b&Il12a-748R Active Recombinant Rat Il12b&Il12a Sf21 Insect Cell N/A
Rat Il12b&Il23a-747R Active Recombinant Rat Il12b&Il23a Sf21 Insect Cell N/A
Rat Il12b-849R Recombinant Rat Il12b protein, His & T7-tagged E.coli His/T7 Val30~Cys311 (Accession # G3V9Y5)
Rat Il12b-1104R Recombinant Rat Il12b Protein, Fc-tagged HEK293 Fc
Rat Il23a&Il12b-556R Recombinant Rat Il23a&Il12b Human Cell N/A Met1-Ala196 & Met1-Ser335
Rat Il12b-86R Recombinant Rat Interleukin 12b Insect Cell N/A
Rat Il12b-8789R Recombinant Rat Il12b, His tagged Human Cell His
Rat IL12B-1197RCL Recombinant Rat IL12B cell lysate Human Cell N/A
Rabbit IL12B-1028R Recombinant Rabbit IL12B protein, His-tagged HEK293 His Met1-Asn324
Dog IL12B-845D Recombinant Dog IL12B protein, His & T7-tagged E.coli His/T7 Ile23~Ser329 (Accession # Q28268)
Bovine IL12B-233B Recombinant Bovine Interleukin 12B Yeast N/A
Canine IL12B-03C Active Recombinant Canine IL12B protein, His-tagged Mammalian cells His
Canine IL12B-3C-B Recombinant Canine IL12B Protein Pre-coupled Magnetic Beads HEK293
Canine IL12B-3C Recombinant Canine IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle IL12B-844C Recombinant Cattle IL12B protein, His & T7-tagged E.coli His/T7 Met23~Ser327 (Accession # P46282)
Cynomolgus Monkey IL12B-614C Recombinant Cynomolgus IL12B Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey IL12A & IL12B-001CCL Recombinant Cynomolgus IL12A & IL12B cell lysate Human Cell N/A
Cynomolgus Monkey IL12B-361C-B Recombinant Cynomolgus Monkey IL12B Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey IL12B-361C Recombinant Cynomolgus Monkey IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Equine IL12B-100E Recombinant Equine IL-12 p40 Yeast N/A
Feline IL12B-902F Active Recombinant Feline IL12B Protein, His-tagged Mammalian cells His Ile23-Ser329
Feline IL12B&IL12A-903F Active Recombinant Feline IL12B&IL12A Sf21 Insect Cell N/A
Feline IL12B-5F-B Recombinant Feline IL12B Protein Pre-coupled Magnetic Beads HEK293
Feline IL12B-5F Recombinant Feline IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Ferret IL12B-014F Recombinant Ferret IL12B Protein, Met1-Ser329, C-His tagged HEK293 C-His Met1-Ser329
Hamster Il12b-020H Recombinant Hamster Il12b Protein, Met1-Ser327, C-His tagged HEK293 C-His Met1-Ser327
Horse IL12B-846H Recombinant Horse IL12B protein, His & T7-tagged E.coli His/T7 Ile23~Ser329 (Accession # Q9XSQ5)
Marmoset IL12B-1381M Acitve Recombinant Marmoset IL12B protein(Met1-Asn328), hFc-tagged HEK293 C-hFc Met1-Asn328
Marmoset IL23A-162M Recombinant Marmoset IL23A & IL12B, His tagged Human Cell Fc
Marmoset IL12B-154M Recombinant Marmoset IL12B, Fc tagged Human Cell His
Marmoset IL12B-1000MCL Recombinant Marmoset IL12B cell lysate Human Cell N/A
Rhesus Macaque IL12B-2230R Recombinant Rhesus monkey IL12B Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL12B-2051R-B Recombinant Rhesus Macaque IL12B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL12B-2051R Recombinant Rhesus Macaque IL12B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sheep IL12B-4330S Recombinant Sheep IL12B Protein Yeast N/A 305aa
Sheep IL12B-576S Recombinant Sheep IL12B Protein (23-327 aa), His-tagged E.coli His 23-327 aa
Sheep IL12B-5437S Recombinant Sheep IL12B protein, His-tagged Yeast His 23-327aa
Pig IL12B-848P Recombinant Pig IL12B protein, His & GST-tagged E.coli His/GST Ile23~Asn324 (Accession # Q28938)
Pig IL12B-84S Recombinant Swine IL-12 p40 Yeast N/A
Chicken IL12B-7124C Recombinant Chicken IL12B Mammalian Cell His
Chicken IL12B-1001C Recombinant Chicken IL12B Protein, His-tagged E.coli N-His Gln21-Arg315
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IL12B Related Signal Pathway

IL12B involved in several pathways and played different roles in them. We selected most pathways IL12B participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionBMP7B;RELT;IL10RA;BMPR1B;LIF;KITLG;PDGFB;IFNA16;IFNAR2
Toll-like receptor signaling pathwayMAPK11;IFNB;RAC1A;IFNAR1;IRAK4;LBP;TLR4BB;FADD;MAPK10
RIG-I-like receptor signaling pathwayDAK;IFNA3;DDX58;RELA;TMEM173;RNF207B;PL10;MAPK13;MAPK8B
Jak-STAT signaling pathwayGRB2B;LEPR;CSF3;CRFB2;IFNGR2;STAT6;RAF1;IL13RA2;PTPN11B
Type I diabetes mellitusLTA;HLA-C;Fasl;HLA-DMB;IL1B;HLA-DMA;HLA-DRA;ICA1;TNF
PertussisITGB1;IL1B;PYCARD;ITGA5;RELA;MAPK12;MAPK1;CD14;C1QB
LegionellosisNAIP6;NLRC4;CXCL2;ITGB2L;SAR1A;CR1;NAIP1;C3;EEF1G
LeishmaniasisH2-AB1;MAPK1;IFNG;TGFB1;FCGR3A;NCF4;NFKBIA;C3;ITGB1
Chagas disease (American trypanosomiasis)MAPK1;PPP2R2A;PPP2R2C;PPP2CA;BDKRB2;IFNGR2;IFNGR1;GNAI3;TLR6
African trypanosomiasisGNAQ;MYD88;APOL1;IL12A;IL6;VCAM1;ICAM1;TLR9;Fasl
ToxoplasmosisHSPA1L;H2-AB1;HLA-DOB;LAMB2;MAPK9;MAPK11;GNAI2;LAMA2;SOCS1
AmoebiasisC8A;PRKCB;IFNG;LAMB4;AASS;COL4A3;GNAS;SERPINB1;IL10
TuberculosisITGAX;RAB7A;HLA-DRB4;PPP3CA;RAB5B;HLA-DQA2;VDR;ATP6V0D1;EEA1
MeaslesIL2RB;cgr2b;PIK3CA;IFNA8;IFIH1;Ifna15;IL12A;IFNA16;IRAK4
Influenza AFURIN;IFNA8;EIF2AK2;IL1B;MYD88;AKT2;MAP2K6;PIK3R2;IRF9
Herpes simplex infectionPVRL1B;MAP3K7;TAF10;JAK2A;OAS1A;IFNA5;RNASEL;BF2;IFIT1
Proteoglycans in cancerDDX5;PLCE1;IGF1R;THBS1;RRAS2;HSPB2;EZR;HRAS;WNT3
Inflammatory bowel disease (IBD)IL23;RORC;IL23R;IL12RB1;IFNGR2;RORA;FOXP3;TLR2;TNF
Allograft rejectionHLA-F;Il2;Fasl;IL12B;HLA-C;HLA-DRB5;HLA-DQA1;HLA-DPA1;HLA-DQB1

IL12B has several biochemical functions, for example, contributes_to cytokine activity, cytokine receptor activity, contributes_to growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12B itself. We selected most functions IL12B had, and list some proteins which have the same functions with IL12B. You can find most of the proteins on our site.

Function Related Protein
contributes_to cytokine activityCRLF1;IL12B;CLCF1;IL12A
cytokine receptor activityIL12RB2;IL1RL1;IL31RA;IL20RB;F3B;CSF3R;CRFB15;Ifnlr1;LEPR
contributes_to growth factor activityIL12B;IL12A
identical protein bindingRELA;KCNIP2;ROBO2;CLDN9;PACSIN2;MSTN;CALCA;PSMA7;RAF1
interleukin-12 alpha subunit bindingIL12BA;IL12B
interleukin-12 receptor bindingJAK2;IL12BA;IL12A;IL12B
contributes_to interleukin-12 receptor bindingIL23R;IL12B;IL12RB1
contributes_to interleukin-23 receptor bindingIL23;Il23a; Il12b;IL12B
protein bindingIGF2BP3;TPRKB;HEY1;HOXA3;DCUN1D4;RFX3;UBE2V1;CLEC18A;EXOC3
protein heterodimerization activitySEPHS1;CRLF1;PML;HIST1H2BM;KCNK9;CAV2;TCF3A;H2AFB1;OSTA
protein homodimerization activityIL6R;RAB11FIP3;CRTAM;ADRA2C;XCL1;ABAT;ALDH1A3;TERF1;TMEM173

IL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12B.

IL23A; IL12A; Il23a; IL12RB1; IL12RB1

Gene Family

IL

Research Area

Related articles

Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
Could you explain the use of ChIP-seq in studying IL12B transcriptional regulation? 05/12/2021

ChIP-seq identifies regulatory elements controlling IL12B gene expression.

Can you elaborate on the use of reporter assays to monitor IL12B promoter activity? 05/02/2021

Reporter assays monitor IL12B promoter activity under varying conditions.

What methods evaluate IL12B's response to different pathogenic stimuli in primary cells? 10/30/2020

Primary cell stimulation assays gauge IL12B response to pathogens.

How does siRNA knockdown of IL12B elucidate its role in immune cell activation? 05/25/2020

siRNA knockdown uncovers IL12B's role in immune cell activation pathways.

How does recombinant protein expression and purification aid in IL12B functional studies? 04/30/2020

Recombinant protein expression enables functional IL12B studies in vitro.

How does co-immunoprecipitation validate IL12B's association with signaling partners? 04/12/2018

Co-IP validates IL12B's binding to specific signaling partners.

What techniques are employed to analyze the impact of IL12B genetic variants on protein function? 12/03/2017

Genetic variant analysis reveals impacts on IL12B protein function.

How does flow cytometry reveal IL12B's expression dynamics in different immune cell subsets? 10/31/2017

Flow cytometry profiles IL12B expression across diverse immune cell types.

What experimental approaches determine IL12B's cytokine secretion kinetics upon stimulation? 09/29/2017

Cytokine secretion assays measure IL12B's response kinetics to stimuli.

What are the methods to assess IL12B's protein-protein interactions in a cellular context? 08/22/2017

Co-IP and immunoprecipitation assess IL12B's interactions with other proteins.

Customer Reviews (3)

Write a review
Reviews
04/08/2020

    Good for cytokine assays.

    01/06/2020

      Effective in Th2 cell differentiation.

      01/12/2019

        High yield in expression.

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