Recombinant Cynomolgus monkey CD86 Protein, Fc-tagged

Cat.No. : CD86-593C
Product Overview : Recombinant Cynomolgus monkey CD86 protein with Fc tag was expressed in HEK293.
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Description : This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
Source : HEK293
Species : Cynomolgus monkey
Tag : Fc
Form : Lyophilized
Molecular Mass : 52 kDa
Protein Length : 324
AA Sequence : TMGLSNTLFVMAFLLSGAAPLKIQA YFNETADLPCQFANSQNRSLSELVV FWQNQENLVLNEVYLGKEKFDSVHS KYMGRTSFDPESWTLRLHNLQIKDK GLYQCIIHHKRPTGMIRIHQMNSEL SVLANFSQPEIVPISNITENMYINL TCSSIHGYPEPEKMSVLLRTKNSTI EYDGVMQKSQDNVTELYDVSISLSV SFPDVTSNMTIFCVLETDKTQLLSS PFSIELEDPQPPPDHIPWITAVLPT VIICVMAFCLILWKWKKKKQPRNSY KCGTNTMEREESEQTKKREKINVPE RSDEAQCVFKSLKTPSCDKSDTRF
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : CD86 CD86 molecule [ Macaca mulatta (Rhesus monkey) ]
Official Symbol : CD86
Synonyms : CD86; CD86 molecule; T-lymphocyte activation antigen CD86; CD86 antigen;
Gene ID : 714390
mRNA Refseq : NM_001042644
Protein Refseq : NP_001036109
UniProt ID : Q9BDM4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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01/09/2022

    With the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.

    05/30/2021

      Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.

      12/08/2017

        The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.

        Q&As (5)

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        Are there any ongoing clinical trials involving CD86 inhibitors? 02/18/2023

        Yes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.

        How does CD86 contribute to transplant medicine? 02/03/2021

        In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.

        How does CD86 influence the balance between Th1 and Th2 immune responses? 08/26/2019

        CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.

        Can CD86 be used as a prognostic marker in certain diseases? 12/29/2018

        There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.

        How does CD86 influence the development of regulatory T cells (Tregs)? 10/02/2016

        CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.

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