CD86 Protein

CD86

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CD86

Official Full Name Cluster of Differentiation 86
Background Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymph
Synonyms Cluster of Differentiation 86; CD86; B7-2; B7.2; B70; CD28LG2; LAB72; MGC34413; T-lymphocyte activation antigen CD86; BU63; FUN-1; B7-2 antigen; OTTHUMP00000215511; OTTHUMP00000215512; OTTHUMP00000215513; OTTHUMP00000215514; OTTHUMP00000215515; CD28 antigen ligand 2; activation B7-2 antigen; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Cynomolgus/Rhesus macaque
    • Homo sapiens (Human)
    • Human
    • Monkey
    • Mouse
    • Mus musculus (Mouse)
    • Oryctolagus cuniculus (Rabbit)
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • CHO cells
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293F
    • Human Cell
    • Human Cells
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Avi
    • Fc
    • DDK
    • His
    • DYKDDDDK
    • Fc Chimera
    • Fc(C-ter)
    • Fc/Avi
    • Fc/His
    • GST
    • His(C-ter)
    • Flag
    • StrepII
    • T7
    • His-Avi
    • HlgG1 Fc
    • human
    • IgG1
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD86-204H Active Recombinant Human CD86, Fc Chimera Mammalian cells Fc Chimera
    Human CD86-355H Active Recombinant Human CD86, MIgG2a Fc-tagged CHO Fc
    Human CD86-356H Active Recombinant Human CD86, HIgG1 Fc-tagged CHO Fc
    Human CD86-575H Active Recombinant Human CD86 Protein, Fc Chimera CHO Fc
    Human CD86-581H Active Recombinant Human CD86 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human CD86-583H Active Recombinant Human CD86, His-tagged, Biotinylated Human Cell His
    Human CD86-584H Active Recombinant Human CD86, Fc-tagged, Biotinylated Human Cell Fc
    Human CD86-585H Active Recombinant Human CD86 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Mouse CD86-365M Active Recombinant Mouse CD86, MIgG2a Fc-tagged CHO Fc
    Rat Cd86-960R Active Recombinant Rat Cd86 Protein, Fc Chimera Mammalian cells Fc
    Human CD86-051H Active Recombinant Human CD86 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi
    Human CD86-019H Recombinant Human CD86 Protein, Fc-tagged HEK293 Fc
    Human CD86-0873H Recombinant Human CD86 Protein, His-Flag-StrepII-Tagged Human Cell His/Flag/StrepII
    Human CD86-0875H Recombinant Human CD86 Protein, GST-Tagged Wheat Germ GST
    Human CD86-10981H Recombinant Human CD86, GST-tagged E.coli GST
    Human CD86-111H Recombinant Human CD86 Protein, His-tagged HEK293 His
    Human CD86-112H Recombinant Human CD86 Protein, DDK/His-tagged HEK293 DDK/His
    Human CD86-132H Recombinant Human CD86, Fc-tagged CHO Fc
    Human CD86-133H Recombinant Human CD86 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CD86-2228H Recombinant Human CD86, His tagged Human Cell His
    Human CD86-2229H Recombinant Human CD86 protein, His-tagged HEK293 His
    Human CD86-27891TH Recombinant Human CD86 Wheat Germ N/A
    Human CD86-55H Recombinant Human CD86, Fc-His tagged Human Cell Fc/His
    Human CD86-7780H Recombinant Human CD86 protein, His & T7-tagged E.coli His/T7
    Mouse Cd86-1706M Recombinant Mouse CD86 Antigen Sf21 Insect Cell N/A
    Mouse Cd86-2281M Recombinant Mouse Cd86 protein, His-tagged HEK293 His
    Mouse Cd86-2282M Recombinant Mouse Cd86, Fc-His tagged Human Cell Fc/His
    Mouse Cd86-7781M Recombinant Mouse Cd86 protein, His & T7-tagged E.coli His/T7
    Rat Cd86-4087R Recombinant Rat Cd86, His tagged Human Cell His
    Cynomolgus Monkey CD86-138C Recombinant Cynomolgus CD86, Fc tagged Human Cell Fc/His
    Cynomolgus Monkey CD86-139C Recombinant Cynomolgus CD86, His tagged Human Cell Fc
    Cynomolgus Monkey CD86-171C Recombinant Cynomolgus CD86, His-tagged HEK293 His
    Rhesus Macaque CD86-752R Recombinant Rhesus monkey CD86 Protein, His-tagged Mammalian Cell His
    Chicken CD86-3308C Recombinant Chicken CD86 Mammalian Cell His
    Cynomolgus/Rhesus macaque CD86-172C Recombinant Cynomolgus/Rhesus macaque CD86 protein, His-tagged (HPLC-verified) HEK293 His
    Cynomolgus/Rhesus macaque CD86-370C Recombinant Cynomolgus/Rhesus macaque CD86 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CD86-2619HCL Recombinant Human CD86 cell lysate Human Cell N/A
    Mouse CD86-2598MCL Recombinant Mouse CD86 cell lysate Human Cell N/A
    Rat CD86-1971RCL Recombinant Rat CD86 cell lysate Human Cell N/A
    Cynomolgus Monkey CD86-1013CCL Recombinant Cynomolgus CD86 cell lysate Human Cell N/A
    Monkey CD86-138CAF488 Recombinant Monkey CD86 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Monkey CD86-138CAF555 Recombinant Monkey CD86 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Monkey CD86-138CAF647 Recombinant Monkey CD86 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Monkey CD86-138CF Recombinant Monkey CD86 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Monkey CD86-139CAF488 Recombinant Cynomolgus CD86 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Monkey CD86-139CAF555 Recombinant Cynomolgus CD86 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Monkey CD86-139CAF647 Recombinant Cynomolgus CD86 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Monkey CD86-139CF Recombinant Cynomolgus CD86 Protein, His-tagged, FITC conjugated HEK293 His
    Human CD86-151H Recombinant Human CD86 Protein, Fc-tagged Human cells Fc
    Human CD86-152H Recombinant Human CD86 Protein, Fc-tagged Human cells Fc
    Human CD86-2228HAF488 Recombinant Human CD86 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Human CD86-2228HAF555 Recombinant Human CD86 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Human CD86-2228HAF647 Recombinant Human CD86 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Human CD86-2228HF Recombinant Human CD86 Protein, His-tagged, FITC conjugated HEK293 His
    Mouse Cd86-2281MAF488 Recombinant Mouse Cd86 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Mouse Cd86-2281MAF555 Recombinant Mouse Cd86 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Mouse Cd86-2281MAF647 Recombinant Mouse Cd86 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Mouse Cd86-2281MF Recombinant Mouse Cd86 Protein, His-tagged, FITC conjugated HEK293 His
    Mouse Cd86-2282MAF488 Recombinant Mouse Cd86 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
    Mouse Cd86-2282MAF555 Recombinant Mouse Cd86 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
    Mouse Cd86-2282MAF647 Recombinant Mouse Cd86 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
    Mouse Cd86-2282MF Recombinant Mouse Cd86 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
    Human CD86-253H Recombinant Human CD86 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CD86-254H Recombinant Human CD86 Protein, His-tagged Human Cells His
    Human CD86-3086HF Recombinant Full Length Human CD86 Protein, GST-tagged In Vitro Cell Free System GST
    Mouse Cd86-39M Recombinant Mouse CD86 Protein (ECD), Fc-tagged(C-ter) HEK293 Fc(C-ter)
    Rat Cd86-4087RAF488 Recombinant Rat Cd86 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Rat Cd86-4087RAF555 Recombinant Rat Cd86 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Rat Cd86-4087RAF647 Recombinant Rat Cd86 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Rat Cd86-4087RF Recombinant Rat Cd86 Protein, His-tagged, FITC conjugated HEK293 His
    Mouse Cd86-40M Recombinant Mouse CD86 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter)
    Human CD86-55HAF488 Recombinant Human CD86 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
    Human CD86-55HAF555 Recombinant Human CD86 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
    Human CD86-55HAF647 Recombinant Human CD86 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
    Human CD86-55HF Recombinant Human CD86 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
    Human CD86-68HF Recombinant Full Length Human CD86 Protein In Vitro Cell Free System
    Mouse Cd86-703M Recombinant Mouse Cd86 Protein, His-tagged E.coli N-His
    Human CD86-704H Recombinant Human CD86 Protein, His-tagged HEK293F N-His
    Homo sapiens (Human) RFL21607HF Recombinant Full Length Human T-Lymphocyte Activation Antigen Cd86(Cd86) Protein, His-Tagged E.coli expression system His
    Mus musculus (Mouse) RFL31563MF Recombinant Full Length Mouse T-Lymphocyte Activation Antigen Cd86(Cd86) Protein, His-Tagged E.coli expression system His
    Oryctolagus cuniculus (Rabbit) RFL77OF Recombinant Full Length Rabbit T-Lymphocyte Activation Antigen Cd86(Cd86) Protein, His-Tagged E.coli expression system His
    Human CD86-1095H Recombinant Human CD86 Protein (Met1-His239), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Human CD86-109HG GMP Recombinant Human CD86 protein, His-tagged HEK293 His
    Human CD86-2228HB Recombinant Human CD86 protein, His-tagged, Biotinylated HEK293 His
    Human CD86-422H Recombinant Human CD86 Protein (Met1-His239), His-Fc-tagged, Biotinylated HEK293 His/Fc
    Human CD86-580H Recombinant Human CD86 protein, His-Avi-tagged HEK293 His-Avi
    Mouse CD86-322M Recombinant Mouse CD86 protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse CD86-799M Recombinant Mouse CD86 Protein (Met1-Glu245), His-tagged, Biotinylated HEK293 His

    CD86 involved in several pathways and played different roles in them. We selected most pathways CD86 participated on our site, such as Cell adhesion molecules (CAMs), Toll-like receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD86 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) CLDNA; CDH3; HLA-DPB1; CLDN5B; NRXN1; CDH15; CLDN2; HLA-F; CD4; CLDN5
    Toll-like receptor signaling pathway TBK1; RIPK1; MAP2K2B; MAPK10; TLR1LB; TLR4BB; CXCL9; CD40; TLR1; FOS
    Intestinal i ITGB7; CD80; CD28; ITGA4; Il2; HLA-DPA1; BLA; BLB2; MHC2A; CCL25
    ne network for IgA production CCL27B; HLA-DPA1; MHC2DEB; HLA-DOA; HLA-DQA2; CXCL12B; BLB1; HLA-DRA; CXCR4; CD28
    Type I diabetes mellitus H2-Q10; Il2; HLA-DPA1; HLA-E; HLA-DRB5; INS2; CD86; HLA-G; H2-AA; CD28
    Transcriptional misregulation in cancer BCL2A1A; SIX1; NCOR1; FLI1; NR4A3; ID2; ITGB7; CEBPE; NGFR; MET
    Autoi HLA-C; Ifna15; PRF1; IFNA8; IFNA13; TSHB; HLA-DOA; HLA-G; HLA-DOB; IFNA14
    ne thyroid disease Il2; IFNA1; CD40LG; IFNA10; Fasl; Ifna11; HLA-DQA1; HLA-F; HLA-DQA2; HLA-DPA1
    Systemic lupus erythematosus HIST1H2BA; C1QB; HIST1H2BP; C1QA; HIST1H3F; HIST1H4C; HIST1H2AD; H2BFWT; HIST3H2A; ELANE
    Rheumatoid arthritis ATP6V1C1; ATP6V0D1; ATP6V1C2; CD80; CCL20; ATP6V1B2; TGFB2; TNF; CCL5; TNFSF11
    Allograft rejection HLA-DQA2; HLA-DRB5; HLA-DPB1; MICA; HLA-DQB1; FAS; H2-AA; IL12A; GZMB; HLA-DQA1
    Graft-versus-host disease KIR2DL3; HLA-E; IL1A; KIR3DL1; Il2; HLA-DQA2; TNF; KIR3DL2; HLA-DQA1; KIR2DL1
    Viral myocarditis CASP9; HLA-DRB5; HLA-DOB; CD40LG; LAMA2; HLA-DQB1; ACTG1; CD28; FYN; HLA-DMA

    CD86 has several biochemical functions, for example, coreceptor activity, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD86 itself. We selected most functions CD86 had, and list some proteins which have the same functions with CD86. You can find most of the proteins on our site.

    Function Related Protein
    coreceptor activity ACVR2A; IGSF1; PVRL2; HFE2; RGMD; CD8B; CD28; CXCR7; RGMB; CD80
    protein binding EIF2S1; SQSTM1; TRAM2; NUAK2; CIB4; CFH; RNH1; YEATS4; BLZF1; HNRPLL
    receptor activity GRIA3A; OR3A2; VMN1R43; OPN1SW; EIF2D; DERL1; TREM1; CADM4; RNF139; THBD
    receptor binding GIPC1; PLAT; HAO1; PVRL1B; DRD1A; MBL2; FLT3LG; IL1RAPL1; PECI; FGF24
    virus receptor activity SERPINB3; SERPINB4; EFNB3; CD4; CLEC5A; SLC10A1; DAG1; ITGA5; SCARB2; LAMP1

    CD86 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD86 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD86.

    CTLA4; CD80; ECE2; PARP1

    Huizinga, TWJ; et al. Personalized medicine in rheumatoid arthritis: is the glass half full or half empty?. JOURNAL OF INTERNAL MEDICINE 277:178-187(2015).
    Wang, L; Sun, XG; et al. Increased Numbers of Circulating ICOS+ Follicular Helper T and CD38(+) Plasma Cells in Patients with Newly Diagnosed Primary Biliary Cirrhosis. DIGESTIVE DISEASES AND SCIENCES 60:405-413(2015).

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