cd86

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cd86

Official Full Name Cluster of Differentiation 86
Background Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymph
Synonyms Cluster of Differentiation 86; CD86; B7-2; B7.2; B70; CD28LG2; LAB72; MGC34413; T-lymphocyte activation antigen CD86; BU63; FUN-1; B7-2 antigen; OTTHUMP00000215511; OTTHUMP00000215512; OTTHUMP00000215513; OTTHUMP00000215514; OTTHUMP00000215515; CD28 antigen ligand 2; activation B7-2 antigen; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Cynomolgus/Rhesus macaque
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NS0
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Avi
    • Fc
    • DDK
    • His
    • Fc Chimera
    • GST
    • Flag
    • StrepII
    • T7
    • HlgG1 Fc
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD86-1095H Recombinant Human CD86 Protein (Met1-His239), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Mouse CD86-322M Recombinant Mouse CD86 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CD86-422H Recombinant Human CD86 Protein (Met1-His239), His-Fc-tagged, Biotinylated HEK293 His/Fc
    Mouse CD86-799M Recombinant Mouse CD86 Protein (Met1-Glu245), His-tagged, Biotinylated HEK293 His
    Human CD86-019H Recombinant Human CD86 Protein, Fc-tagged HEK293 Fc
    Human CD86-0873H Recombinant Human CD86 Protein, His-Flag-StrepII-Tagged Human Cell His/Flag/StrepII
    Human CD86-0875H Recombinant Human CD86 Protein, GST-Tagged Wheat Germ GST
    Human CD86-10981H Recombinant Human CD86, GST-tagged E.coli GST
    Human CD86-111H Recombinant Human CD86 Protein, His-tagged HEK293 His
    Human CD86-112H Recombinant Human CD86 Protein, DDK/His-tagged HEK293 DDK/His
    Human CD86-132H Recombinant Human CD86, Fc-tagged CHO Fc
    Human CD86-133H Recombinant Human CD86 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CD86-204H Recombinant Human CD86, Fc Chimera NS0 Fc Chimera
    Human CD86-2228H Recombinant Human CD86, His tagged Human Cell His
    Human CD86-2229H Recombinant Human CD86 protein, His-tagged HEK293 His
    Human CD86-2619HCL Recombinant Human CD86 cell lysate Human Cell N/A
    Human CD86-27891TH Recombinant Human CD86 Wheat Germ N/A
    Human CD86-355H Recombinant Human CD86, MIgG2a Fc-tagged CHO Fc
    Human CD86-356H Recombinant Human CD86, HIgG1 Fc-tagged CHO Fc
    Human CD86-55H Recombinant Human CD86, Fc-His tagged Human Cell Fc/His
    Human CD86-575H Recombinant Human CD86 Protein, Fc Chimera CHO Fc
    Human CD86-581H Recombinant Human CD86 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human CD86-583H Recombinant Human CD86, His-tagged, Biotinylated Human Cell His
    Human CD86-584H Recombinant Human CD86, Fc-tagged, Biotinylated Human Cell Fc
    Human CD86-585H Recombinant Human CD86 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human CD86-7780H Recombinant Human CD86 protein, His & T7-tagged E.coli His/T7
    Mouse Cd86-1706M Recombinant Mouse CD86 Antigen Sf21 Insect Cell N/A
    Mouse Cd86-2281M Recombinant Mouse Cd86 protein, His-tagged HEK293 His
    Mouse Cd86-2282M Recombinant Mouse Cd86, Fc-His tagged Human Cell Fc/His
    Mouse CD86-2598MCL Recombinant Mouse CD86 cell lysate Human Cell N/A
    Mouse CD86-365M Recombinant Mouse CD86, MIgG2a Fc-tagged CHO Fc
    Mouse Cd86-7781M Recombinant Mouse Cd86 protein, His & T7-tagged E.coli His/T7
    Rat CD86-1971RCL Recombinant Rat CD86 cell lysate Human Cell N/A
    Rat Cd86-4087R Recombinant Rat Cd86, His tagged Human Cell His
    Rat Cd86-960R Recombinant Rat Cd86 Protein, Fc Chimera NS0 Fc
    Cynomolgus Monkey CD86-1013CCL Recombinant Cynomolgus CD86 cell lysate Human Cell N/A
    Cynomolgus Monkey CD86-138C Recombinant Cynomolgus CD86, Fc tagged Human Cell Fc/His
    Cynomolgus Monkey CD86-139C Recombinant Cynomolgus CD86, His tagged Human Cell Fc
    Cynomolgus Monkey CD86-171C Recombinant Cynomolgus CD86, His-tagged HEK293 His
    Cynomolgus/Rhesus macaque CD86-172C Recombinant Cynomolgus/Rhesus macaque CD86 protein, His-tagged (HPLC-verified) HEK293 His
    Cynomolgus/Rhesus macaque CD86-370C Recombinant Cynomolgus/Rhesus macaque CD86 protein, Fc-tagged HEK293 human/IgG1/Fc
    Rhesus Macaque CD86-752R Recombinant Rhesus monkey CD86 Protein, His-tagged Mammalian Cell His
    Chicken CD86-3308C Recombinant Chicken CD86 Mammalian Cell His

    cd86 involved in several pathways and played different roles in them. We selected most pathways cd86 participated on our site, such as Cell adhesion molecules (CAMs), Toll-like receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with cd86 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) NEO1; MADCAM1; CLDN18; ITGA6; CD40LG; ICAM3; NCAM1B; OCLNA; CLDN14; CLDNG
    Toll-like receptor signaling pathway PIK3CB; MAP3K7; CRFB2; IFNAR1; TRAF3; MAPK8; TLR1LA; IL8L2; STAT1; MYD88
    Intestinal i BLB1; CCR10; CD40LG; CCR9A; HLA-DPB1; IL5; TNFRSF13B; CCL25B; ICOS; CXCL12A
    ne network for IgA production HLA-DPB1; CXCR4A; CXCR4; HLA-DOA; IL5; CD40LG; ICOSLG; MHC2A; MADCAM1; CD40
    Type I diabetes mellitus HLA-DQA2; HLA-F; HSPD1; HLA-DRB4; H2-Q10; CD80; HLA-C; HLA-DRB3; Il2; IFNG
    Transcriptional misregulation in cancer GOLPH3; IGF1R; NFKBIZ; MLLT3; ID2; H3F3C; MDM2; RXRA; JMJD1C; RARA
    Autoi H2-Q10; H2-AB1; IFNA7; FASLG; IFNA21; CD80; CD86; IFNA8; IL5; IFNA14
    ne thyroid disease IFNA21; TSHB; H2-AA; CD40; IFNA2; HLA-DQA2; CD80; HLA-DRB5; HLA-E; IFNA12
    Systemic lupus erythematosus HIST1H3A; HIST2H4A; HIST1H4A; CD40LG; HIST1H3C; HLA-DPB1; ACTN2; CD86; FCGR2A; TROVE2
    Rheumatoid arthritis H2-AB1; Ctsl; CXCL6; HLA-DQA2; IL6; ATP6V1B1; HLA-DMA; ATP6V1D; ATP6V0D2; GM-CSF
    Allograft rejection HLA-DMA; HLA-DQB1; HLA-DRA; H2-Q10; HLA-G; HLA-F; HLA-DPA1; HLA-DRB1; CD40LG; HLA-DRB4
    Graft-versus-host disease HLA-DQA1; HLA-DRB5; IL1B; FAS; HLA-F; KIR2DL3; CD80; HLA-A; HLA-DRB4; Il2
    Viral myocarditis HLA-DQA2; CYCS; FYN; CASP9; ACTB; SGCB; Casp3; MYH7; H2-Q10; SGCG

    cd86 has several biochemical functions, for example, coreceptor activity, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cd86 itself. We selected most functions cd86 had, and list some proteins which have the same functions with cd86. You can find most of the proteins on our site.

    Function Related Protein
    coreceptor activity CD8A; RGMA; CD8B; ACKR3B; CCR5; PVRL2; RGMD; RGMB; CXCR6; CXCR7B
    protein binding GPR19; INPPL1; MKRN2; PLEC; SREBF2; ENTPD5; CHD; FYCO1; PPP2R5C; SNTA1
    receptor activity VMN1R54; ANPEP; PROCR; FPR1; ADCYAP1R1; THRAP3; GRIN3B; CNTNAP1; FAS; CD200R2
    receptor binding HFE2; PTPRD; IL28A; GNB2L1; POMC; FKBP1B; PLXNC1; PVRL2; WNT4A; ACOX1
    virus receptor activity CLDN1; ITGA2; HTR2A; CD209A; CR2; CD86; ITGAV; HYAL2; ITGB3; GYPA

    cd86 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd86 here. Most of them are supplied by our site. Hope this information will be useful for your research of cd86.

    CTLA4; CD80; ECE2; PARP1

    Huizinga, TWJ; et al. Personalized medicine in rheumatoid arthritis: is the glass half full or half empty?. JOURNAL OF INTERNAL MEDICINE 277:178-187(2015).
    Wang, L; Sun, XG; et al. Increased Numbers of Circulating ICOS+ Follicular Helper T and CD38(+) Plasma Cells in Patients with Newly Diagnosed Primary Biliary Cirrhosis. DIGESTIVE DISEASES AND SCIENCES 60:405-413(2015).

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