| Official Full Name | Cluster of Differentiation 86 |
| Background | Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymph |
| Synonyms | Cluster of Differentiation 86; CD86; B7-2; B7.2; B70; CD28LG2; LAB72; MGC34413; T-lymphocyte activation antigen CD86; BU63; FUN-1; B7-2 antigen; OTTHUMP00000215511; OTTHUMP00000215512; OTTHUMP00000215513; OTTHUMP00000215514; OTTHUMP00000215515; CD28 antigen ligand 2; activation B7-2 antigen; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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cd86 involved in several pathways and played different roles in them. We selected most pathways cd86 participated on our site, such as Cell adhesion molecules (CAMs), Toll-like receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with cd86 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | CLDN5; NEO1; HLA-G; F11R.1; NRCAMA; CLDN18; MHC2DCB; CLDN17; LRRC4B; NCAM1A |
| Toll-like receptor signaling pathway | CASP8; MAPK1; TLR4BA; AKT3A; IFNA13; MAPK12; MAP2K2A; IFNA4; TICAM2; CCL5 |
| Intestinal i | HLA-DOB; BLB2; MHC2DCB; BMA2; CCL28; TGFB1A; H2-AB1; CD80; HLA-DRA; TNFSF13 |
| ne network for IgA production | HLA-DRB5; HLA-DQB1; HLA-DRB1; BMA1; CCL27B; CXCL12A; ICOS; HLA-DRB4; TGFB1A; IL-15RA |
| Type I diabetes mellitus | HLA-DOB; HLA-DMB; HSPD1; HLA-F; GZMB; TNF; HLA-DQA1; HLA-DRB5; HLA-DRB4; GAD1 |
| Transcriptional misregulation in cancer | SPINT1; Pdgfa&Pdgfb; FEV; CCNT1; MLL1; PPARG; LMO2; BCL2A1; BMP2K; MMP9 |
| Autoi | HLA-DOB; HLA-DPA1; TG; H2-Q10; IL4; PRF1; Ifna15; IFNA10; HLA-A; IFNA6 |
| ne thyroid disease | CD40; HLA-DMB; HLA-DOB; IFNA10; HLA-DPB1; FASLG; IL4; IFNA21; IFNA17; Ifna11 |
| Systemic lupus erythematosus | HIST1H3A; GM14482; H2AFY; TRIM21; HIST1H4J; HIST1H4C; H2-AB1; C8B; C6; H2AFJ |
| Rheumatoid arthritis | Il23a; MMP1A; CTLA4; ATP6V1G2; TGFB2; CXCL6; ITGB2; IL18; CD80; HLA-DRA |
| Allograft rejection | IL12B; CD86; HLA-DMB; FASLG; HLA-DQB1; HLA-C; IFNG; HLA-DRA; HLA-DQA2; H2-AB1 |
| Graft-versus-host disease | HLA-DRA; HLA-B; IL1A; H2-AA; Fasl; TNF; HLA-DRB1; GZMB; HLA-DQB1; CD80 |
| Viral myocarditis | HLA-DRB4; CAV1; CASP9; HLA-DMA; SGCA; HLA-E; HLA-DRB1; HLA-B; SGCD; CD40LG |
cd86 has several biochemical functions, for example, coreceptor activity, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cd86 itself. We selected most functions cd86 had, and list some proteins which have the same functions with cd86. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| coreceptor activity | PVRL2; RAMP3; CXCR7; CXCR7B; CD28; CD8A; TMIGD2; CXCR4; PVRL1; CD86 |
| protein binding | EIF3F; LARS; DDB2; USP33; NOL11; BTBD1; DDB1; CAV3; EPN2; MSH6 |
| receptor activity | TIGIT; RTN4RL1; FKBP3; VAC14; ADIPOR2; V1RA8; OPN1SW; ITGB1B; ITGB1B.2; CALCR |
| receptor binding | SNX17; FGF13A; FGF12B; CLCF1; APOL2; CNPY4; MLN; EHHADH; UFD1L; TAC4 |
| virus receptor activity | LDLR; DPP4; ACE2; F11R; ITGA2; ANPEP; SELPLG; SLC52A2; CLDN1; CXADR |
cd86 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd86 here. Most of them are supplied by our site. Hope this information will be useful for your research of cd86.
CTLA4; CD80; ECE2; PARP1
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