CD86

  • Official Full Name

    Cluster of Differentiation 86

  • Overview

    Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymph
  • Synonyms

    Cluster of Differentiation 86; CD86; B7-2; B7.2; B70; CD28LG2; LAB72; MGC34413; T-lymphocyte activation antigen CD86; BU63; FUN-1; B7-2 antigen; OTTHUMP00000215511; OTTHUMP00000215512; OTTHUMP00000215513; OTTHUMP00000215514; OTTHUMP00000215515; CD28 antigen ligand 2; activation B7-2 antigen; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Cynomolgus/Rhesus
  • Cynomolgus/Rhesus macaque
  • Homo sapiens (Human)
  • Human
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rabbit
  • Rat
  • Rhesus Macaque
  • CHO
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • Human Cell
  • Human cells
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • Avi|Fc
  • C
  • Fc
  • hFc
  • His
  • mFc
  • 6×His
  • DDK|His
  • DYKDDDDK
  • Fc Chimera
  • Fc(C
  • ter)
  • Avi
  • Fc|His
  • GST
  • His (Fc)
  • His(C
  • His|Avi
  • His|Fc
  • His|Flag|StrepII
  • His|T7
  • HlgG1 Fc
  • human|IgG1|Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD86-575H Active Recombinant Human CD86 Protein, Fc Chimera CHO Fc
Human CD86-356H Active Recombinant Human CD86, HIgG1 Fc-tagged CHO Fc
Human CD86-581H Active Recombinant Human CD86 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
Human CD86-584H Active Recombinant Human CD86, Fc-tagged, Biotinylated Human Cell Fc
Human CD86-583H Active Recombinant Human CD86, His-tagged, Biotinylated Human Cell His
Human CD86-355H Active Recombinant Human CD86, MIgG2a Fc-tagged CHO Fc
Human CD86-585H Active Recombinant Human CD86 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
Human CD86-204H Active Recombinant Human CD86, Fc Chimera Mammalian cells Fc Chimera
Human CD86-051H Active Recombinant Human CD86 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi
Human CD86-27891TH Recombinant Human CD86 Wheat Germ N/A
Human CD86-132H Recombinant Human CD86, Fc-tagged CHO Fc
Human CD86-2229H Recombinant Human CD86 protein, His-tagged HEK293 His
Human CD86-2228H Recombinant Human CD86, His tagged Human Cell His
Human CD86-112H Recombinant Human CD86 Protein, DDK/His-tagged HEK293 DDK/His
Human CD86-133H Recombinant Human CD86 protein, Fc-tagged HEK293 human/IgG1/Fc
Human CD86-55H Recombinant Human CD86, Fc-His tagged Human Cell Fc/His
Human CD86-7780H Recombinant Human CD86 protein, His & T7-tagged E.coli His/T7
Human CD86-019H Recombinant Human CD86 Protein, Fc-tagged HEK293 Fc
Human CD86-111H Recombinant Human CD86 Protein, His-tagged HEK293 His
Human CD86-0873H Active Recombinant Human CD86 Protein, His-Flag-StrepII-Tagged Human Cell His/Flag/StrepII
Human CD86-10981H Recombinant Human CD86, GST-tagged E.coli GST
Human CD86-0875H Recombinant Human CD86 Protein, GST-Tagged Wheat Germ GST
Human CD86-2619HCL Recombinant Human CD86 cell lysate Human Cell N/A
Human CD86-580H Recombinant Human CD86 protein, His-Avi-tagged HEK293 His-Avi
Human CD86-1095H Recombinant Human CD86 Protein (Met1-His239), HlgG1 Fc-tagged HEK293 HlgG1 Fc
Human CD86-422H Recombinant Human CD86 Protein (Met1-His239), His-Fc-tagged, Biotinylated HEK293 His/Fc
Human CD86-2228HAF647 Recombinant Human CD86 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Human CD86-254H Recombinant Human CD86 Protein, His-tagged Human Cells His
Human CD86-55HAF488 Recombinant Human CD86 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
Human CD86-2228HB Recombinant Human CD86 protein, His-tagged, Biotinylated HEK293 His
Human CD86-109HG Active GMP Recombinant Human CD86 protein HEK293
Human CD86-152H Recombinant Human CD86 Protein, Fc-tagged Human cells Fc
Human CD86-704H Recombinant Human CD86 Protein, His-tagged HEK293F N-His
Human CD86-151H Recombinant Human CD86 Protein, Fc-tagged Human cells Fc
Human CD86-253H Recombinant Human CD86 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CD86-2228HAF555 Recombinant Human CD86 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Human CD86-176H-B Recombinant Human CD86 Protein Pre-coupled Magnetic Beads HEK293
Human CD86-55HAF555 Recombinant Human CD86 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
Human CD86-2228HAF488 Recombinant Human CD86 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Human CD86-2228HF Recombinant Human CD86 Protein, His-tagged, FITC conjugated HEK293 His
Human CD86-2903H Active Recombinant Human CD86 protein, Fc-tagged HEK293 Fc
Human CD86-55HAF647 Recombinant Human CD86 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
Human CD86-0802H Recombinant Human CD86 Protein (Leu26-Ala134), N-His tagged E.coli N-His
Human CD86-68HF Recombinant Full Length Human CD86 Protein In Vitro Cell Free System
Human CD86-531H Recombinant Human CD86 Protein (Leu26-Pro247), C-hFc-tagged HEK293 C-hFc
Human CD86-55HF Recombinant Human CD86 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
Human CD86-532H Recombinant Human CD86 Protein (Leu26-Pro247), C-mFc and 6×His-tagged HEK293 C-mFc and 6×His
Human CD86-186H Recombinant Human CD86 Protein, C-His-tagged E.coli C-His
Human CD86-3086HF Recombinant Full Length Human CD86 Protein, GST-tagged In Vitro Cell Free System GST
Human CD86-176H Recombinant Human CD86 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD86-594H Recombinant Human CD86 Protein HEK293
Human CD86-2624H Active Recombinant Human CD86 protein, His-tagged HEK293 His
Human CD86-595H Recombinant Human CD86 Protein, Fc-tagged HEK293 Fc
Human CD86-0932H Recombinant Human CD86 Protein (Met1-Pro247), C-His tagged Mammalian cells C-His
Mouse CD86-365M Active Recombinant Mouse CD86, MIgG2a Fc-tagged CHO Fc
Mouse Cd86-2282M Recombinant Mouse Cd86, Fc-His tagged Human Cell Fc/His
Mouse Cd86-7781M Recombinant Mouse Cd86 protein, His & T7-tagged E.coli His/T7
Mouse Cd86-2281M Active Recombinant Mouse Cd86 protein(Met1-Glu245), His-tagged HEK293 C-His
Mouse Cd86-1706M Recombinant Mouse CD86 Antigen Sf21 Insect Cell N/A
Mouse CD86-2598MCL Recombinant Mouse CD86 cell lysate Human Cell N/A
Mouse CD86-799M Recombinant Mouse CD86 protein, His-tagged, Biotinylated HEK293 His
Mouse Cd86-39M Recombinant Mouse CD86 Protein (ECD), Fc-tagged(C-ter) HEK293 Fc(C-ter)
Mouse Cd86-2282MAF488 Recombinant Mouse Cd86 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
Mouse CD86-322M Recombinant Mouse CD86 protein, Fc-tagged HEK293 human/IgG1/Fc
Mouse Cd86-703M Recombinant Mouse Cd86 Protein, His-tagged E.coli N-His
Mouse Cd86-2281MAF488 Recombinant Mouse Cd86 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Mouse Cd86-40M Recombinant Mouse CD86 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter)
Mouse Cd86-2281MF Recombinant Mouse Cd86 Protein, His-tagged, FITC conjugated HEK293 His
Mouse Cd86-5624M Recombinant Mouse Cd86 Protein (Val26-Glu245), C-Fc tagged Mammalian cells C-Fc
Mouse Cd86-2282MF Recombinant Mouse Cd86 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
Mouse CD86-597M Recombinant Mouse CD86 Protein, Fc-tagged HEK293 Fc
Mouse Cd86-2281MAF647 Recombinant Mouse Cd86 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Mouse Cd86-5625M Recombinant Mouse Cd86 Protein (Val24-Lys244), C-His tagged Mammalian cells C-His
Mouse Cd86-2282MAF647 Recombinant Mouse Cd86 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
Mouse Cd86-2281MAF555 Recombinant Mouse Cd86 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Mouse Cd86-2282MAF555 Recombinant Mouse Cd86 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
Mouse CD86-596M Recombinant Mouse CD86 Protein HEK293
Rat Cd86-960R Active Recombinant Rat Cd86 Protein, Fc Chimera Mammalian cells Fc
Rat Cd86-4087R Active Recombinant Rat Cd86 protein, His-tagged HEK293 His
Rat CD86-1971RCL Recombinant Rat CD86 cell lysate Human Cell N/A
Rat Cd86-4087RAF488 Recombinant Rat Cd86 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Rat Cd86-4087RAF555 Recombinant Rat Cd86 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Rat Cd86-6837R Recombinant Rat Cd86 Protein (Vla29-Lys247), C-His tagged Mammalian cells C-His
Rat Cd86-4087RAF647 Recombinant Rat Cd86 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Rat Cd86-10R-B Recombinant Rat Cd86 Protein Pre-coupled Magnetic Beads HEK293
Rat Cd86-4087RF Recombinant Rat Cd86 Protein, His-tagged, FITC conjugated HEK293 His
Rat Cd86-10R Recombinant Rat Cd86 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Monkey CD86-139CF Recombinant Cynomolgus CD86 Protein, His-tagged, FITC conjugated HEK293 His
Monkey CD86-139CAF488 Recombinant Cynomolgus CD86 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Monkey CD86-139CAF555 Recombinant Cynomolgus CD86 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Monkey CD86-138CAF488 Recombinant Monkey CD86 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Monkey CD86-138CAF647 Recombinant Monkey CD86 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Monkey CD86-138CAF555 Recombinant Monkey CD86 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Monkey CD86-139CAF647 Recombinant Cynomolgus CD86 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Monkey CD86-138CF Recombinant Monkey CD86 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Rabbit CD86-5397R Recombinant Rabbit CD86 Protein (Ala23-Arg246), C-His tagged Mammalian cells C-His
Cynomolgus Monkey CD86-139C Recombinant Cynomolgus CD86, His tagged Human Cell Fc
Cynomolgus Monkey CD86-138C Recombinant Cynomolgus CD86, Fc tagged Human Cell Fc/His
Cynomolgus Monkey CD86-1013CCL Recombinant Cynomolgus CD86 cell lysate Human Cell N/A
Cynomolgus monkey CD86-592C Recombinant Cynomolgus monkey CD86 Protein HEK293
Cynomolgus monkey CD86-593C Recombinant Cynomolgus monkey CD86 Protein, Fc-tagged HEK293 Fc
Cynomolgus/Rhesus CD86-171C Recombinant Cynomolgus/Rhesus CD86 protein, His-tagged HEK293 His
Cynomolgus/Rhesus CD86-1289C Recombinant Cynomolgus/Rhesus CD86 protein(Met1-His239), hFc-tagged HEK293 C-hFc
Cynomolgus/Rhesus macaque CD86-370C Recombinant Cynomolgus/Rhesus macaque CD86 protein, Fc-tagged HEK293 human/IgG1/Fc
Cynomolgus/Rhesus macaque CD86-172C Recombinant Cynomolgus/Rhesus macaque CD86 protein, His-tagged (HPLC-verified) HEK293 His
Homo sapiens (Human) RFL21607HF Recombinant Full Length Human T-Lymphocyte Activation Antigen Cd86(Cd86) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL31563MF Recombinant Full Length Mouse T-Lymphocyte Activation Antigen Cd86(Cd86) Protein, His-Tagged E.coli expression system His
Oryctolagus cuniculus (Rabbit) RFL77OF Recombinant Full Length Rabbit T-Lymphocyte Activation Antigen Cd86(Cd86) Protein, His-Tagged E.coli expression system His
Rhesus Macaque CD86-752R Recombinant Rhesus monkey CD86 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD86-578R-B Recombinant Rhesus Macaque CD86 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD86-578R Recombinant Rhesus Macaque CD86 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CD86-3308C Recombinant Chicken CD86 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD86 Related Articles
  • CD86 Related Gene Family
  • CD86 Related Research Area

CD86 involved in several pathways and played different roles in them. We selected most pathways CD86 participated on our site, such as Cell adhesion molecules (CAMs), Toll-like receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD86 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CD6;NEGR1;NEO1A;MPZL1L;SPN;CLDND;CD226;SELP;ICOS
Toll-like receptor signaling pathwayCCL4L2;CXCL9;LY96;MAPK14B;IFNA14;TAB2;IFNB;MAPK8B;PIK3CG
Intestinal iTGFB1;IL4;Il2;IL6;CXCR4A;TNFRSF13B;CCR9A;CXCL12;CD40
ne network for IgA productionMHC2DAB;CCL27B;CXCR4B;HLA-DRB3;CCL25;CD28;H2-AA;CXCL12B;Il2
Type I diabetes mellitusHLA-DQA2;HLA-G;HLA-DRB1;INS2;HLA-A;Fasl;HLA-F;INS1;HLA-C
Transcriptional misregulation in cancerMMP3;PROM1;LMO2;GOLPH3L;SP1;RELA;CEBPE;SIX1;JMJD1C
AutoiH2-AB1;IFNA10;IL4;TSHB;IFNA5;IFNA16;HLA-DQA2;Ifna11;H2-AA
ne thyroid diseaseIFNA5;HLA-DMA;HLA-B;IFNA2;Ifna15;CD40;TPO;HLA-G;CD28
Systemic lupus erythematosusC8G;HIST1H4F;H2-AB1;HIST1H2BD;H3F3A;GM6026;SNRPD1;TNF;HIST1H2BL
Rheumatoid arthritisCD80;ATP6V1F;MMP3;Ctsl;ATP6V0B;H2-AB1;ATP6V0E1;IL15;ATP6V1B2
Allograft rejectionIl2;HLA-DPA1;CD40LG;HLA-DMB;CD40;IL10;IL12B;TNF;H2-AA
Graft-versus-host diseaseHLA-DRB1;HLA-C;FAS;HLA-DQB1;KIR2DL3;HLA-DOB;IL1A;KIR3DL1;CD28
Viral myocarditisHLA-DRB4;EIF4G2;SGCG;ICAM1;HLA-DQA1;PRF1;RAC2;CD40LG;HLA-DRA

CD86 has several biochemical functions, for example, coreceptor activity, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD86 itself. We selected most functions CD86 had, and list some proteins which have the same functions with CD86. You can find most of the proteins on our site.

Function Related Protein
coreceptor activityTMIGD2;CXCR6;RAMP3;RGMB;ACKR3B;TGFBR3;CD8B;RAMP1;CD28
protein bindingRNF126;AMOTL2A;HNRNPR;APOB;UBA7;ATP1A1;AGTR1A;CSF2RB;LMX1B
receptor activityTNPO3;CSF2RB;CD46;ITGB3B;CD33;APLNR;CD200;GRIA4B;PVRL1B
receptor bindingCRTAM;FGF1B;Icosl;LAMA2;TDGF1;RSPO1;C1QTNF2;WNT2BB;CADM4
virus receptor activitySCARB2;CLEC4M;CD46;MOG;DPP4;ANPEP;CD209;SLC52A2;CD4

CD86 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD86 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD86.

CTLA4; CD80; ECE2; PARP1

Huizinga, TWJ; et al. Personalized medicine in rheumatoid arthritis: is the glass half full or half empty?. JOURNAL OF INTERNAL MEDICINE 277:178-187(2015).
Wang, L; Sun, XG; et al. Increased Numbers of Circulating ICOS+ Follicular Helper T and CD38(+) Plasma Cells in Patients with Newly Diagnosed Primary Biliary Cirrhosis. DIGESTIVE DISEASES AND SCIENCES 60:405-413(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any ongoing clinical trials involving CD86 inhibitors? 02/18/2023

Yes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.

How does CD86 contribute to transplant medicine? 02/03/2021

In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.

How does CD86 influence the balance between Th1 and Th2 immune responses? 08/26/2019

CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.

Can CD86 be used as a prognostic marker in certain diseases? 12/29/2018

There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.

How does CD86 influence the development of regulatory T cells (Tregs)? 10/02/2016

CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.

Customer Reviews (3)

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Reviews
01/09/2022

    With the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.

    05/30/2021

      Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.

      12/08/2017

        The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.

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