Recombinant Full Length Human AXL Protein, C-Flag-tagged

• Cat.No.: AXL-592HFL
• Product Overview: Recombinant Full Length Human AXL Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 98.2 kDa
• AA Sequence: MAWRCPRMGRVPLAWCLALCGWACM APRGTQAEESPFVGNPGNITGARGL TGTLRCQLQVQGEPPEVHWL RDGQILELADSTQTQVPLGEDEQDD WIVVSQLRITSLQLSDTGQYQCLVF LGHQTFVSQPGYVGLEGLPY FLEEPEDRTVAANTPFNLSCQAQGP PEPVDLLWLQDAVPLATAPGHGPQR SLHVPGLNKTSSFSCEAHNA KGVTTSRTATITVLPQQPRNLHLVS RQPTELEVAWTPGLSGIYPLTHCTL QAVLSDDGMGIQAGEPDPPE EPLTSQASVPPHQLRLGSLHPHTPY HIRVACTSSQGPSSWTHWLPVETPE GVPLGPPENISATRNGSQAF VHWQEPRAPLQGTLLGYRLAYQGQD TPEVLMDIGLRQEVTLELQGDGSVS NLTVCVAAYTAAGDGPWSLP VPLEAWRPGQAQPVHQLVKEPSTPA FSWPWWYVLLGAVVAAACVLILALF LVHRRKKETRYGEVFEPTVE RGELVVRYRVRKSYSRRTTEATLNS LGISEELKEKLRDVMVDRHKVALGK TLGEGEFGAVMEGQLNQDDS ILKVAVKTMKIAICTRSELEDFLSE AVCMKEFDHPNVMRLIGVCFQGSER ESFPAPVVILPFMKHGDLHS FLLYSRLGDQPVYLPTQMLVKFMAD IASGMEYLSTKRFIHRDLAARNCML NENMSVCVADFGLSKKIYNG DYYRQGRIAKMPVKWIAIESLADRV YTSKSDVWSFGVTMWEIATRGQTPY PGVENSEIYDYLRRGNRLKQ PADCLDGLYALMSRCWELNPQDRPS FTELREDLENTLKALPPAQEPDEIL YVNMDEGGGYPEPPGAAGGA
  DPPTQPDPKDSCSCLTAAEVHPAGR YVLCPSTTPSPAQPADRGSPAAPGQ EDGATRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane

Gene Information

• Gene Name: AXL AXL receptor tyrosine kinase [ Homo sapiens (human) ]
• Official Symbol: AXL
• Synonyms: ARK; UFO; JTK11; Tyro7
• Gene ID: 558
• mRNA Refseq: NM_021913.5
• Protein Refseq: NP_068713.2
• MIM: 109135
• UniProt ID: P30530