axl
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  • Official Full Name
  • AXL receptor tyrosine kinase
  • Background
  • The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
  • Synonyms
  • AXL; AXL receptor tyrosine kinase; UFO; JTK11; tyrosine-protein kinase receptor UFO; AXL oncogene; AXL transforming sequence/gene;
Cat.#:AXL-5894HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AXL Protein, MYC/DDK-tagged
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Cat.#:AXL-10086HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AXL, GST-tagged
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Cat.#:AXL-1049HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AXL protein, GST-tagged
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Cat.#:AXL-190HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human AXL, Fc Chimera
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Cat.#:AXL-202HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AXL (R499C), GST-tagged
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Cat.#:AXL-36HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AXL protein, Flag-tagged, Biotinylated
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Cat.#:AXL-379HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AXL protein, GST-tagged
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Cat.#:AXL-537HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human AXL, Fc-tagged, Biotinylated
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Cat.#:AXL-538HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human AXL, Fc-tagged
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Cat.#:AXL-769HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human AXL, His tagged
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Cat.#:AXL-770HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human AXL protein, His-tagged
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Cat.#:AXL-920HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human AXL Protein, DDK/His-tagged
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Cat.#:AXL-921HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human AXL Protein, DDK/His-tagged
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Cat.#:Axl-132MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Axl, Fc-His tagged
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Cat.#:Axl-626MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Axl, His tagged
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Cat.#:Axl-1820RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Axl protein, His & T7-tagged
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Cat.#:AXL-249HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AXL Receptor Tyrosine Kinase, His-tagged, Active
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Cat.#:AXL-539HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AXL Receptor Tyrosine Kinase, GST-tagged
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Cat.#:Axl-499MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse AXL Receptor Tyrosine Kinase
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Cat.#:AXL-2281HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human AXL cell lysate
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Cat.#:AXL-2476MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse AXL cell lysate
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Cat.#:CSC-P0527Tag:
Source (Host):Species:Human
Product nameAnti-Human AXL MAb Stable Cell Line-CHO
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Cat.#:CSC-P0528Tag:
Source (Host):Species:Human
Product nameAnti-Human AXL F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0529Tag:
Source (Host):Species:Human
Product nameAnti-Human AXL scFv Stable Cell Line-CHO
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Involved Pathway

AXL involved in several pathways and played different roles in them. We selected most pathways AXL participated on our site, such as Signal Transduction, Signaling by VEGF, VEGFA-VEGFR2 Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signal Transduction
KLHL12; OMG; CRHB; ROR2; TAGAPB; RLN1; CDC42EP2; RAB6A; APOM; QRFPR
Signaling by VEGF
SHB; AXL; JUPA; DSCAMA; NRP2; NRP2A; NRP2B
VEGFA-VEGFR2 Pathway
AXL; DSCAMA; JUPA

Protein Function

AXL has several biochemical functions, for example, ATP binding, phosphatidylserine binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXL itself. We selected most functions AXL had, and list some proteins which have the same functions with AXL. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCG1; MYO6A; KIF5A; SMYHC1; MYO7A; GSK3AA; SYN1; ULK4; UBE2G1B; ATP8A1
Function phosphatidylserine binding
Related Protein SYT4; SCARB1; SDPR; CPNE6; THBS1; ANXA13; MARK1; FCHO2; AP1S2; TRIM72
Function protein binding
Related Protein DYRK4; PATL1; NCOR1; TCEA2; NIPSNAP3A; USP54; KCTD1; ATP4B; PAGE2; PHYHD1
Function protein heterodimerization activity
Related Protein ARNT; TAL1; NR4A1; ADRA2A; SOX4; HIST1H2B8; CAPN2; NFYBB; MAFGB; SLC3A1
Function protein tyrosine kinase activity
Related Protein LYN; PTK2AB; MAP2K5; PTK2B; EGFR; FGFR3; FGFR4; PTK7; PDGFRB; FER
Function transmembrane receptor protein tyrosine kinase activity
Related Protein EGFR; EPHA4A; INSRA; NTRK3A; ERBB4A; ERBB2; DDR1; ROR1; IGF1RA; DDR2
Function virus receptor activity
Related Protein HSPA1A; PVR; CLDN1; SCARB1; TNFRSF4; SIVA1; GPR172B; ITGA5; PVRL4; CD46

Interacting Protein

AXL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXL here. Most of them are supplied by our site. Hope this information will be useful for your research of AXL.
EGFR; PLCG1; PIK3R1; GRB2; GAS6; abl-tide

AXL Related Articles

Yu, Z; Li, XC; et al. 3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines. MOLECULAR DIVERSITY 19:135-147(2015).
Albert, R; Kristof, E; et al. Triamcinolone regulated apopto-phagocytic gene expression patterns in the clearance of dying retinal pigment epithelial cells. A key role of Mertk in the enhanced phagocytosis. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1850:435-446(2015).