AXL

  • Official Full Name

    AXL receptor tyrosine kinase

  • Overview

    The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
  • Synonyms

    AXL; AXL receptor tyrosine kinase; UFO; JTK11; tyrosine-protein kinase receptor UFO; AXL oncogene; AXL transforming sequence/gene;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • 6×His
  • hFc
  • His
  • DDK|His
  • DYKDDDDK
  • Fc
  • Fc Chimera
  • Avi
  • Flag
  • GST
  • His (Fc)
  • His|T7
  • mFc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AXL-190H Active Recombinant Human AXL, Fc Chimera Mammalian cells Fc Chimera
Human AXL-538H Active Recombinant Human AXL, Fc-tagged Human Cell Fc
Human AXL-537H Active Recombinant Human AXL, Fc-tagged, Biotinylated Human Cell Fc
Human AXL-202H Active Recombinant Human AXL (R499C), GST-tagged Sf9 Insect Cell GST
Human AXL-535H Active Recombinant Human AXL protein, His-tagged HEK293 His Ala26-Pro440
Human AXL-27H Active Recombinant Human AXL(35-end) Protein, N-His-tagged Sf21 His 35-end
Human AXL-769H Recombinant Human AXL protein(Met1-Pro449), His-tagged HEK293 C-His Met1-Pro449
Human AXL-249H Recombinant Human AXL Receptor Tyrosine Kinase, His-tagged, Active Sf9 Insect Cell His
Human AXL-539H Recombinant Human AXL Receptor Tyrosine Kinase, GST-tagged Sf9 Insect Cell GST
Human AXL-920H Recombinant Human AXL Protein, DDK/His-tagged HEK293 DDK/His
Human AXL-10086H Recombinant Human AXL, GST-tagged E.coli GST C-term-350a.a.
Human AXL-1049H Recombinant Human AXL protein, GST-tagged Wheat Germ GST
Human AXL-770H Recombinant Human AXL protein, His-tagged HEK293 His 424
Human AXL-5894H Recombinant Human AXL Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AXL-379H Recombinant Human AXL protein, GST-tagged Insect Cell GST
Human AXL-36H Recombinant Human AXL protein, Flag-tagged, Biotinylated Insect Cell Flag
Human AXL-921H Recombinant Human AXL Protein, DDK/His-tagged HEK293 DDK/His
Human AXL-2281HCL Recombinant Human AXL cell lysate Human Cell N/A
Human AXL-584HB Recombinant Human AXL protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Ala26-Pro 449.
Human AXL-779H Recombinant Human AXL protein, His-tagged HEK293 His Ala 26 - Pro 449
Human AXL-536H Recombinant Human AXL protein, Fc-tagged HEK293 Fc Ala26-Pro440
Human AXL-2918H Recombinant Human AXL Protein(26-451aa(D266N)), His-tagged HEK293 C-His 26-451aa(D266N)
Human AXL-585H Recombinant Human AXL protein, His-Avi-tagged HEK293 His-Avi It contains Ala26-Pro 449.
Human AXL-048H Recombinant Human AXL protein, hFc-tagged HEK293 hFc Ala26-Trp451
Human AXL-088H Recombinant Human AXL Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human AXL-7544H Recombinant Human AXL protein(26-451aa), His-tagged HEK293 C-His 26-451aa
Human AXL-5599H Recombinant Human AXL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AXL-1519H Recombinant Human AXL Protein (Gly545-Ala894), N-His and N-SUMO tagged E.coli N-His and N-SUMO Gly545-Ala894
Human AXL-282H Recombinant Human AXL Protein, His-tagged E.coli N-His Gly29-Met269
Human AXL-9382H Recombinant Human AXL protein, His-tagged E.coli His Gly29~Met269
Human AXL-592HFL Recombinant Full Length Human AXL Protein, C-Flag-tagged Mammalian cells Flag
Human AXL-344H Recombinant Human AXL Protein (Ala26-Pro449), C-6×His-tagged HEK293 C-6×His Ala26-Pro449
Human Axl-2622H Active Recombinant Human Axl protein, His-tagged HEK293 His Glu33-Pro449
Human AXL-087H Recombinant Human AXL Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human Axl-813H Recombinant Human Axl Protein HEK293 1912
Human AXL-4983H Recombinant Human AXL Protein (Ala26-Pro449), C-His tagged Mammalian cells C-His Ala26-Pro449
Human Axl-2893H Active Recombinant Human Axl protein, Fc-tagged HEK293 Fc Ala 26-Trp 451
Human AXL-1536HF Recombinant Full Length Human AXL Protein, GST-tagged In Vitro Cell Free System GST 894 amino acids
Human AXL-167H-B Recombinant Human AXL Protein Pre-coupled Magnetic Beads HEK293
Human AXL-167H Recombinant Human AXL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AXL-1516H Recombinant Human AXL Protein (Met1-Pro449), C-His tagged Mammalian cells C-His Met1-Pro449
Human Axl-2892H Active Recombinant Human Axl protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Ala 26-Trp 451
Human AXL-0286H Recombinant Human AXL protein, mFc-tagged HEK293 mFc Met1-Pro449
Human AXL-2919H Recombinant Human AXL Protein(26-451aa(D266N)), hFc-tagged HEK293 C-hFc 26-451aa(D266N)
Mouse Axl-626M Recombinant Mouse AXL protein, His-tagged HEK293 His Met1-Pro443
Mouse Axl-499M Recombinant Mouse AXL Receptor Tyrosine Kinase Mammalian cells N/A
Mouse Axl-132M Recombinant Mouse Axl protein, His&hFc-tagged HEK293 His&hFc Met1-Pro443
Mouse AXL-2476MCL Recombinant Mouse AXL cell lysate Human Cell N/A
Mouse Axl-10522M-B Recombinant Mouse Axl Protein Pre-coupled Magnetic Beads HEK293
Mouse Axl-1792M Recombinant Mouse Axl Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Axl-133M Recombinant Mouse Axl(Ala19-Pro443) Protein, C-Fc-tagged HEK293 Fc
Mouse Axl-10522M Recombinant Mouse Axl Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Axl-1820R Recombinant Rat Axl protein, His & T7-tagged E.coli His/T7 Lys21~His202 (Accession # Q8VIA0)
Rat AXL-1330R Recombinant Rat AXL protein(Met1-Pro434), His-tagged HEK293 C-His Met1-Pro434
Cynomolgus Axl-2894C Recombinant Cynomolgus Axl protein, His-tagged HEK293 His Pro 27-Pro 293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

AXL involved in several pathways and played different roles in them. We selected most pathways AXL participated on our site, such as Signal Transduction, Signaling by VEGF, VEGFA-VEGFR2 Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signal TransductionCIT;DEPDC7;PDK4;DNAL4;GPR77;LRIG1;HCAR1-2;ARHGAP44;BCO2
Signaling by VEGFNRP2A;AXL;NRP2B;DSCAMA;NRP2;JUPA;SHB
VEGFA-VEGFR2 PathwayAXL;DSCAMA;JUPA

AXL has several biochemical functions, for example, ATP binding, phosphatidylserine binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXL itself. We selected most functions AXL had, and list some proteins which have the same functions with AXL. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCDK15;CSNK1E;IFIH1;PAPOLG;SMG1;MAPK8A;STK4;DCLK2;UBA6
phosphatidylserine bindingGAP43;CPNE1;CD300A;THBS1;FCHO2;SYTL2;PLCD1;OSBPL5;MFGE8
protein bindingMYO15;TNIP3;STYX;ITSN2;FSCN1;DEFA6;DTX3L;TMEM74;TRIM43
protein heterodimerization activityBCL2L2;MCL1;SYT16;ARNT;BOK;HIST1H3A;USF1;SUPT3H;H2AFY
protein tyrosine kinase activityPTK2AB;JAK2B;BMX;RET;CLK2;ZAP70;EGFR;PDGFRB;JAK2
transmembrane receptor protein tyrosine kinase activityFLT1;EPHB4;DDR2;NPTNB;ROS1;KDRL;LTK;CADM2B;INSRR
virus receptor activityLAMP1;ANPEP;ITGA2;ITGB3;IDE;PVRL2;SLC52A2;HSPA1A;SELPLG

AXL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXL here. Most of them are supplied by our site. Hope this information will be useful for your research of AXL.

EGFR; PLCG1; PIK3R1; GRB2; GAS6; abl-tide

Research Area

Related articles

Yu, Z; Li, XC; et al. 3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines. MOLECULAR DIVERSITY 19:135-147(2015).
Albert, R; Kristof, E; et al. Triamcinolone regulated apopto-phagocytic gene expression patterns in the clearance of dying retinal pigment epithelial cells. A key role of Mertk in the enhanced phagocytosis. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1850:435-446(2015).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All AXL Products

Required fields are marked with *

My Review for All AXL Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /
  • Service lnquiry:

Stay Updated on the Latest Bioscience Trends