| Description : |
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. |
| Source : |
HEK293 |
| Species : |
Human |
| Form : |
Lyophilized |
| Molecular Mass : |
140 kDa |
| Protein Length : |
1912 |
| AA Sequence : |
MVHVARLLLLLLTFFLRTDAETPPR FTRTPVDQTGVSGGVASFICQATGD PRPKIVWNKKGKKVSNQRFEVIEFD DGSGSVLRIQPLRTPRDEAIYECVA SNNVGEISVSTRLTVLREDQIPRGF PTIDMGPQLKVVERTRTATMLCAAS GNPDPEITWFKDFLPVDTSNNNGRI KQLRSESIGGTPIRGALQIEQSEES DQGKYECVATNSAGTRYSAPANLYV RELREVRRVPPRFSIPPTNHEIMPG GSVNITCVAVGSPMPYVKWMLGAED LTPEDDMPIGRNVLELNDVRQSANY TCVAMSTLGVIEAIAQITVKALPKP PGTPVVTESTATSITLTWDSGNPEP VSYYIIQHKPKNSEELYKEIDGVAT TRYSVAGLSPYSDYEFRVVAVNNIG RGPPSEPVLTQTSEQAPSSAPRDVQ ARMLSSTTILVQWKEPEEPNGQIQG YRVYYTMDPTQHVNNWMKHNVADSQ ITTIGNLVPQKTYSVKVLAFTSIGD GPLSSDIQVITQTGVPGQPLNFKAE PESETSILLSWTPPRSDTIANYELV YKDGEHGEEQRITIEPGTSYRLQGL KPNSLYYFRLAARSPQGLGASTAEI SARTMQSKPSAPPQDISCTSPSSTS ILVSWQPPPVEKQNGIITEYSIKYT AVDGEDDKPHEILGIPSDTTKYLLE QLEKWTEYRITVTAHTDVGPGPESL SVLIRTNEDVPSGPPRKVEVEAVNS TSVKVSWRSPVPNKQHGQIRGYQVH YVRMENGEPKGQPMLKDVMLADAQW EFDDTTEHDMIISGLQPETSYSLTV TAYTTKGDGARSKPKLVSTTGAVPG KPRLVINHTQMNTALIQWHPPVDTF GPLQGYRLKFGRKDMEPLTTLEFSE KEDHFTATDIHKGASYVFRLSARNK VGFGEEMVKEISIPEEVPTGFPQNL HSEGTTSTSVQLSWQPPVLAERNGI ITKYTLLYRDINIPLLPMEQLIVPA DTTMTLTGLKPDTTYDVKVRAHTSK GPGPYSPSVQFRTLPVDQVFAKNFH VKAVMKTSVLLSWEIPENYNSAMPF KILYDDGKMVEEVDGRATQKLIVNL KPEKSYSFVLTNRGNSAGGLQHRVT AKTAPDVLRTKPAFIGKTNLDGMIT VQLPEVPANENIKGYYIIIVPLKKS RGKFIKPWESPDEMELDELLKEISR KRRSIRYGREVELKPYIAAHFDVLP TEFTLGDDKHYGGFTNKQLQSGQEY VFFVLAVMEHAESKMYATSPYSDPV VSMDLDPQPITDEEEGLIWVVGPVL AVVFIICIVIAILLYKRKRAESDSR KSSIPNNKEIPSHHPTDPVELRRLN FQTPGMASHPPIPILELADHIERLK ANDNLKFSQEYESIDPGQQFTWEHS NLEVNKPKNRYANVIAYDHSRVLLS AIEGIPGSDYVNANYIDGYRKQNAY IATQGSLPETFGDFWRMIWEQRSAT VVMMTKLEERSRVKCDQYWPSRGTE THGLVQVTLLDTVELATYCVRTFAL YKNGSSEKREVRQFQFTAWPDHGVP EHPTPFLAFLRRVKTCNPPDAGPMV VHCSAGVGRTGCFIVIDAMLERIKH EKTVDIYGHVTLMRAQRNYMVQTED QYIFIHDALLEAVTCGNTEVPARNL YAYIQKLTQIETGENVTGMELEFKR LASSKAHTSRFISANLPCNKFKNRL VNIMPYESTRVCLQPIRGVEGSDYI NASFIDGYRQQKAYIATQGPLAETT EDFWRMLWEHNSTIVVMLTKLREMG REKCHQYWPAERSARYQYFVVDPMA EYNMPQYILREFKVTDARDGQSRTV RQFQFTDWPEQGVPKSGEGFIDFIG QVHKTKEQFGQDGPISVHCSAGVGR TGVFITLSIVLERMRYEGVVDIFQT VKMLRTQRPAMVQTEDQYQFSYRAA LEYLGSFDHYAT |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
