| Description : |
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Form : |
Liquid |
| Molecular Mass : |
88.77 kDa |
| Protein Length : |
574 amino acids |
| AA Sequence : |
MRDPGAAAPLSSLGLCALVLALLGA LSAGAGAQPYHGEKGISVPDHGFCQ PISIPLCTDIAYNQTILPNLLGHTN QEDAGLEVHQFYPLVKVQCSPELRF FLCSMYAPVCTVLDQAIPPCRSLCE RARQGCEALMNKFGFQWPERLRCEN FPVHGAGEICVGQNTSDGSGGPGGG PTAYPTAPYLPDLPFTALPPGASDG RGRPAFPFSCPRQLKVPPYLGYRFL GERDCGAPCEPGRANGLMYFKEEER RFARLWVGVWSVLCCASTLFTVLTY LVDMRRFSYPERPIIFLSGCYFMVA VAHVAGFLLEDRAVCVERFSDDGYR TVAQGTKKEGCTILFMVLYFFGMAS SIWWVILSLTWFLAAGMKWGHEAIE ANSQYFHLAAWAVPAVKTITILAMG QVDGDLLSGVCYVGLSSVDALRGFV LAPLFVYLFIGTSFLLAGFVSLFRI RTIMKHDGTKTEKLEKLMVRIGVFS VLYTVPATIVLACYFYEQAFREHWE RTWLLQTCKSYAVPCPPGHFPPMSP DFTVFMIKYLMTMIVGITTGFWIWS GKTLQSWRRFYHRLSHSSKGETAV |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
