FZD7
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Official Full Name
frizzled class receptor 7 -
Overview
Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008] -
Synonyms
FZD7;frizzled class receptor 7;FzE3;frizzled-7;fz-7;hFz7;frizzled homolog 7;frizzled family receptor 7;Frizzled, drosophila, homolog of, 7;frizzled 7, seven transmembrane spanning receptor
Recombinant Proteins
- Human
- Mouse
- Chicken
- Mus musculus
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- CHO
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- Fc
- Non
- His
- Flag
- GST
- Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FZD7-537H |
Active Recombinant Human FZD7 Protein, Fc-tagged
|
CHO | Human | Fc | Gln33 - Leu185 |
|
| Fzd7-589M |
Active Recombinant Mouse Frizzled Homolog 7 (Drosophila), Fc-tagged
|
Mammalian Cells | Mouse | Fc | 33-185 a.a. |
|
| FZD7-384H |
Active Recombinant Human FZD7 Full Length Transmembrane protein(Nanodisc)
|
HEK293 | Human | Non | Full L. |
|
| FZD7-12H | Recombinant Human FZD7 protein, Fc-tagged | HEK293 | Human | Fc | Gln33-Leu185 |
|
| FZD7-26288TH | Recombinant Human FZD7 | Wheat Germ | Human | Non | 99 amino acids |
|
| FZD7-5794C | Recombinant Chicken FZD7 | Mammalian Cells | Chicken | His |
|
|
| FZD7-6121M | Recombinant Mouse FZD7 Protein | Mammalian Cells | Mouse | His |
|
|
| FZD7-643H | Active Recombinant Human FZD7 protein, His-tagged | HEK293 | Human | His | Gln33-Leu185 |
|
| FZD7-6088HCL | Recombinant Human FZD7 293 Cell Lysate | HEK293 | Human | Non |
|
|
| FZD7-1113HFL | Recombinant Human FZD7 protein, His&Flag-tagged | HEK293 | Human | Flag&His | 1-574 aa |
|
| FZD7-1470H | Recombinant Human FZD7 protein(Gln33-Arg254), hFc-tagged | HEK293 | Human | Fc | 33-185 a.a. |
|
| FZD7-2166H | Recombinant Human FZD7 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| FZD7-258H | Recombinant Human FZD7 Protein, Fc-tagged | HEK293 | Human | Fc | 574 |
|
| FZD7-2704H | Active Recombinant Human FZD7 protein, hFc&His-tagged | HEK293 | Human | Fc&His | Gln33-Leu185 |
|
| FZD7-4598H | Recombinant Human FZD7 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| FZD7-5090HF | Recombinant Full Length Human FZD7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 574 amino acids |
|
| Fzd7-54M | Recombinant Mouse Fzd7 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
|
| Fzd7-54M-B | Recombinant Mouse Fzd7 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| FZD7-6193HF | Recombinant Full Length Human FZD7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 574 amino acids |
|
| RFL19638GF | Recombinant Full Length Chicken Frizzled-7(Fzd7) Protein, His-Tagged | E.coli | Chicken | His | Full L. Full Length of Mature Protein (32-567) |
|
| RFL20929MF | Recombinant Full Length Mouse Frizzled-7(Fzd7) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length of Mature Protein (33-572) |
|
| RFL2311HF | Recombinant Full Length Human Frizzled-7(Fzd7) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (33-574) |
|
| RFL33853XF | Recombinant Full Length Xenopus Tropicalis Frizzled-7(Fzd7) Protein, His-Tagged | E.coli | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | His | Full L. Full Length of Mature Protein (20-548) |
|
Involved Pathway
FZD7 involved in several pathways and played different roles in them. We selected most pathways FZD7 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | FGFR1,FZD8,FZD9,INHBA,ID2,PIK3CB,ID3,WNT7B,AXIN2,BMPR1A |
| Melanogenesis | ADCY2B,GNA15.1,CAMK2G1,CREB3L3L,GSK3AA,MITFB,Fzd4,CALM2,POMC,GNAIA |
| Wnt signaling pathway | MAP3K7,BAMBIA,PPP3CB,WNT11R,FZD8A,MAPK9,PRKCA,CAMK2D1,PRKACAB,FBXW11 |
| Basal cell carcinoma | HHIP,Shh,GLI1,WNT16,GLI2,FZD9,WNT10B,WNT5B,DVL2,WNT2B |
| Proteoglycans in cancer | MMP2,HSPG2,SDC1,HCLS1,PTPN11,ERBB3,WNT9B,WNT5B,NUDT16L1,PPP1R12A |
| Pathways in cancer | EGLN1,RAF1,CASP9,GLI1,LAMB3,EGLN3,AHA-1,TGFA,PRKACB,KIT |
| Hippo signaling pathway | PPP1CA,YWHAH,WWTR1,GDF6,SMAD2,ACTG1,WNT7A,MOB1A,DVL3,LATS2 |
| HTLV-I infection | TP53,PPP3CB,ITGAL,IL1R2,TGFB3,PIK3R1,VAC14,RELB,ANAPC1,CDC16 |
Protein Function
FZD7 has several biochemical functions, for example, G-protein coupled receptor activity,PDZ domain binding,Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD7 itself. We selected most functions FZD7 had, and list some proteins which have the same functions with FZD7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Wnt-protein binding | SZL,WLS,SFRP2,FZD9,LRP5L,FZD5,PTPRO,GPR177,SETD6,SFRP1A |
| frizzled binding | WNT7B,WNT7AA,WNT9A,WNT5A,FZD1,WNT3A,DVL2,WNT9B,WNT16,WNT2 |
| PDZ domain binding | LLGL2,ATP2B1A,ARHGEF16,PSEN1,DLG1,FZD3,CADM1,PARK2,PTENA,ATP2B1B |
| G-protein coupled receptor activity | TMTOPS3A,HTR1AA,OXGR1A.1,OR51B4,EDNRAB,MRGPRA7,TMTOPS2B,GRM6,RGS1,TAS2R117 |
| protein binding | RAD9A,KARS,RNPS1,MSN,ERCC3,PIAS4,KLHL41,MRAP2,RTKN,HDAC5 |
| Wnt-activated receptor activity | FZD5,LRP5,FZD3B,FZD6,FZD1,FZD3A,FZD9,LRP5L,FZD2,FZD10 |
Interacting Protein
FZD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD7.
SDCBP;WNT3;sdcbp;C1qa;UBQLN4;UBQLN1
FZD7 Related Signal Pathway
Resources
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References
- Yuan, K; Orcholski, ME; et al. Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis. AMERICAN JOURNAL OF PATHOLOGY 185:69-84(2015).
- Ross, J; Busch, J; et al. A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells. CELL REPORTS 9:1770-1780(2014).
