Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025

FZD7

  • Official Full Name

    frizzled class receptor 7

  • Overview

    Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
  • Synonyms

    FZD7; frizzled class receptor 7; FzE3; frizzled-7; fz-7; hFz7; frizzled homolog 7; frizzled family receptor 7; Frizzled, drosophila, homolog of, 7; frizzled 7, seven transmembrane spanning receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • CHO
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • GST
  • His
  • Avi
  • Flag
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FZD7-537H Active Recombinant Human FZD7 Protein, Fc-tagged CHO Fc Gln33 - Leu185
Human FZD7-384H Active Recombinant Human FZD7 Full Length Transmembrane protein(Nanodisc) HEK293 Non
Human FZD7-26288TH Recombinant Human FZD7 Wheat Germ Non 99 amino acids
Human FZD7-643H Active Recombinant Human FZD7 protein, His-tagged HEK293 His Gln33-Leu185
Human FZD7-12H Recombinant Human FZD7 protein, Fc-tagged HEK293 Fc Gln33-Leu185
Human FZD7-6088HCL Recombinant Human FZD7 293 Cell Lysate HEK293 Non
Human FZD7-5090HF Recombinant Full Length Human FZD7 Protein, GST-tagged In Vitro Cell Free System GST 574 amino acids
Human FZD7-4598H Recombinant Human FZD7 Protein, GST-tagged Wheat Germ GST
Human FZD7-1113HFL Recombinant Human FZD7 protein, His&Flag-tagged HEK293 His&Flag 1-574 aa
Human FZD7-2166H Recombinant Human FZD7 Protein, GST-tagged Wheat Germ GST
Human FZD7-6193HF Recombinant Full Length Human FZD7 Protein, GST-tagged In Vitro Cell Free System GST 574 amino acids
Human FZD7-2704H Active Recombinant Human FZD7 protein, hFc&His-tagged HEK293 His&Fc Gln33-Leu185
Human FZD7-1470H Recombinant Human FZD7 protein(Gln33-Arg254), hFc-tagged HEK293 Fc Gln33-Leu185
Human FZD7-258H Recombinant Human FZD7 Protein, Fc-tagged HEK293 Fc 574
Mouse Fzd7-589M Active Recombinant Mouse Frizzled Homolog 7 (Drosophila), Fc-tagged Mammalian cells Fc Gln33-Leu185
Mouse FZD7-6121M Recombinant Mouse FZD7 Protein Mammalian Cell His
Mouse Fzd7-54M Recombinant Mouse Fzd7 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Mouse Fzd7-54M-B Recombinant Mouse Fzd7 Protein Pre-coupled Magnetic Beads HEK293
Gallus gallus (Chicken) RFL19638GF Recombinant Full Length Chicken Frizzled-7(Fzd7) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (32-567)
Homo sapiens (Human) RFL2311HF Recombinant Full Length Human Frizzled-7(Fzd7) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-574)
Mus musculus (Mouse) RFL20929MF Recombinant Full Length Mouse Frizzled-7(Fzd7) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-572)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL33853XF Recombinant Full Length Xenopus Tropicalis Frizzled-7(Fzd7) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-548)
Chicken FZD7-5794C Recombinant Chicken FZD7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • FZD7 Related Signal Pathway

FZD7 involved in several pathways and played different roles in them. We selected most pathways FZD7 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayTCF7L2;ROCK2A;EP300;PPARD;DKK1;PORCN;FZD3;PRKACBA;WNT16
Hippo signaling pathwayTGFBR1;FRMD6;LIMD1;AXIN1;SMAD4;CCND3;AREG;ACTG1;GDF6
Signaling pathways regulating pluripotency of stem cellsMAPK13;PCGF3;LIF;SOX2;ACVR2A;ZFHX3;WNT3A;FZD2;AXIN1
MelanogenesisCALM1B;POMC;KITLG;POMCA;GNA11A;KITLGA;WNT10B;HRASB;TCF7L2
HTLV-I infectionNFKBIA;SLC2A1;WNT4;CD3E;HLA-G;RELB;SMAD3;PRKACG;HLA-DRB5
Pathways in cancerARNT2;AKT2;RASGRP3;FGF1;PML;LPAR3;DAPK2;HSP90B1;RXRB
Proteoglycans in cancerCtsl;CAV1;BRAF;MAPK13;WNT2;HCLS1;ROCK1;CAMK2A;PRKCG
Basal cell carcinomaWNT9A;Fzd4;SMO;WNT1;FZD10;APC2;FZD5;WNT7A;FZD7

FZD7 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD7 itself. We selected most functions FZD7 had, and list some proteins which have the same functions with FZD7. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityOLFR495;DRD4-RS;OPN1MW;TRHR2;GPR98;OR8B8;TAAR2;TACR3L;TAS2R117
PDZ domain bindingATP2B4;ATP2B1;GNG12;PROSAPIP1;ADRB1;LRP2;LIN7B;ACVR2A;DTNA
Wnt-activated receptor activityFZD9B;FZD5;LRP2A;FZD3;FZD3A;FZD1;FZD8;FZD2;FZD7
Wnt-protein bindingLRP5;FZD7B;PORCN;FZD3;FZD7;FZD8A;GPR177;LRP2A;FRZB
frizzled bindingWNT9A;WNT4;WNT16;WNT8B;WNT11;SFRP1;DVL2;FZD7;DVL3
protein bindingNRBP1;JDP2;PHC3;ARVCF;CD276;FIGNL1;APP;2610109H07Rik;NMU

FZD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD7.

SDCBP; WNT3; sdcbp; C1qa; UBQLN4; UBQLN1

Gene Family

GPCRs

Research Area

Related articles

Yuan, K; Orcholski, ME; et al. Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis. AMERICAN JOURNAL OF PATHOLOGY 185:69-84(2015).
Ross, J; Busch, J; et al. A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells. CELL REPORTS 9:1770-1780(2014).
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