FZD7

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FZD7

Official Full Name frizzled class receptor 7
Background Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Synonyms FZD7; frizzled class receptor 7; FzE3; frizzled-7; fz-7; hFz7; frizzled homolog 7; frizzled family receptor 7; Frizzled, drosophila, homolog of, 7; frizzled 7, seven transmembrane spanning receptor;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • CHO
    • HEK293
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FZD7-12H Recombinant Human FZD7 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human FZD7-2166H Recombinant Human FZD7 Protein, GST-tagged Wheat Germ GST
    Human FZD7-26288TH Recombinant Human FZD7 Wheat Germ N/A
    Human FZD7-4598H Recombinant Human FZD7 Protein, GST-tagged Wheat Germ GST
    Human FZD7-537H Recombinant Human FZD7 Protein, Fc-tagged CHO Fc
    Human FZD7-6088HCL Recombinant Human FZD7 293 Cell Lysate HEK293 N/A
    Human FZD7-643H Recombinant Human FZD7 protein, His-tagged HEK293 His
    Mouse Fzd7-589M Recombinant Mouse Frizzled Homolog 7 (Drosophila), Fc-tagged Mammalian cells Fc
    Mouse FZD7-6121M Recombinant Mouse FZD7 Protein Mammalian Cell His
    Chicken FZD7-5794C Recombinant Chicken FZD7 Mammalian Cell His

    FZD7 involved in several pathways and played different roles in them. We selected most pathways FZD7 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway WNT11R; PRKCBB; VANGL2; DVL1B; BAMBI; PRKACA; SOST; WNT6; LRP5; TRP53
    Hippo signaling pathway PPP2R2A; AMH; WNT6; TEAD2; TCF7; SMAD1; AREG; LEF1; AFP; WNT16
    Signaling pathways regulating pluripotency of stem cells PIK3CD; TCF3; HAND1; MAP2K2; ESRRB; PIK3R2; MEIS1; ONECUT1; HOXB1; PIK3R1
    Melanogenesis GNAI1; MAP2K2; WNT2BA; CALM3A; PRKCA; CALM3B; FZD6; DVL3A; GNAO1; PRKCBB
    HTLV-I infection ATF4; IL15RA; POLB; MSX2; ANAPC2; GPS2; BUB3; PDGFRA; RELB; WNT11
    Pathways in cancer MTOR; FGFR1; BMP2; GRB2; SMAD3; TCF7; PTK2; MMP2; RALGDS; FGF7
    Proteoglycans in cancer MAP2K1; WNT5B; WNT4; HCLS1; WNT16; PRKCA; PPP1CA; SOS1; BRAF; AKT1
    Basal cell carcinoma WNT16; WNT5A; TCF7L2; FZD5; WNT3; FZD6; WNT4; WNT11; SETD6; LEF1

    FZD7 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD7 itself. We selected most functions FZD7 had, and list some proteins which have the same functions with FZD7. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity TAS2R124; HCAR1-1; S1PR1; MRGPRA7; CXCR7B; TMTOPSA; TACR1B; OLFR147; V1RA8; OXGR1A.3
    PDZ domain binding NSF; ATP2B1B; MAP2K2; SSTR2; ACOX1; GRIA1; USHBP1; SLC9A3R1; CLCN3; SNTA1
    Wnt-activated receptor activity FZD3B; FZD1; FZD3; LRP5; FZD6; FZD3A; FZD8; FZD8A; FZD9B; FZD9
    Wnt-protein binding FZD7B; FZD9; FRZB; FZD3B; EVLA; FZD2; Fzd4; LRP2A; FZD8A; SFRP1B
    frizzled binding CTHRC1; ROR2; LRP6; WNT7AA; WNT4A; WNT2; WNT8A; WNT3; SDCBP; WNT11R
    protein binding HES1; MRPL49; UBC; MPDZ; ATP2A1; CPSF3; DAO; HCLS1; MTSS1; CTNNBL1

    FZD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD7.

    SDCBP; WNT3; sdcbp; C1qa; UBQLN4; UBQLN1

    Yuan, K; Orcholski, ME; et al. Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis. AMERICAN JOURNAL OF PATHOLOGY 185:69-84(2015).
    Ross, J; Busch, J; et al. A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells. CELL REPORTS 9:1770-1780(2014).

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