FZD7 involved in several pathways and played different roles in them. We selected most pathways FZD7 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Wnt signaling pathway |
PLCB1; CCND2; SFRP1A; PRKCB; FBXW11A; TLE3A; WNT4A; BAMBI; TBL1XR1; SFRP5 |
| Hippo signaling pathway |
LATS2; YWHAZ; WNT5B; TGFB1; PPP2R2C; AJUBA; FZD3; WNT3A; TGFB3; TEAD4 |
| Signaling pathways regulating pluripotency of stem cells |
HESX1; KLF4; WNT16; FGFR3; FZD5; ACVR2B; Fzd4; WNT1; AXIN2; WNT4 |
| Melanogenesis |
RAF1B; TYRP1; GNAI2; FZD8B; LEF1; CREB3L2; CREB3L1; GNAI2B; EP300; GNA15.4 |
| HTLV-I infection |
RELB; POLE; TGFB2; CRTC3; LTBR; TRP53; LTA; HLA-A; BAX; TGFB1 |
| Pathways in cancer |
CKS2; Flt3l; FIGF; GSK3B; PRKACG; MMP2; ARHGEF12; PTCH2; SUFU; ITGB1 |
| Proteoglycans in cancer |
VAV2; PPP1CA; FLNC; CBL; Ctsl; WNT16; FZD5; PIK3CA; SMAD2; TWIST2 |
| Basal cell carcinoma |
WNT3A; SUFU; LEF1; AXIN1; WNT5B; WNT7A; WNT8A; FZD1; APC; FZD6 |
FZD7 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD7 itself. We selected most functions FZD7 had, and list some proteins which have the same functions with FZD7. You can find most of the proteins on our site.
| Function |
Related Protein |
| G-protein coupled receptor activity |
ADRB3A; GPR34A; GPR81; TAAR9; PTGDR2; GPR62; GHSR; OR8A1; PPYR1; V2RH14 |
| PDZ domain binding |
CCDC88C; DLG4; ADAM17; KIDINS220; PSEN1; ERC1; CXXC4; GJA1; FZD2; SRR |
| Wnt-activated receptor activity |
FZD10; FZD8; LRP5; FZD5; FZD7B; FZD7; FZD1; LRP6; FZD9; LRP2A |
| Wnt-protein binding |
FZD6; GPR177; FZD8; LRP5L; FZD7; LRP5; ROR2; FZD9; LRP6; FZD2 |
| frizzled binding |
WNT7AA; WNT2B; RSPO3; DVL2; WNT10B; DVL1B; DVL3; SDCBP; FZD1; SFRP1 |
| protein binding |
CALCR; HSPE1; NONO; GTF3C3; CATSPERG2; AKAP12; ZNF502; IL5RA; FZR1; CYB5R1 |
FZD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD7.
SDCBP; WNT3; sdcbp; C1qa; UBQLN4; UBQLN1
Yuan, K; Orcholski, ME; et al. Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis. AMERICAN JOURNAL OF PATHOLOGY 185:69-84(2015).
Ross, J; Busch, J; et al. A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells. CELL REPORTS 9:1770-1780(2014).
