Recombinant Full Length Human KLK3 Protein, C-Flag-tagged

• Cat.No.: KLK3-850HFL
• Product Overview: Recombinant Full Length Human KLK3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 26.8 kDa
• AA Sequence: MWVPVVFLTLSVTWIGAAPLILSRI VGGWECEKHSQPWQVLVASRGRAVC GGVLVHPQWVLTAAHCIRNK SVILLGRHSLFHPEDTGQVFQVSHS FPHPLYDMSLLKNRFLRPGDDSSHD LMLLRLSEPAELTDAVKVMD LPTQEPALGTTCYASGWGSIEPEEF LTPKKLQCVDLHVISNDVCAQVHPQ KVTKFMLCAGRWTGGKSTCS
  GDSGGPLVCNGVLQGITSWGSEPCA LPERPSLYTKVVHYRKWIKDTIVAN PTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Pathways in cancer, Prostate cancer

Gene Information

• Gene Name: KLK3 kallikrein related peptidase 3 [ Homo sapiens (human) ]
• Official Symbol: KLK3
• Synonyms: APS; PSA; hK3; KLK2A1
• Gene ID: 354
• mRNA Refseq: NM_001648.2
• Protein Refseq: NP_001639.1
• MIM: 176820
• UniProt ID: P07288