Recombinant Human LPL, His-tagged

• Cat.No.: LPL-28596TH
• Product Overview: Recombinant full length mature Human Lipoprotein lipase with an N Terminal His tag; 458 amino acids with a predicted MWt of 51.61kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 448 amino acids
• Description: LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
• Conjugation: HIS
• Molecular Weight: 51.610kDa inclusive of tags
• Form: Lyophilised:To reconstitute, add 0.1M Acetate buffer pH4.Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at –80°C for long term storage. Reconstituted protein can be stored at 4°C for a week. In higher concentrations the
• Storage buffer: pH: 4.00Constituents:0.4% Sodium acetate, 0.3% Acetic acid
• Storage: Store at -80°C
• Sequences of amino acids: MKHHHHHHASADQRRDFIDIESKFALRTPEDTAEDTCHLI PGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVA ALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVAR FINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVN RITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSP GRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGL GDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAF EKGLCLSCRKNRCNNLGYEISKVRAKRSSKMYLKTRSQMP YKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIP FTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSW SDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGK APAVFVKCHDKSLNKKSG
• Sequence Similarities: Belongs to the AB hydrolase superfamily. Lipase family.Contains 1 PLAT domain.

Gene Information

• Gene Name: LPL lipoprotein lipase [ Homo sapiens ]
• Official Symbol: LPL
• Synonyms: LPL; lipoprotein lipase; LIPD
• Gene ID: 4023
• mRNA Refseq: NM_000237
• Protein Refseq: NP_000228
• Uniprot ID: P06858
• Chromosome Location: 8p22
• Pathway: Adipogenesis, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Chylomicron-mediated lipid transport, organism-specific biosystem; Developmental Biology, organism-specific biosystem
• Function: heparin binding; hydrolase activity; lipoprotein lipase activity; lipoprotein lipase activity; lipoprotein lipase activity