| Species : |
Human |
| Source : |
HEK293 |
| Tag : |
His |
| Protein Length : |
19-170 aa |
| Description : |
PIGF-2, as know as placenta growth factor, is a member of the VEGF sub-family that a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. It is ultimately associated with angiogenesis. Specifically, it plays a role in trophoblast growth and differentiation. Also it is a potential biomarker for preeclampsia, a condition in which blood vessels in the placenta are too narrow, resulting in high blood pressure. Under normal physiologic conditions, it is also expressed at a low level in other organs including the heart, lung, thyroid, and skeletal muscle. Recombinant human PIGF-2, fused to His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques. |
| Form : |
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol. |
| Bio-activity : |
Measured by its binding ability in a functional ELISA with Human VEGFR1/Flt-1. |
| Molecular Mass : |
18.1kDa |
| AA Sequence : |
LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRPLREKMK PERRRPKGRG KRRREKQRPT DCHLCGDAVP RR |
| Endotoxin : |
< 1 EU per 1ug of protein (determined by LAL method). |
| Purity : |
> 90% by SDS - PAGE. |
| Applications : |
SDS-PAGE, Bioactivity |
| Notes : |
For research use only. This product is not intended or approved for human, diagnostics or veterinary use. |
| Storage : |
Can be stored at 2 centigrade to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles. |
| Concentration : |
0.5mg/ml (determined by Absorbance at 280nm). |
| References : |
Asma Khalil., et al, (2008) PLoS One. 3:e2766.
Khurana R., et al, (2005) Circulation. 111:2828-2836. |
