| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
DDK |
| Form : |
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. |
| Molecular Mass : |
103 kDa |
| AA Sequence : |
A DNA sequence from TrueORF clone, RC220230, encoding human full-length PTPRN. |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Protein Families : |
Druggable Genome, Transmembrane |
| Protein Pathways : |
Type I diabetes mellitus |
