Recombinant Full Length Human PTPRN Protein, C-DDK-tagged

• Cat.No.: PTPRN-74HFL
• Product Overview: Recombinant Full Length Human PTPRN Protein, fused to DDK-tag at C-terminus, was expressed in Sf9.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Flag
• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
• Form: 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.
• Molecular Mass: 103 kDa
• AA Sequence: A DNA sequence from TrueORF clone, RC220230, encoding human full-length PTPRN.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Type I diabetes mellitus
• Full Length: Full L.

Gene Information

• Gene Name: PTPRN protein tyrosine phosphatase receptor type N [ Homo sapiens (human) ]
• Official Symbol: PTPRN
• Synonyms: IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
• Gene ID: 5798
• mRNA Refseq: NM_002846.4
• Protein Refseq: NP_002837.1
• MIM: 601773
• UniProt ID: Q16849