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Recombinant HCMV Glycoprotein B (GB) protein, Fc-tagged

Cat.No. : GB-355H
Product Overview : Recombinant HCMV Glycoprotein B (GB) protein (Val23-Lys700), fused to human IgG1 Fc tag (rh CMV-GB Fc Chimera) with furin cleavage site mutated from 'RTKR' to 'TTQT', was produced in human 293 cells (HEK293).
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  • Gene Information
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Description : Human cytomegalovirus is a species of the Cytomegalovirus genus of viruses, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is typically abbreviated as HCMV or, commonly but more ambiguously, as CMV. CMV Virus Envelope Glycoportein B (CMV-GB) can be cleaved into glycoprotein GP55. Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. CMV-GB may be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Furthermore, CMV-GB can interact with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also, CMV-GB participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
Source : HEK293
Species : HCMV
Tag : human IgG1 Fc
Form : Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 104 kDa. The protein migrates as 140-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 678
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >85% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : UL55
Official Symbol : GB
Synonyms : HHV5wtgp060
Gene ID : 3077424
Protein Refseq : YP_081514.1
UniProt ID : P13201

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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