Recombinant Human ACMSD Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human ACMSD Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : ACMSD-1720H
Product Overview : ACMSD MS Standard C13 and N15-labeled recombinant protein (NP_612199) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 38 kDa
AA Sequence : MKIDIHSHIL PKEWPDLKKR FGYGGWVQLQ HHSKGEAKLL KDGKVFRVVR ENCWDPEVRI REMDQKGVTV QALSTVPVMF SYWAKPEDTL NLCQLLNNDL ASTVVSYPRR FVGLGTLPMQ APELAVKEME RCVKELGFPG VQIGTHVNEW DLNAQELFPV YAAAERLKCS LFVHPWDMQM DGRMAKYWLP WLVGMPAETT IAICSMIMGG VFEKFPKLKV CFAHGGGAFP FTVGRISHGF SMRPDLCAQD NPMNPKKYLG SFYTDALVHD PLSLKLLTDV IGKDKVILGT DYPFPLGELE PGKLIESMEE FDEETKNKLK AGNALAFLGL ERKQFETRTR PLEQKLISEE DLAANDILDY KDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : ACMSD aminocarboxymuconate semialdehyde decarboxylase [ Homo sapiens (human) ]
Official Symbol : ACMSD
Synonyms : ACMSD; aminocarboxymuconate semialdehyde decarboxylase; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase;
Gene ID : 130013
mRNA Refseq : NM_138326
Protein Refseq : NP_612199
MIM : 608889
UniProt ID : Q8TDX5

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