Species : |
Human |
Source : |
HEK293 |
Tag : |
Flag |
Protein Length : |
1-513aa |
Description : |
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. |
Molecular Mass : |
57.85 kDa |
Usage : |
1 vial of 100 μg gene specific transient over-expression cell lysate in RIPA buffer 1 vial of 100 μg empty vector transfected control cell lysate in RIPA buffer 1 vial of 250 μL 2×SDS Sample Buffer (4% SDS, 125mM Tris-HCl pH6.8, 10% Glycerol, 0.002% Bromphenol blue, 100mM DTT) |
Stability : |
Lysate samples are stable for 12 months from the date of receipt when stored at -80 centigrade. |
Storage : |
Upon receiving, store the sample at -80 centigrade. Also after dilution, the protein sample should be aliquoted and stored at -80 centigrade for long term storage. Avoid repeated freeze-thaw cycles. |
Dilutions : |
Lysate samples can be diluted with 2×SDS Sample Buffer provided. |
Shipping : |
The lysate is shipped with dry ice. |