ACVR2A

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ACVR2A

Official Full Name activin receptor IIA
Background Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Synonyms ACTRII; ACVR2; activin receptor IIA; ACVR2A
    • Species :
    • Bovine
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ACVR2A-1585H Recombinant Human Activin A Receptor, Type IIA Sf21 Insect Cell N/A
    Human ACVR2A-195H Recombinant Human ACVR2A protein, Fc-tagged HEK293 Fc
    Human ACVR2A-254H Recombinant Human ACVR2A Protein, GST-tagged Insect Cell GST
    Human ACVR2A-255H Recombinant Human ACVR2A Protein, GST-tagged Wheat Germ GST
    Human ACVR2A-26487TH Recombinant Human ACVR2A Wheat Germ N/A
    Human ACVR2A-292H Recombinant Human ACVR2A Protein, His/GST-tagged E.coli His/GST
    Human ACVR2A-3096HCL Recombinant Human ACVR2A cell lysate Human Cell N/A
    Human ACVR2A-3097HCL Recombinant Human ACVR2A cell lysate, Myc/DDK tag HEK293T Myc/DDK
    Human ACVR2A-3819H Recombinant Human ACVR2A, His tagged Human Cell His
    Human ACVR2A-510H Recombinant Human ACVR2A Protein, GST-tag Insect Cell GST
    Human ACVR2A-532H Recombinant Human ACVR2A, Fc-tagged, Biotinylated Human Cell Fc
    Human ACVR2A-6994H Recombinant Human ACVR2A, His-tagged Sf9 Insect Cell His
    Human ACVR2A-8314H Recombinant Human ACVR2A Sf21 Insect Cell N/A
    Human ACVR2A-883H Recombinant Human ACVR2A Protein, His-tagged HEK293 His
    Human ACVR2A-884H Recombinant Human ACVR2A Protein, Fc/His-tagged HEK293 Fc/His
    Human ACVR2A-P015H Recombinant Human ActRIIA therapeutic protein, Fc-tagged Fc
    Mouse ACVR2A-2280MCL Recombinant Mouse ACVR2A cell lysate Human Cell N/A
    Mouse Acvr2a-293M Recombinant Mouse Acvr2a Protein, His-tagged E.coli His
    Mouse Acvr2a-492M Recombinant Mouse Acvr2a, His tagged Human Cell His
    Mouse Acvr2a-493M Recombinant Mouse Acvr2a, Fc-His tagged Human Cell Fc/His
    Rat ACVR2A-494R Recombinant Rat ACVR2A Protein Mammalian Cell His
    Bovine ACVR2A-290B Recombinant Bovine ACVR2A Protein, His-tagged E.coli His
    Chicken ACVR2A-6919C Recombinant Chicken ACVR2A Mammalian Cell His

    ACVR2A involved in several pathways and played different roles in them. We selected most pathways ACVR2A participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IFNGR2; Fasl; CSF1R; IL11RA; BMPR1BA; PDGFA; GH2; LTBR; CCL3; CCL1
    TGF-beta signaling pathway ID1; BMP8B; AMHR2; CHD; RPS6KB1B; SPAW; ROCK1; ID2B; INHBAB; LFT2
    Signaling pathways regulating pluripotency of stem cells FGFR2; MAP2K1; FZD3; MAPK12; APC; FZD5; MAPK3; GRB2; FZD2; HOXB1

    ACVR2A has several biochemical functions, for example, ATP binding, PDZ domain binding, contributes_to activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR2A itself. We selected most functions ACVR2A had, and list some proteins which have the same functions with ACVR2A. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding IGF1R; FGFR3; SGK3; HARS2; CMPK1; ABCA4A; MYO18A; CAMK1DB; ATM; TXK
    PDZ domain binding SLC9A3R2; ERC1; GRIK2; CLCN3; ACCN3; DLC; NKD1; SLC26A6; SLC22A5; BAIAP2
    contributes_to activin binding ACVR2A; ACVR1B
    contributes_to activin-activated receptor activity ACVR1B; ACVR2A
    coreceptor activity PVRL2; CCR5; TGFBR3; HFE2; CCR8; ACVR2A; CXCR7; CXCR6; CD86; ZP2
    growth factor binding RHBDF1; A2M; GHR; LTBP2; ERBB3; SDCBP; FLT4; HTRA1B; FLT1; OSMR
    inhibin binding ACVR2A; ACVR1B; INHA; IGSF1; INHBA
    metal ion binding POLR3A; FTR67; ZNF37A; OSGEPL1; ZNF621; ZNF695; ZNF644A; LNPA; Car12; ZNF433
    protein binding ANTXR2; ENTPD3; PCBP1; FIBPB; FAM195A; NFATC3; FRK; SLC6A18; TRIM32; EPHB6
    contributes_to protein binding MSH2; MEF2A; MLH1; POLR2A; INHA; MSH6; TAF10; CRY1A; TGFBR3; PAK1
    protein self-association ZFP639; SLC9A3R1; CNTN2; CCDC88C; ZSWIM2; ZKSCAN17; BCL10; PROSAPIP1; EPB49; TTN
    protein serine/threonine kinase activity PIM1; HIPK2; SGK2A; STK35; NLK1; MAST4; PRKCQ; MAPK8A; MAPK12A; SGK2
    receptor signaling protein serine/threonine kinase activity STK25A; STK26; BMPR1AB; PAK2B; ACVR1BA; STK24B; BMPR2A; ACVR1L; PANK1A; STK25B
    transmembrane receptor protein serine/threonine kinase activity TGFBR2; BMPR2A; ACVR1BA; BMPR1A; BMPR1BB; BMPR1AA; ACVR1B; ACVR1; TGFBR1B; ACVR2A

    ACVR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR2A.

    Magi2; DAXX; linkable pd173955 analogue

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