acvr2a
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  • Official Full Name
  • activin receptor IIA
  • Background
  • Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
  • Synonyms
  • ACTRII; ACVR2; activin receptor IIA; ACVR2A
Cat.#:ACVR2A-26487THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ACVR2A
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Cat.#:ACVR2A-292HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACVR2A Protein, His/GST-tagged
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Cat.#:Acvr2a-293MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Acvr2a Protein, His-tagged
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Cat.#:ACVR2A-290BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine ACVR2A Protein, His-tagged
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Cat.#:ACVR2A-195HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR2A protein, Fc-tagged
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Cat.#:ACVR2A-254HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ACVR2A Protein, GST-tagged
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Cat.#:ACVR2A-255HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACVR2A Protein, GST-tagged
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Cat.#:ACVR2A-3819HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR2A, His tagged
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Cat.#:ACVR2A-532HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ACVR2A, Fc-tagged, Biotinylated
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Cat.#:ACVR2A-6994HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ACVR2A, His-tagged
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Cat.#:ACVR2A-8314HTag:
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human ACVR2A
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Cat.#:ACVR2A-883HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ACVR2A Protein, His-tagged
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Cat.#:ACVR2A-884HTag:Fc/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ACVR2A Protein, Fc/His-tagged
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Cat.#:ACVR2A-P015HTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human ActRIIA therapeutic protein, Fc-tagged
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Cat.#:Acvr2a-492MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Acvr2a, His tagged
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Cat.#:Acvr2a-493MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Acvr2a, Fc-His tagged
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Cat.#:ACVR2A-494RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACVR2A Protein
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Cat.#:ACVR2A-6919CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACVR2A
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Cat.#:ACVR2A-1585HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type IIA
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Cat.#:ACVR2A-3096HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR2A cell lysate
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Cat.#:ACVR2A-2280MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ACVR2A cell lysate
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Involved Pathway

ACVR2A involved in several pathways and played different roles in them. We selected most pathways ACVR2A participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL22RA2; IL19; GM2002; IL-8; ACKR3B; Ccl9; TNFSF18; MPL; IL5RA; ACVR1B
TGF-beta signaling pathway
SMAD1; TGFB2; SMAD4; MAPK1; BMP7; SMURF1; SMAD7B; SMAD6; NOG2; SP1
Signaling pathways regulating pluripotency of stem cells
WNT3; ESRRB; WNT6; WNT3A; ACVR2A; WNT5A; BMI1; PAX6; SMAD3; GRB2

Protein Function

ACVR2A has several biochemical functions, for example, ATP binding, PDZ domain binding, contributes_to activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR2A itself. We selected most functions ACVR2A had, and list some proteins which have the same functions with ACVR2A. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MARK1; EIF2AK4; KIF11; CDKL2; OLA1; KIF23; ROCK2A; PRKG2; UBA1; ABCG2A
Function PDZ domain binding
Related Protein CXXC4; KIDINS220B; PDZK1; ADRB1; SDC2; FZD8; GJA1; CFTR; KIDINS220; ARHGEF16
Function contributes_to activin binding
Related Protein ACVR1B; ACVR2A
Function contributes_to activin-activated receptor activity
Related Protein ACVR2A; ACVR1B
Function coreceptor activity
Related Protein NRP1; TGFBR3; CXCR4; ZP2; CXCR7; ACVR2A; RGMD; CD86; IGSF1; CD8A
Function growth factor binding
Related Protein HTRA1B; GHRHR; FGFBP2; HTRA1A; NRP2; NRP1; RPL37; LTBP2; KDR; BMPR2
Function inhibin binding
Related Protein ACVR1B; INHBA; IGSF1; INHA; ACVR2A
Function metal ion binding
Related Protein TRIM26; SMAD9; WT1B; NENF; ZFP629; TERT; GNS; TRAF4B; CYP2Y3; MUT
Function protein binding
Related Protein PLIN3; CUL4A; DNAJA4; SLAMF1; PRKX; PRKACB; SLX4; MAPRE3; INCA1; C1S
Function contributes_to protein binding
Related Protein ACVR2A; CRY1A; CPSF3L; MEF2A; MSH2; TAF10; INHA; MLH1; MSH6; TGFBR3
Function protein self-association
Related Protein TTN; TP53; EPB49; DYRK1A; RYR2; AGTR1A; ZNF496; TRIM32; L1CAM; BCL10
Function protein serine/threonine kinase activity
Related Protein PRKCA; TSSK1; SNRK; PSKH1; ROCK1; PRKACBB; STK24; MAP3K13; LRRK1; MKNK2
Function receptor signaling protein serine/threonine kinase activity
Related Protein BMPR1BB; ACVRL1; PAK2A; STK25A; ALPK2; ACVR2AA; PANK1A; BMPR1BA; ACVR1C; BMPR2A
Function transmembrane receptor protein serine/threonine kinase activity
Related Protein ACVR1B; BMPR1AB; BMPR1A; ACVR2A; BMPR1BA; BMPR2A; BMPR1AA; ALPK2; ACVR2AA; BMPR2B

Interacting Protein

ACVR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR2A.
Magi2; DAXX; linkable pd173955 analogue