Active Recombinant Human ACVR2A Homodimer Protein, His tagged

• Cat.No.: ACVR2A-16H
• Product Overview: ACVR2A protein dimer contains an ACVR2A extracellular domain (UniProt# P27037) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: His
• Protein Length: 20-135 aa
• Description: Human Activin receptor type-2A (ACVR2A) is a Type I transmembrane protein belonging to the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins. ACVR2A contains an extracellular domain composed of a ligand binding domain. It is a Type II serine/threonine kinase receptor and functions by binding ligands like activins, myostatin, and other TGF-β family members and forming receptor complexes activating the intracellular signaling pathway. ACVR2A interacts with inhibin beta A (INHBA) as well as myostatin, although to a lesser extent than ACVR2B. ACVR2A can form homodimers (ACVR2A–ACVR2A) or heterodimers (e.g., with ACVR2B). ACVR2A dimers are involved in regulating important biological processes such as cell growth, differentiation, development, and inflammation. Homodimerization, in particular, plays a pivotal role in the activin signaling pathway, which influences processes like tissue repair, muscle growth, and immune responses. Mutation or decreased expression of ACVR2A has been shown to play an important role in several cancers including prostate and colorectal. Therefore, a recombinant protein mimicking the ACVR2A dimer conformation can be crucial for basic and translational research as well as ACVR2A-targeting therapeutic discovery.
• Molecular Mass: 43 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for ACVR2A-specific antibody binding assays. Suggested Applications: SPR & BLI for ACVR2A-specific antibody protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: ACVR2A activin A receptor, type IIA [ Homo sapiens (human) ]
• Official Symbol: ACVR2A
• Synonyms: ACVR2A; activin A receptor, type IIA; activin A receptor, type II, ACVR2; activin receptor type-2A; ACTRII; ACVR2
• Gene ID: 92
• mRNA Refseq: NM_001616
• Protein Refseq: NP_001607
• MIM: 102581
• UniProt ID: P27037