Recombinant Human ACVR2B Protein, Fc\His-tagged

• Cat.No.: ACVR2B-171H
• Product Overview: Recombinant Human Activin Receptor IIB is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc, 6His tag at the C-terminus.

Specification

• Description: Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.
• Source: Human Cells
• Species: Human
• Tag: Fc\His
• Form: Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.4.
• AA Sequence: Ser19-Thr134
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Shipping: Ambient

Gene Information

• Gene Name: ACVR2B activin A receptor type 2B [ Homo sapiens (human) ]
• Official Symbol: ACVR2B
• Synonyms: Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; HTX4; ACTRIIB; ActR-IIB
• Gene ID: 93
• mRNA Refseq: NM_001106.4
• Protein Refseq: NP_001097.2
• MIM: 602730
• UniProt ID: Q13705