Recombinant Full Length Human ACVR2B Protein, C-Flag-tagged
Cat.No. : | ACVR2B-1503HFL |
Product Overview : | Recombinant Full Length Human ACVR2B Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 57.5 kDa |
AA Sequence : | MTAPWVALALLWGSLCAGSGRGEAE TRECIYYNANWELERTNQSGLERCE GEQDKRLHCYASWRNSSGTI ELVKKGCWLDDFNCYDRQECVATEE NPQVYFCCCEGNFCNERFTHLPEAG GPEVTYEPPPTAPTLLTVLA YSLLPIGGLSLIVLLAFWMYRHRKP PYGHVDIHEDPGPPPPSPLVGLKPL QLLEIKARGRFGCVWKAQLM NDFVAVKIFPLQDKQSWQSEREIFS TPGMKHENLLQFIAAEKRGSNLEVE LWLITAFHDKGSLTDYLKGN IITWNELCHVAETMSRGLSYLHEDV PWCRGEGHKPSIAHRDFKSKNVLLK SDLTAVLADFGLAVRFEPGK PPGDTHGQVGTRRYMAPEVLEGAIN FQRDAFLRIDMYAMGLVLWELVSRC KAADGPVDEYMLPFEEEIGQ HPSLEELQEVVVHKKMRPTIKDHWL KHPGLAQLCVTIEECWDHDAEARLS AGCVEERVSLIRRSVNGTTS DCLVSLVTSVTNVDLPPKESSITRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Protein Kinase, Transmembrane |
Protein Pathways : | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway |
Gene Name : | ACVR2B activin A receptor type 2B [ Homo sapiens (human) ] |
Official Symbol : | ACVR2B |
Synonyms : | HTX4; ACTRIIB; ActR-IIB |
Gene ID : | 93 |
mRNA Refseq : | NM_001106.4 |
Protein Refseq : | NP_001097.2 |
MIM : | 602730 |
UniProt ID : | Q13705 |
Products Types
◆ Recombinant Protein | ||
ACVR2B-084H | Recombinant Human ACVR2B Protein, His-tagged | +Inquiry |
ACVR2B-275H | Recombinant Human ACVR2B Protein, His (Fc)-Avi-tagged | +Inquiry |
ACVR2B-02H | Recombinant Active Human ACVR2B Protein, GST-tagged | +Inquiry |
ACVR2B-011M | Active Recombinant Mouse ACVR2B Protein, Fc-tagged | +Inquiry |
ACVR2B-198M | Active Recombinant Mouse ACVR2B protein(Met1-Thr134), His&hFc-tagged | +Inquiry |
◆ Lysates | ||
ACVR2B-734CCL | Recombinant Cynomolgus ACVR2B cell lysate | +Inquiry |
ACVR2B-2540MCL | Recombinant Mouse ACVR2B cell lysate | +Inquiry |
ACVR2B-2724HCL | Recombinant Human ACVR2B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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