ACVR2B

  • Official Full Name

    activin A receptor, type IIB

  • Overview

    Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
  • Synonyms

    ACVR2B; activin A receptor, type IIB; ACTRIIB; ActR-IIB; HTX4;

  • Recombinant Proteins
  • Therapeutic Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Xenopus laevis (African clawed frog)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • His
  • hFc
  • Fc\His
  • Fc|His
  • Flag
  • GST
  • HIgG1|His
  • His (Fc)
  • Avi
  • B2M
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACVR2B-533H Active Recombinant Human ACVR2B, Fc-tagged, Biotinylated Human Cell Fc
Human ACVR2B-257H Active Recombinant Human ACVR2B Protein, GST-tagged Insect Cell GST
Human ACVR2B-P014H Recombinant Human ACVR2B, Fc-tagged therapeutic protein Fc
Human ACVR2B-196H Recombinant Human ACVR2B, Fc tagged Human Cell Fc
Human ACVR2B-498H Recombinant Human ACVR2B protein, HIgG1/His-tagged Mammalian cells HIgG1/His
Human ACVR2B-499H Recombinant Human ACVR2B protein, HIgG1/His-tagged Insect Cell HIgG1/His
Human ACVR2B-1586H Recombinant Human Activin A Receptor, Type IIB Sf21 Insect Cell N/A
Human ACVR2B-6995H Recombinant Human ACVR2B, GST-tagged Sf9 Insect Cell GST 182-488 aa
Human ACVR2B-938H Recombinant Human Activin A Receptor, Type IIB, His-tagged HEK293 His
Human ACVR2B-197H Recombinant Human ACVR2B, His tagged Human Cell His
Human ACVR2B-29H Recombinant Human ACVR2B protein, Flag-tagged, Biotinylated Insect Cell Flag
Human ACVR2B-258H Recombinant Human ACVR2B Protein, GST-tagged Wheat Germ GST
Human ACVR2B-198H Recombinant Human Activin ACVR2B protein, His-tagged HEK293 His 119
Human ACVR2B-886H Recombinant Human ACVR2B Protein, His-tagged HEK293 His
Human ACVR2B-885H Recombinant Human ACVR2B Protein, Fc/His-tagged HEK293 Fc/His
Human ACVR2B-2724HCL Recombinant Human ACVR2B cell lysate Human Cell N/A
Human ACVR2B-1155H Recombinant Human ACVR2B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ACVR2B-4440H Recombinant Human ACVR2B protein, His-B2M-tagged E.coli His-B2M 19-137aa
Human ACVR2B-3284H Recombinant Human ACVR2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACVR2B-02H Recombinant Active Human ACVR2B Protein, GST-tagged Insect Cell GST 182-488
Human ACVR2B-1503HFL Recombinant Full Length Human ACVR2B Protein, C-Flag-tagged Mammalian cells Flag
Human ACVR2B-5762H Recombinant Human ACVR2B protein, His-tagged Yeast His 19-137aa
Human ACVR2B-833HF Recombinant Full Length Human ACVR2B Protein, GST-tagged In Vitro Cell Free System GST 303 amino acids
Human ACVR2B-2675H Active Recombinant Human ACVR2B protein, hFc&His-tagged HEK293 hFc&His Ser19-Thr134
Human ACVR2B-171H Recombinant Human ACVR2B Protein, Fc\His-tagged Human Cell Fc\His
Human ACVR2B-0490H Recombinant Human ACVR2B Protein (Met1-Leu135), C-Fc-tagged Mammalian cells C-Fc Met1-Leu135
Human ACVR2B-275H Recombinant Human ACVR2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ACVR2B-084H Recombinant Human ACVR2B Protein, His-tagged HEK293 His 512
Human ACVR2B-275H-B Recombinant Human ACVR2B Protein Pre-coupled Magnetic Beads HEK293
Human ACVR2B-0491H Recombinant Human ACVR2B Protein (Ser19-Thr134), C-His-tagged Mammalian cells C-His Ser19-Thr134
Human ACVR2B-5314H Recombinant Human ACVR2B Protein (Met1-Thr134), C-Fc tagged Mammalian cells C-Fc Met1-Thr134
Mouse ACVR2B-198M Active Recombinant Mouse ACVR2B protein(Met1-Thr134), His&hFc-tagged HEK293 C-His&hFc Met1-Thr134
Mouse Acvr2b-424M Active Recombinant Mouse Acvr2b protein, His-tagged HEK293 His Met1-Thr134
Mouse ACVR2B-2540MCL Recombinant Mouse ACVR2B cell lysate Human Cell N/A
Mouse ACVR2B-011M Active Recombinant Mouse ACVR2B Protein, Fc-tagged HEK293 Fc Met 1-Thr 134
Mouse Acvr2b-529M Recombinant Mouse Acvr2b Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Acvr2b-295M Recombinant Mouse Acvr2b Protein, His-tagged E.coli His Leu214~Asn350
Rat ACVR2B-495R Recombinant Rat ACVR2B Protein Mammalian Cell His
Rat ACVR2B-151R-B Recombinant Rat ACVR2B Protein Pre-coupled Magnetic Beads HEK293
Rat ACVR2B-151R Recombinant Rat ACVR2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Acvr2b-296R Recombinant Rat Acvr2b Protein, His-tagged E.coli His Gly342~Ile482
Cynomolgus ACVR2B-3386C Active Recombinant Cynomolgus ACVR2B protein(Ser28-Thr143), His-tagged HEK293 C-His Ser28-Thr143
Cynomolgus ACVR2B-2182C Active Recombinant Cynomolgus ACVR2B protein, hFc-tagged HEK293 hFc Ser28-Thr143
Cynomolgus Monkey ACVR2B-193C Active Recombinant Cynomolgus ACVR2B Human Cell N/A Ser28-Thr143
Cynomolgus Monkey ACVR2B-63C Recombinant Cynomolgus ACVR2B, Fc tagged Human Cell Fc/His
Cynomolgus Monkey ACVR2B-64C Recombinant Cynomolgus ACVR2B, His tagged Human Cell Fc/His
Cynomolgus Monkey ACVR2B-734CCL Recombinant Cynomolgus ACVR2B cell lysate Human Cell N/A
Mus musculus (Mouse) RFL-25539MF Recombinant Full Length Mouse Activin Receptor Type-2B(Acvr2B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-536)
Rattus norvegicus (Rat) RFL-28277RF Recombinant Full Length Rat Activin Receptor Type-2B(Acvr2B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-513)
Xenopus laevis (African clawed frog) RFL-33848XF Recombinant Full Length Xenopus Laevis Activin Receptor Type-2B(Acvr2B) Protein, His-Tagged E.coli expression system His Full Length (21-511)
Zebrafish ACVR2B-8811Z Recombinant Zebrafish ACVR2B Mammalian Cell His
Chicken ACVR2B-5890C Recombinant Chicken ACVR2B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACVR2B Related Research Area

ACVR2B involved in several pathways and played different roles in them. We selected most pathways ACVR2B participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNF;IL24;PF4;FLT3LG;CD70;CCL21;PLEKHO2;TNFSF9;CXCL10
TGF-beta signaling pathwayBMP5;PPP2R1A;GDF5;PITX2;TGFB2;THBS1;SMAD3A;BMP8A;SP1
Signaling pathways regulating pluripotency of stem cellsWNT4;PCGF5;Fzd4;ACVR2B;FZD6;PCGF2;FZD9;BMP2;INHBE

ACVR2B has several biochemical functions, for example, ATP binding, activin binding, contributes_to activin receptor activity, type II. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR2B itself. We selected most functions ACVR2B had, and list some proteins which have the same functions with ACVR2B. You can find most of the proteins on our site.

Function Related Protein
ATP bindingORC4L;KIF3CB;ABCA8;ATP6V1A;CAMK1G;GLUD1;DDX28;BBS12;ATAD5B
activin bindingSMURF1;ACVR1;FKBP1A;ACVRL1;FSTL3;TGFBR3;SMAD7;FST;ACVR2B
contributes_to activin receptor activity, type II
growth factor bindingIGFBP2A;OSMR;RHBDF1;HTRA1A;IL6ST;NRP2;LTBP2;NKD2;FLT4
metal ion bindingZNF576.2;PCK2;ATP13A;PGM2L1;CYP4V7;B3GNT1;SMYD3;FOLH1;SIVA1
protein bindingMVK;LHX9;PCSK5;CDCA7L;ABCG2;CLN6;NCK2;LY6H;MRPL11
protein serine/threonine kinase activityIKBKB;RIPK2;LMTK2;ADCK5;DSTYK;PDK3;MAP4K2;PDIK1L;DYRK1B
protein serine/threonine/tyrosine kinase activityAURKB;DYRK2;DSTYK;RPS6KB1;TESK2;DYRK1A;CLK4;RPS6KA2;AURKC
receptor signaling protein serine/threonine kinase activityTGFB2;BMPR1AB;BMPR1BA;ACVR1C;ALPK2;OXSR1B;BMPR2;ACVR2A;STK26

ACVR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR2B.

MSTN; Mstn; GDF11; FSTL1; INHBA; HSP90AB1; linkable pd173955 analogue; bosutinib; dasatinib

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