| Description : |
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
83.2 kDa |
| AA Sequence : |
MRLLRRWAFAALLLSLLPTPGLGTQ GPAGALRWGGLPQLGGPGAPEVTEP SRLVRESSGGEVRKQQLDTRVRQEP PGGPPVHLAQVSFVIPAFNSNFTLD LELNHHLLSSQYVERHFSREGTTQH STGAGDHCYYQGKLRGNPHSFAALS TCQGLHGVFSDGNLTYIVEPQEVAG PWGAPQGPLPHLIYRTPLLPDPLGC REPGCLFAVPAQSAPPNRPRLRRKR QVRRGHPTVHSETKYVELIVINDHQ LFEQMRQSVVLTSNFAKSVVNLADV IYKEQLNTRIVLVAMETWADGDKIQ VQDDLLETLARLMVYRREGLPEPSD ATHLFSGRTFQSTSSGAAYVGGICS LSHGGGVNEYGNMGAMAVTLAQTLG QNLGMMWNKHRSSAGDCKCPDIWLG CIMEDTGFYLPRKFSRCSIDEYNQF LQEGGGSCLFNKPLKLLDPPECGNG FVEAGEECDCGSVQECSRAGGNCCK KCTLTHDAMCSDGLCCRRCKYEPRG VSCREAVNECDIAETCTGDSSQCPP NLHKLDGYYCDHEQGRCYGGRCKTR DRQCQVLWGHAAADRFCYEKLNVEG TERGSCGRKGSGWVQCSKQDVLCGF LLCVNISGAPRLGDLVGDISSVTFY HQGKELDCRGGHVQLADGSDLSYVE DGTACGPNMLCLDHRCLPASAFNFS TCPGSGERRICSHHGVCSNEGKCIC QPDWTGKDCSIHNPLPTSPPTGETE RYKGPSGTNIIIGSIAGAVLVAAIV LGGTGWGFKNIRRGRSGGATRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
