Recombinant Full Length Human ADAM11 Protein, C-Flag-tagged

• Cat.No.: ADAM11-734HFL
• Product Overview: Recombinant Full Length Human ADAM11 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 83.2 kDa
• AA Sequence: MRLLRRWAFAALLLSLLPTPGLGTQ GPAGALRWGGLPQLGGPGAPEVTEP SRLVRESSGGEVRKQQLDTR VRQEPPGGPPVHLAQVSFVIPAFNS NFTLDLELNHHLLSSQYVERHFSRE GTTQHSTGAGDHCYYQGKLR GNPHSFAALSTCQGLHGVFSDGNLT YIVEPQEVAGPWGAPQGPLPHLIYR TPLLPDPLGCREPGCLFAVP AQSAPPNRPRLRRKRQVRRGHPTVH SETKYVELIVINDHQLFEQMRQSVV LTSNFAKSVVNLADVIYKEQ LNTRIVLVAMETWADGDKIQVQDDL LETLARLMVYRREGLPEPSDATHLF SGRTFQSTSSGAAYVGGICS LSHGGGVNEYGNMGAMAVTLAQTLG QNLGMMWNKHRSSAGDCKCPDIWLG CIMEDTGFYLPRKFSRCSID EYNQFLQEGGGSCLFNKPLKLLDPP ECGNGFVEAGEECDCGSVQECSRAG GNCCKKCTLTHDAMCSDGLC CRRCKYEPRGVSCREAVNECDIAET CTGDSSQCPPNLHKLDGYYCDHEQG RCYGGRCKTRDRQCQVLWGH AAADRFCYEKLNVEGTERGSCGRKG SGWVQCSKQDVLCGFLLCVNISGAP RLGDLVGDISSVTFYHQGKE LDCRGGHVQLADGSDLSYVEDGTAC GPNMLCLDHRCLPASAFNFSTCPGS GERRICSHHGVCSNEGKCIC QPDWTGKDCSIHNPLPTSPPTGETE RYKGPSGTNIIIGSIAGAVLVAAIV LGGTGWGFKNIRRGRSGGATRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane

Gene Information

• Gene Name: ADAM11 ADAM metallopeptidase domain 11 [ Homo sapiens (human) ]
• Official Symbol: ADAM11
• Synonyms: MDC
• Gene ID: 4185
• mRNA Refseq: NM_002390.6
• Protein Refseq: NP_002381.2
• MIM: 155120
• UniProt ID: O75078