Recombinant Human AKT1S1 Protein, GST-tagged
Cat.No. : | AKT1S1-423H |
Product Overview : | Human AKT1S1 full-length ORF ( AAH16043.1, 1 a.a. - 256 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 53.8 kDa |
AA Sequence : | MASGRPEELWEAVVGAAERFRARTG TELVLLTAAPPPPPRPGPCAYAAHG RGALAEAARRCLHDIALAHRAATAA RPPAPPPAPQPPSPTPSPPRPTLAR EDNEEDEDEPTETETSGEQLGISDN GGLFVMDEDATLQDLPPFCESDPES TDDGSLSEETPAGPPTCSVPPASAL PTQQYAKSLPVSVPVWGFKEKRTEA RSSDEENGPPSSPDLDRIAASMRAL VLREAEDTQVFGDLPRPRLNTSDFQ KLKRKY |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AKT1S1 AKT1 substrate 1 (proline-rich) [ Homo sapiens ] |
Official Symbol : | AKT1S1 |
Synonyms : | AKT1S1; AKT1 substrate 1 (proline-rich); proline-rich AKT1 substrate 1; Lobe; MGC2865; PRAS40; proline rich Akt substrate; 40 kDa; 40 kDa proline-rich AKT substrate; proline-rich Akt substrate, 40 kDa; |
Gene ID : | 84335 |
mRNA Refseq : | NM_001098632 |
Protein Refseq : | NP_001092102 |
MIM : | 610221 |
UniProt ID : | Q96B36 |
Products Types
◆ Recombinant Protein | ||
Akt1s1-1585M | Recombinant Mouse Akt1s1 Protein, Myc/DDK-tagged | +Inquiry |
AKT1S1-444M | Recombinant Mouse AKT1S1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AKT1S1-26H | Recombinant Human AKT1S1 protein, MYC/DDK-tagged | +Inquiry |
AKT1S1-1934H | Recombinant Human AKT1S1, GST-tagged | +Inquiry |
AKT1S1-27H | Recombinant Human AKT1S1 protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
AKT1S1-15HCL | Recombinant Human AKT1S1 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (11)
Ask a questionMutations in AKT1S1 have been identified in specific types of cancer, particularly endometrial cancer. These mutations can lead to alterations in AKT1S1 function, affecting its interaction with AKT1 and modulating downstream signaling pathways. However, further studies are needed to fully understand the extent and significance of AKT1S1 mutations in disease development and progression.
AKT1S1 protein regulates various cellular processes, including cell growth, proliferation, survival, protein synthesis, and autophagy. By modulating the activity of AKT1, AKT1S1 influences downstream signaling pathways involved in these processes.
Currently, there are no specific known inhibitors or activators of AKT1S1 that have been developed or approved for therapeutic use. Since AKT1S1 interacts with AKT1 and acts as an endogenous regulator of its activity, modulating AKT1S1 function indirectly affects AKT1 signaling.
AKT1S1 interacts with AKT1 through a protein-protein interaction. AKT1S1 contains a binding domain that recognizes specific regions on AKT1, allowing them to interact and form a complex. This interaction inhibits the activity of AKT1 kinase and regulates its downstream signaling.
The role of AKT1S1 as an oncogene or tumor suppressor is still not fully understood and may vary depending on the context. While some studies suggest that AKT1S1 can act as a tumor suppressor by inhibiting AKT1 activity and suppressing cell growth and proliferation, other studies indicate that AKT1S1 can have oncogenic properties. Mutations in AKT1S1 have been found in certain cancers, including endometrial cancer, which suggests that aberrant AKT1S1 function may contribute to tumorigenesis. Further research is needed to clarify the exact role of AKT1S1 in cancer development and progression.
AKT1S1 protein is regulated through multiple mechanisms. One of the key modes of regulation is phosphorylation. Phosphorylation of specific sites on AKT1S1 can either positively or negatively regulate its interaction with AKT1.
Currently, there are no specific drugs or compounds that directly target AKT1S1 for therapeutic purposes. However, considering its role in regulating AKT1 activity and downstream signaling, targeting AKT1 itself through selective inhibitors may indirectly affect AKT1S1 function.
AKT1S1 plays a role in cell growth and proliferation by regulating the activity of AKT1. AKT1 is a kinase that promotes cell survival and growth by activating various downstream signaling pathways. AKT1S1, when bound to AKT1, inhibits its kinase activity and suppresses cell growth and proliferation. However, upon phosphorylation by mTORC1, AKT1S1 dissociates from AKT1, allowing AKT1 to become active and stimulate cell growth and proliferation.
AKT1S1 plays a role in the regulation of autophagy, a cellular process involved in the degradation and recycling of damaged or unnecessary cellular components. AKT1S1 can influence autophagy through its interaction with AKT1 and mTORC1. When AKT1S1 is phosphorylated by mTORC1, it dissociates from AKT1, resulting in AKT1 activation. Activated AKT1, in turn, inhibits autophagy by suppressing the activity of ULK1 (Unc-51-like autophagy-activating kinase 1), a key kinase involved in the initiation of autophagy.
In addition to the processes mentioned earlier, AKT1S1 is also involved in the regulation of insulin signaling and glucose metabolism. Insulin activates AKT1, which, in turn, phosphorylates AKT1S1, leading to its dissociation from AKT1. This allows AKT1 to promote glucose uptake and metabolism in cells. AKT1S1 has also been implicated in the regulation of lipid metabolism and adipogenesis, particularly through its interaction with mTORC1 and peroxisome proliferator-activated receptor gamma (PPARγ).
The dysregulation of AKT1S1 has been implicated in various diseases, including cancer and metabolic disorders. Therefore, targeting AKT1S1 could have therapeutic implications.
Customer Reviews (4)
Write a reviewthe AKT1S1 protein has proven to be an invaluable tool in protein electron microscopy structure analysis.
I highly recommend the AKT1S1 protein for a variety of research applications.
Great performance in ELISA.
It demonstrates excellent performance in ELISA, consistently delivering accurate and reliable results.
Ask a Question for All AKT1S1 Products
Required fields are marked with *
My Review for All AKT1S1 Products
Required fields are marked with *
Inquiry Basket