Recombinant Human ALOX5 Protein


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Recombinant Human ALOX5 Protein

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Cat.No. : ALOX5-64H
Product Overview : Recombinant human ALOX5(1-674) protein without tag was expressed in insect cells.
Description : This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : Insect cells
Species : Human
Molecular Mass : 78 kDa
Protein length : 1-674
Unit Definition : One unit of enzyme consumes one nmol of oxygen per minute at 25 centigrade in 50 mM Tris-HCl buffer, pH 7.5, containing 100 μM arachidonate, 2 mM CaCl2, 1 mM ATP, 4.6 μM 13(S)-HpODE, and 250 μM oxygen. 5-Lipoxygenase activity is measured at 25 centigrade by monitoring oxygen consumption using a Gilson Model 5/6 H oxygraph equipped with a Clark oxygen electrode.
Stability : ≥ 6 months
Storage : Store it at -80 centigrade
Storage Buffer : A clarified lysate, in 100 mM Tris-HCl, pH 8.0, containing 5 mM EGTA, 1mM CaCl2, and 30% glycerol
Gene Name : ALOX5 arachidonate 5-lipoxygenase [ Homo sapiens (human) ]
Official Symbol : ALOX5
Synonyms : ALOX5; arachidonate 5-lipoxygenase; 5-LO; 5LPG; LOG5; 5-LOX; polyunsaturated fatty acid 5-lipoxygenase; arachidonate 5-lipoxygenase; LOX-5; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase
Gene ID : 240
mRNA Refseq : NM_000698
Protein Refseq : NP_000689
MIM : 152390
UniProt ID : P09917
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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