Recombinant Human ATP2C2 Protein, His-tagged
|Product Overview :||Recombinant Human ATP2C2 Protein (Met1-Tyr106) with N-His tag was expressed in E. coli.|
- Gene Information
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|Description :||Enables P-type calcium transporter activity and P-type manganese transporter activity. Predicted to be involved in calcium ion transmembrane transport; cellular calcium ion homeostasis; and manganese ion transport. Predicted to act upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum; and plasma membrane. Predicted to be integral component of membrane.|
|Source :||E. coli|
|Form :||Freeze-dried powder|
|Molecular Mass :||Predicted Molecular Mass: 15.8 kDa
Accurate Molecular Mass: 19 kDa
|Protein length :||Met1-Tyr106|
|Purity :||> 90%|
|Applications :||Positive Control; Immunogen; SDS-PAGE; WB.|
|Stability :||The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.|
|Storage :||Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.|
|Storage Buffer :||PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300.|
|Reconstitution :||Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.|
|Gene Name :||ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 [ Homo sapiens (human) ]|
|Official Symbol :||ATP2C2|
|Synonyms :||AT2C2_HUMAN; ATP2C2; ATPase 2C2; ATPase, Ca++ transporting, type 2C, member 2; Calcium-transporting ATPase type 2C member 2; DKFZp686H22230; KIAA0703; Secretory pathway Ca(2+)-ATPase 2; ATP2C2; SPCA2|
|Gene ID :||9914|
|mRNA Refseq :||NM_014861|
|Protein Refseq :||NP_055676|
|UniProt ID :||O75185|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
ATP2C2 maintains calcium homeostasis in cardiomyocytes, and mutation of ATP2C2 may lead to abnormal myocardial systolic function, which in turn is associated with cardiovascular diseases such as myocardial infarction.
ATP2C2 plays a role in physiological processes such as intracellular regulation of calcium ion concentration, cytoskeletal assembly, neurotransmitter release, muscle contraction, and cell proliferation.
Mutation of ATP2C2 may lead to the dysfunction of ATP2C2, and then affect the intracellular calcium balance, neurotransmitter release and other key processes in the nervous system, leading to the occurrence of nervous system diseases.
Mutations in ATP2C2 may be associated with neurological diseases such as Alzheimer's disease, cardiovascular diseases such as myocardial infarction, metabolic disorders, and cancer.
Given the important role of ATP2C2 in multiple physiological processes, studying its disease-related mutations and calcium regulation mechanism may provide new clues and directions for the treatment of related diseases.
This is responsible for the transport and regulation of intracellular calcium ions during neurotransmitter release, ensuring that neurotransmitters can be released correctly into the synaptic cleft.
Customer Reviews (3)Write a review
Since the protein has a short half-life, it is more potent and less likely to cause side effects compared to other similar proteins. -
Protein manufacturers consistently produce products of the highest quality with a firm commitment to purity, potency, and consistency. -
ATP2C2 manufacturer's commitment to environmental sustainability is evident in its production processes, using green and renewable resources. -
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