Recombinant Rat ATP2C2 Protein, His (Fc)-Avi-tagged

• Cat.No.: ATP2C2-521R
• Product Overview: Recombinant Rat ATP2C2 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His&Fc&Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Atp2c2 ATPase, Ca++ transporting, type 2C, member 2 [ Rattus norvegicus ]
• Official Symbol: ATP2C2
• Gene ID: 171496
• mRNA Refseq: NM_134462.1
• Protein Refseq: NP_604457.1
• UniProt ID: Q8R4C1

Reviews

03/24/2020

Since the protein has a short half-life, it is more potent and less likely to cause side effects compared to other similar proteins.

09/24/2019

Protein manufacturers consistently produce products of the highest quality with a firm commitment to purity, potency, and consistency.

03/24/2019

ATP2C2 manufacturer's commitment to environmental sustainability is evident in its production processes, using green and renewable resources.

Q&As

What is the link between ATP2C2 and cardiovascular disease?

ATP2C2 maintains calcium homeostasis in cardiomyocytes, and mutation of ATP2C2 may lead to abnormal myocardial systolic function, which in turn is associated with cardiovascular diseases such as myocardial infarction.

In what physiological processes does ATP2C2 function?

ATP2C2 plays a role in physiological processes such as intracellular regulation of calcium ion concentration, cytoskeletal assembly, neurotransmitter release, muscle contraction, and cell proliferation.

How do mutations in ATP2C2 cause neurological diseases?

Mutation of ATP2C2 may lead to the dysfunction of ATP2C2, and then affect the intracellular calcium balance, neurotransmitter release and other key processes in the nervous system, leading to the occurrence of nervous system diseases.

What diseases may be caused by ATP2C22 mutations?

Mutations in ATP2C2 may be associated with neurological diseases such as Alzheimer's disease, cardiovascular diseases such as myocardial infarction, metabolic disorders, and cancer.

Does ATP2C2 have a potential therapeutic role?

Given the important role of ATP2C2 in multiple physiological processes, studying its disease-related mutations and calcium regulation mechanism may provide new clues and directions for the treatment of related diseases.

What is the specific role of ATP2C2 in neurotransmitter release?

This is responsible for the transport and regulation of intracellular calcium ions during neurotransmitter release, ensuring that neurotransmitters can be released correctly into the synaptic cleft.