| Cat.No. : |
BCL2A1-862H |
| Product Overview : |
Recombinant Human BCL2A1(Met1-Ser152), transcript variant 2, was expressed in E. coli. |
| Description : |
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
E. coli |
| Species : |
Human |
| Form : |
20mM Phosphate buffer, 150mM NaCl, 1mM EDTA, 1mM DTT, 10% Glycerol, pH 7.4. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. |
| Molecular Mass : |
18.5 kDa |
| Endotoxin : |
< 0.1 EU per µg protein as determined by LAL test |
| Purity : |
>95% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration : |
>50 ug/mL as determined by microplate BCA method |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.