| Description : |
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
77.8 kDa |
| AA Sequence : |
MDTKSILEELLLKRSQQKKKMSPNN YKERLFVLTKTNLSYYEYDKMKRGS RKGSIEIKKIRCVEKVNLEEQTPVE RQYPFQIVYKDGLLYVYASNEESRS QWLKALQKEIRGNPHLLVKYHSGFF VDGKFLCCQQSCKAAPGCTLWEAYA NLHTAVNEEKHRVPTFPDRVLKIPR AVPVLKMDAPSSSTTLAQYDNESKK NYGSQPPSSSTSLAQYDSNSKKIYG SQPNFNMQYIPREDFPDWWQVRKLK SSSSSEDVASSNQKERNVNHTTSKI SWEFPESSSSEEEENLDDYDWFAGN ISRSQSEQLLRQKGKEGAFMVRNSS QVGMYTVSLFSKAVNDKKGTVKHYH VHTNAENKLYLAENYCFDSIPKLIH YHQHNSAGMITRLRHPVSTKANKVP DSVSLGNGIWELKREEITLLKELGS GQFGVVQLGKWKGQYDVAVKMIKEG SMSEDEFFQEAQTMMKLSHPKLVKF YGVCSKEYPIYIVTEYISNGCLLNY LRSHGKGLEPSQLLEMCYDVCEGMA FLESHQFIHRDLAARNCLVDRDLCV KVSDFGMTRYVLDDQYVSSVGTKFP VKWSAPEVFHYFKYSSKSDVWAFGI LMWEVFSLGKQPYDLYDNSQVVLKV SQGHRLYRPHLASDTIYQIMYSCWH ELPEKRPTFQQLLSSIEPLREKDKH TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
