Recombinant Human BMX Non-receptor Tyrosine Kinase, Active

• Cat.No.: BMX-654H

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: The BMX gene encodes a non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells. The BMX gene is located on chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. BMX, is found to induce activation of the Stat signaling pathway.
• Biochem/physiol Actions: The BMX gene encodes a novel non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells. Bmx induces the activation of the Stat-signaling pathway.
• Unit Definition: Kinase activity is measured as the molar amount of phosphate incorporated into Poly Glu-Tyr substrate per minute per mg protein at 30 °C using a final concentration of 50 μM [32P]-ATP.
• Physical Form: Solution of 50 μL in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, and 30% glycerol.
• Assay: ≥85% (SDS-PAGE).
• Form: buffered aqueous glycerol solution.
• Mol Wt: apparent mol wt ~110 kDa.
• Storage Temp: −70°C.
• Pathways: Apoptosis

Gene Information

• Gene Name: BMX BMX non-receptor tyrosine kinase [ Homo sapiens ]
• Synonyms: BMX non-receptor tyrosine kinase; ETK; PSCTK2; PSCTK3; BMX; OTTHUMP00000022965; NTK38 tyrosine kinase; Etk/Bmx cytosolic tyrosine kinase; cytoplasmic tyrosine-protein kinase BMX; EC 2.7.10.2; NTK38; OTTHUMP00000022964; OTTHUMP00000022966; Epithelial and endothelial tyrosine kinase; Bone marrow tyrosine kinase gene in chromosome X protein
• Gene ID: 660
• mRNA Refseq: NM_001721
• Protein Refseq: NP_001712
• MIM: 300101
• UniProt ID: P51813
• Chromosome Location: Xp22.2
• Function: non-membrane spanning protein tyrosine kinase activity; ATP binding; metal ion binding; nucleotide binding; protein binding; signal transducer activity; transferase activity; zinc ion binding