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Recombinant Human Bone Morphogenetic Protein-2

Cat.No. : BMP2-22H
Product Overview : Recombinant Human Bone Morphogenetic Protein-2 produced inCHOis a homodimeric, glycosylated, Polypeptide chain containing 115 amino acids and having a calculated molecular mass of 26018 Dalton. Due to its glycosilation, BMP-2 migrates on SDS-PAGE under non-reducing conditions at 36kDa and 18kDa under reducing conditions. The BMP-2 CHO derived protein is purified by proprietary chromatographic techniques.
  • Specification
  • Gene Information
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Cat. No. : BMP2-22H
Description : BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.
Source : Chinese Hamster Ovary Cell.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation : 1mcg of BMP-2 was lyophilized from a sterile solution containing 0.2% sucrose, 2.5% glycine, 0.01% tween-80, 0.01% NaCl and 3% mannitol.
Biological Activity : The ED50as determined by cytolysis of ATDC-5 cell is less than 50ng/ml.
Solubility : It is recommended to reconstitute the lyophilized Bone Morphogenetic Protein-2 in sterile water at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions.
Purity : Greater than 95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.
Stability : Lyophilized Bone Morphogenetic Protein-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Gene Name : BMP2 bone morphogenetic protein 2 [ Homo sapiens ]
Synonyms : BMP2A; BMP-2; Bone morphogenetic protein 2 precursor;bone morphogenetic protein 5; BMP-2A; OTTHUMP00000016650; BMP2
Gene ID : 650
mRNA Refseq : NM_001200
Protein Refseq : NP_001191
MIM : 112261
UniProt ID : P12643
Chromosome Location : 20p12
Pathway : BMP signaling pathway; Basal cell carcinoma; Cytokine-cytokine receptor interaction; Hedgehog signaling pathway; TGF-beta signaling pathway
Function : Cytokine activity, Growth factor activity, Specific transcriptional repressor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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