Recombinant Human C7 Protein, GST-Tagged

• Cat.No.: C7-0129H
• Product Overview: Human C7 full-length ORF (BAG35608.1, 1 a.a. - 843 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 119.9 kDa
• AA Sequence: MKVISLFILVGFIGEFQSFSSASSP VNCQWDFYAPWSECNGCTKTQTRRR SVAVYGQYGGQPCVGNAFETQSCEP TRGCPTEEGCGERFRCFSGQCISKS LVCNGDSDCDEDSADEDRCEDSERR PSCDIDKPPPNIELTGNGYNELTGQ FRNRVINTKSFGGQCRKVFSGDGKD FYRLSGNVLSYTFQVKINNDFNYEF YNSTWSYVKHTSTEHTSSSRKRSFF RSSSSSSRSYTSHTNEIHKGKSYQL LVVENTVEVAQFINNNPEFLQLAEP FWKELSHLPSLYDYSAYRRLIDQYG THYLQSGSLGGEYRVLFYVDSEKLK QNDFNSLEEKKCKSSGWHFVVKFSS HGCKELENALKAASGTQNNVLRGEP FIRGGGAGFISGLTYLELDNPAGNK RRYSAWAESVTNLPQVIKQKLTPLY ELVKEVPCASVKKLYLKWALEEYLD EFDPCHCRPCQNGGLATVEGTHCLC HCKPYTFGAACEQGVLVGNQAGGVD GGWSCWSSWSPCVQGKKTRSRECNN PPPSGGGRSCVGETTESTQCEDEEL EHLRLLEPHCFPLSLVPTEFCPSPP ALKDGFVQDEGTMFPVGKNVVYTCN EGYSLIGNPVARCGEDLRWLVGEMH CQKIACVLPVLMDGIQSHPQKPFYT VGEKVTVSCSGGMSLEGPSAFLCGS SLKWSPEMKNARCVQKENPLTQAVP KCQRWEKLQNSRCVCKMPYECGPSL DVCAQDERSKRILPLTVCKMHVLHC QGRNYTLTGRDSCTLPASAEKACGA CPLWGKCDAESSKCVCREASECEEE GFSICVEVNGKEQTMSECEAGALRC RGQSISVTSIRPCAAETQ
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: C7 complement component 7 [ Homo sapiens ]
• Official Symbol: C7
• Synonyms: C7; complement component 7; complement component C7
• Gene ID: 730
• mRNA Refseq: NM_000587
• Protein Refseq: NP_000578
• MIM: 217070
• UniProt ID: P10643