Recombinant Human CCL7, StrepII-tagged

• Cat.No.: CCL7-291H
• Product Overview: Purified, full-length human recombinant CCL7 (MCP3) protein (amino acids 24-99, 76 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 9.0 kDa. (Accession NP_006264; UniProt P80098)

Specification

• Description: CCL7 is a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the CC subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. It augments monocyte anti-tumor activity and induces the release of gelatinase B. This protein can bind heparin, CCR1, CCR2, and CCR3.
• Source: Human Cells
• Species: Human
• Tag: StrepII
• Form: Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free)
• Protein length: 24-99, 76 a.a.
• AA Sequence: QPVGINTSTTCCYRFINKKIPKQRL ESYRRTTSSHCPREAVIFKTKLDKE ICADPTQKWVQDFMKHLDKKTQTPK L
• Endotoxin: <0.1 eu per μg protein by lal
• Purity: >90% by SDS-PAGE
• Storage: 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles.
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml

Gene Information

• Gene Name: CCL7 chemokine (C-C motif) ligand 7 [ Homo sapiens ]
• Official Symbol: CCL7
• Synonyms: CCL7; chemokine (C-C motif) ligand 7; SCYA6, SCYA7, small inducible cytokine A7 (monocyte chemotactic protein 3); C-C motif chemokine 7; FIC; MARC; MCP 3; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; NC28; small-inducible cytokine A7; small inducible cytokine A7 (monocyte chemotactic protein 3); MCP-3; SCYA6; SCYA7; MGC138463; MGC138465
• Gene ID: 6354
• mRNA Refseq: NM_006273
• Protein Refseq: NP_006264
• MIM: 158106
• UniProt ID: P80098
• Chromosome Location: 17q11.2-q12
• Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; GPCR ligand binding, organism-specific biosystem
• Function: CCR1 chemokine receptor binding; chemokine activity; heparin binding