CCL7
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Official Full Name
chemokine (C-C motif) ligand 7 -
Overview
Murine MCP-3, also known as Monocyte Chemotactic Protein 3 or C-C Motif Chemokine 7, is a 97 amino acid cytokine protein expressed from the Ccl7 gene located on chromosome 11. After initial synthesis and translocation, the 23 residue signal sequence is cleaved, allowing for the 74 residue MCP-3 peptide to properly fold and mature. MCP-3 is essentially a chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Moreover, the monomeric member of the intercrine beta (chemokine C-C) family tends to augment monocyte anti-tumor activity as well. -
Synonyms
RP23-350G1.4;MCP-3;Scya7;fic;marc;mcp3;C-C motif chemokine 7;RANTES/sis homolog;intercrine/chemokine MARC;monocyte chemoattractant protein 3;monocyte chemotactic protein 3;small inducible cytokine A7;small-inducible cytokine A7
Recombinant Proteins
- Mouse
- Human
- Rat
- E.coli
- CHO
- Wheat Germ
- Mammalian Cells
- Human
- HEK293
- Human Cells
- In Vitro Cell Free System
- Non
- His
- Fc
- GST
- T7
- Flag
- Avi
Involved Pathway
CCL7 involved in several pathways and played different roles in them. We selected most pathways CCL7 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | GSK3B,CXCL13,CX3CR1,HRAS,NFKB1,CXCR6,CCL14,PIK3R1,GNG13,RAP1A |
| Cytokine-cytokine receptor interaction | IL21,IL8L1,IL24,CXCL12,CCR10,IFNA21,IFNG,CXCR4,GH1,CXCR4A |
Protein Function
CCL7 has several biochemical functions, for example, CCR1 chemokine receptor binding,CCR2 chemokine receptor binding,chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL7 itself. We selected most functions CCL7 had, and list some proteins which have the same functions with CCL7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR2 chemokine receptor binding | Ccl12,CCL2 |
| protein binding | CDA,TTC39B,F11R,PIAS2,CCDC110,CDK9,LGALS1,BTBD1,PPP2R2A,MYLIP |
| CCR1 chemokine receptor binding | CCL5,CCL4,CCL3,CCL23,CREB3 |
| heparin binding | WISP1B,PTPRFB,GM4980,PCOLCE2,RSPO1,NRP2,MPO,THBS2,FGFR2,VEGFAA |
| chemokine activity | CCL23,CXCL6,Ccl12,CCL20,CXCL1,CCL22,CCL38A.4,CXCL10,CCL21B,CCL27B |
Interacting Protein
CCL7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL7.
UBQLN1;UBQLN1;AES;FEZ1
Resources
Research Area
Inflammatory MediatorsCytokines and Growth Factors Secreted by VSMC
Th22 Cells
CC Chemokines
Related Services
Related Products
References
- Kitase, Y; Lee, S; et al. CCL7 Is a Protective Factor Secreted by Mechanically Loaded Osteocytes. JOURNAL OF DENTAL RESEARCH 93:1108-1115(2014).
- Mercer, PF; Williams, AE; et al. Proteinase-Activated Receptor-1, CCL2, and CCL7 Regulate Acute Neutrophilic Lung Inflammation. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 50:144-157(2014).
