Recombinant Human CD-95, His Tag

Cat.No. : CDA074P
Product Overview : Recombinant FAS antigen/ CD95 purified from E. coli is a single non-glycosilated polypeptide chain containing amino acids 157-320 of Fas antigen (base pairs 713-1190 of cDNA sequence). The recombinant CD95 is fused to C-terminal 6-histidine amino acids. The FAS antigen is purified by proprietary chromatographic techniques.
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Cat. No. : CDA074P
Description : FAS/CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system.
Source : Escherichia Coli.
Physical Appearance : Sterile liquid formulation.
Purity : Greater than 95% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : 8M urea, 20mM Tris-HCl, pH-8.0, 0.2M Imidazole, 0.01M β-ME.
Storage : CD95 although stable at 10°C for 5 days, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Synonyms : CD95; CD-95; Tumor necrosis factor receptor superfamily member 6; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95 antigen; FAS; APT1; FAS1; TNFRSF6; APO-1; FASTM; ALPS1A; CD95; Fas (TNF receptor superfamily, member 6); tumor necrosis factor receptor superfamily, member 6; Fas AMA; Fas antigen; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; apoptosis antigen 1; APO-1 cell surface antigen; tumor necrosis factor receptor superfamily member 6; FAIM2; LFG; NMP35; Apoptosis-mediating surface antigen FAS; FASLG receptor; Fas (TNF receptor superfamily, member 6).
Synonyms : CD95; CD-95; Tumor necrosis factor receptor superfamily member 6; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95 antigen; FAS; APT1; FAS1; TNFRSF6; APO-1; FASTM; ALPS1A; CD95; Fas (TNF receptor superfamily, member 6); tumor necrosis factor receptor superfamily, member 6; Fas AMA; Fas antigen; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; apoptosis antigen 1; APO-1 cell surface antigen; tumor necrosis factor receptor superfamily member 6; FAIM2; LFG; NMP35; Apoptosis-mediating surface antigen FAS; FASLG receptor; Fas (TNF receptor superfamily, member 6).

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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09/07/2022

    When experimenting with FAS, the results are very reproducible.

    07/29/2022

      The stability of FAS products allows them to cope with different experimental conditions and modes of operation.

      09/20/2021

        FAS has high specific activity and can exert strong biological effect at low concentration.

        Q&As (6)

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        Does FAS protein play a role in cell signaling? 10/30/2022

        FAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.

        Why apply knowledge of FAS proteins to clinical practice? 06/27/2022

        It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.

        How can diseases associated with FAS protein be prevented and treated? 05/13/2022

        FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.

        How can gene knockout or knockdown techniques be used to study the function of FAS proteins? 03/31/2021

        Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.

        What is the role of FAS protein in apoptosis? 09/29/2020

        FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.

        How can FAS protein be used to predict disease prognosis? 06/19/2020

        The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.

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