Recombinant Human CD33 Protein (Asp18-His259), C-hFc and 6×His-tagged
Cat.No. : | CD33-501H |
Product Overview : | Recombinant Human CD33 Protein (Asp18-His259) with C-hFc and 6×His tag was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K. |
Source : | HEK293 |
Species : | Human |
Tag : | C-hFc and 6×His |
Form : | Lyophilized |
Molecular Mass : | 53.8 kDa |
Protein Length : | Asp18-His259 |
Purity : | > 95% as determined by SDS-PAGE and Coomassie blue staining. |
Storage : | Store at -80 centigrade for 12 months (Avoid repeated freezing and thawing) |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 44 % trehalose is added as protectants before lyophilization. |
Gene Name : | CD33 CD33 molecule [ Homo sapiens (human) ] |
Official Symbol : | CD33 |
Synonyms : | CD33; CD33 molecule; CD33 antigen (gp67); myeloid cell surface antigen CD33; FLJ00391; p67; sialic acid binding Ig like lectin 3; SIGLEC 3; SIGLEC3; gp67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC-3; |
Gene ID : | 945 |
mRNA Refseq : | NM_001082618 |
Protein Refseq : | NP_001076087 |
MIM : | 159590 |
UniProt ID : | P20138 |
Products Types
◆ Recombinant Protein | ||
CD33-670H | Recombinant Human CD33 Protein, His-tagged | +Inquiry |
CD33-240H | Recombinant Human CD33 Protein, hIgG-His-tagged | +Inquiry |
Cd33-5169M | Recombinant Mouse Cd33 protein(Met1-Glu240), His-tagged | +Inquiry |
CD33-190H | Recombinant Human CD33 Protein, His-tagged | +Inquiry |
Cd33-671R | Recombinant Rat Cd33 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CD33-978HCL | Recombinant Human CD33 cell lysate | +Inquiry |
CD33-1808MCL | Recombinant Mouse CD33 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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