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Recombinant Human CD40 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated

Cat.No. : CD40-174HAF647
Product Overview : Alexa Fluor 647 conjugated recombinant human CD40 extracellular domainhuman (Met 1-Arg193) (NP_001241.1), fused with the polyhistidine-tagged Fc region of human IgG1 at the C-terminus, was produced in Human Cell.
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Source : HEK293
Species : Human
Tag : Fc/His
Form : Lyophilized
Molecular Mass : The recombinant human CD40/Fc is a disulfide-linked homodimer. The reduced monomer consists of 421 amino acids and has a predicted molecular mass of 47.3 kDa. As a result of glycosylation, the apparent molecular mass of rhCD40/Fc monomer migrates with an apparent molecular mass of 55-60 kDa in SDS-PAGE under reducing conditions.
Protein length : 421
Endotoxin : < 1.0 EU/ μg of the protein as determined by the LAL method.
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 647 via amines
Excitation = 650 nm
Emission = 668 nm
Stability : Samples are stable for up to 12 months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 to -70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Gene Name : CD40 CD40 molecule, TNF receptor superfamily member 5 [ Homo sapiens ]
Official Symbol : CD40
Gene ID : 958
mRNA Refseq : NM_001250
Protein Refseq : NP_001241
MIM : 109535
UniProt ID : P25942

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can CD40-targeted therapies be used in the treatment of infectious diseases? 05/31/2022

CD40 agonists have the potential to enhance immune responses against infectious agents, but their clinical use in this context is an area of ongoing research.

Are there any approved drugs targeting CD40 for clinical use? 05/07/2021

As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting CD40. However, clinical trials were ongoing for CD40-targeted therapies.

Can CD40-targeted therapies be used in combination with other cancer treatments? 04/24/2019

Yes, CD40-targeted therapies are often investigated in combination with other treatments like checkpoint inhibitors or chemotherapy to enhance their effectiveness.

What are the potential side effects of CD40-targeted therapies in cancer treatment? 09/25/2018

Side effects may include flu-like symptoms, cytokine release syndrome, and immune-related adverse events, which can be managed with supportive care and close monitoring.

Are there ongoing clinical trials exploring CD40-targeted therapies for atherosclerosis? 04/25/2017

Research on CD40-targeted therapies for atherosclerosis is still in the experimental stages and not yet in advanced clinical trials.

Customer Reviews (3)

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10/28/2021

    Its utilization in this technique has allowed for precise visualization and determination of protein structures with remarkable clarity and resolution.

    08/11/2021

      The reliable and high-quality results obtained using CD40 protein make it an excellent choice for researchers studying protein structures.

      10/07/2018

        CD40 protein has proved to be an invaluable tool in protein electron microscopy structure analysis.

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