Recombinant Human CD55 Protein (Asp35-Gly285), His tagged
Cat.No. : | CD55-1046H |
Product Overview : | Recombinant human CD55 (Asp35-Gly285) fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
- Download
Description : | CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 3 SCRs (short consensus repeats) in their plasma-exposed regions. It is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. CD55 is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. This 7-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 30.09 kDa |
Protein Length : | Asp35-Gly285 |
Purity : | >90% as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) [ Homo sapiens (human) ] |
Official Symbol : | CD55 |
Synonyms : | CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group); DAF, decay accelerating factor for complement (CD55, Cromer blood group system); complement decay-accelerating factor; CR; CROM; TC; CD55 antigen; DAF; |
Gene ID : | 1604 |
mRNA Refseq : | NM_000574 |
Protein Refseq : | NP_000565 |
MIM : | 125240 |
UniProt ID : | P08174 |
Products Types
◆ Recombinant Protein | ||
CD55-01H | Recombinant Human CD55 Protein (35-353aa), C-His-tagged | +Inquiry |
CD55-64H | Active Recombinant Human CD55 protein(Met1-Ser353), hFc-tagged | +Inquiry |
CD55-689H | Recombinant Human CD55 Protein, His-tagged | +Inquiry |
Cd55-6893M | Recombinant Mouse Cd55 protein(Met1-Thr361), His-tagged | +Inquiry |
CD55-2325H | Recombinant Human CD55 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
CD55-1433RCL | Recombinant Rat CD55 cell lysate | +Inquiry |
CD55-2531HCL | Recombinant Human CD55 cell lysate | +Inquiry |
CD55-1669MCL | Recombinant Mouse CD55 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewEfficient shipping and exceptional product quality. This company knows how to serve its customers.
Consistency is key in research, and this product delivers that every time.
We've tried various proteins, but this one stands out for its purity and performance.
Q&As (5)
Ask a questionGenetic variations in CD55 may influence susceptibility to complement-mediated disorders by affecting the protein's ability to regulate complement activation. This can lead to conditions like paroxysmal nocturnal hemoglobinuria (PNH).
CD55 has immunomodulatory functions beyond complement regulation, influencing T cell responses and contributing to the maintenance of immune tolerance.
CD55 protects cells from complement-mediated lysis by preventing the formation of membrane attack complexes. This contributes to immune evasion by pathogens and self-cells alike.
CD55 consists of extracellular domains responsible for interactions with complement proteins, particularly C3b and C4b. These interactions prevent the formation of membrane attack complexes on host cells.
CD55 dysregulation is associated with autoimmune disorders, where it may contribute to immune system overactivity. Additionally, some pathogens exploit CD55 to evade host immune responses.
Ask a Question for All CD55 Products
Required fields are marked with *
My Review for All CD55 Products
Required fields are marked with *
Inquiry Basket