Recombinant Human CD95
Cat.No. : | CDA093P |
Product Overview : | Recombinant Human CD95 protein encoding a.a.2290-2491 expressed in E.coli,50 kDa. |
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Cat. No. : | CDA093P |
Description : | Fas/CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system. |
Source : | E.coli. |
Presentation : | Recombinant Human CD95 also called FAS protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. |
Applications : | •ELISA•Inhibition Assays •Western Blotting |
Characterization : | On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 50 kDa. |
Storage : | Store vial at -200℃ to -800°C. When stored at the recommended temperature, this protein is stable for 12 months. |
Tag : | Non |
Protein length : | 2290-2491 |
Synonyms : | FAS; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6; FAIM2; LFG; NMP35; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; APO-1 cell surface antigen; Apo-1 antige; Apoptosis-mediating surface antigen FAS; CD95 antigen; FASLG receptor; Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; apoptosis antigen 1; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6. |
Synonyms : | FAS; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6; FAIM2; LFG; NMP35; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; APO-1 cell surface antigen; Apo-1 antige; Apoptosis-mediating surface antigen FAS; CD95 antigen; FASLG receptor; Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; apoptosis antigen 1; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6. |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewWhen experimenting with FAS, the results are very reproducible.
The stability of FAS products allows them to cope with different experimental conditions and modes of operation.
FAS has high specific activity and can exert strong biological effect at low concentration.
Q&As (6)
Ask a questionFAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.
It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.
FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.
Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.
FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.
The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.
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