| Description : |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
91.5 kDa |
| AA Sequence : |
MGLPRGPLASLLLLQVCWLQCAASE PCRAVFREAEVTLEAGGAEQEPGQA LGKVFMGCPGQEPALFSTDNDDFTV RNGETVQERRSLKERNPLKIFPSKR ILRRHKRDWVVAPISVPENGKGPFP QRLNQLKSNKDRDTKIFYSITGPGA DSPPEGVFAVEKETGWLLLNKPLDR EEIAKYELFGHAVSENGASVEDPMN ISIIVTDQNDHKPKFTQDTFRGSVL EGVLPGTSVMQMTATDEDDAIYTYN GVVAYSIHSQEPKDPHDLMFTIHRS TGTISVISSGLDREKVPEYTLTIQA TDMDGDGSTTTAVAVVEILDANDNA PMFDPQKYEAHVPENAVGHEVQRLT VTDLDAPNSPAWRATYLIMGGDDGD HFTITTHPESNQGILTTRKGLDFEA KNQHTLYVEVTNEAPFVLKLPTSTA TIVVHVEDVNEAPVFVPPSKVVEVQ EGIPTGEPVCVYTAEDPDKENQKIS YRILRDPAGWLAMDPDSGQVTAVGT LDREDEQFVRNNIYEVMVLAMDNGS PPTTGTGTLLLTLIDVNDHGPVPEP RQITICNQSPVRQVLNITDKDLSPH TSPFQAQLTDDSDIYWTAEVNEEGD TVVLSLKKFLKQDTYDVHLSLSDHG NKEQLTVIRATVCDCHGHVETCPGP WKGGFILPVLGAVLALLFLLLVLLL LVRKKRKIKEPLLLPEDDTRDNVFY YGEEGGGEEDQDYDITQLHRGLEAR PEVVLRNDVAPTIIPTPMYRPRPAN PDEIGNFIIENLKAANTDPTAPPYD TLLVFDYEGSGSDAASLSSLTSSAS DQDQDYDYLNEWGSRFKKLADMYGG GEDDTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
