Recombinant Human CDK4/CCND2 Protein (M1-E303/E2-L289), GST/Flag/His-tagged
Cat.No. : | CDK4/CCND2-1617H |
Product Overview : | Recombinant Human N-GST-3C-CDK4(1-303end)/pFastBac1-Flag-8His-TEV-Cyclin D2(E2-L289 end) protein with a GST/Flag/His was expressed in Insect cell |
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Description : | Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3; G1/S-specific cyclin-D2 Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. |
Source : | Insect cell |
Species : | Human |
Tag : | GST/Flag/His |
Form : | Liquid |
Protein Length : | M1-E303/E2-L289 |
Endotoxin : | < 0.01 EU/μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM HEPES (pH 7.5), 150 mM NaCl, 5% glycerol. |
Shipping : | It is shipped out with blue ice. |
Gene Name : | CDK4 cyclin-dependent kinase 4 [ Homo sapiens (human) ] |
Official Symbol : | CDK4 |
Synonyms : | Cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3; G1/S-specific cyclin-D2 |
Gene ID : | 1019 |
mRNA Refseq : | NM_000075 |
Protein Refseq : | NP_000066 |
MIM : | 123829 |
UniProt ID : | P11802 |
Products Types
◆ Recombinant Protein | ||
CDK4/CCND2-1618H | Recombinant Human CDK4/CCND2 Protein (M1-E303/E2-L289) | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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