Recombinant Human Chemokine (C-C motif) Ligand 22

Cat.No. : CCL22-1874H
Product Overview : Recombinant HumanCCL22 is a 8.0 kDa protein containing 67 amino acid residues. Its molecularweight is 8000 Dalton.
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Cat. No. : CCL22-1874H
Description : CCL22 is a proteinthat in humans is encoded by the CCL22 gene. The protein encoded by this geneis secreted by dendritic cells and macrophages, and elicits its effects onits target cells by interacting with cell surface chemokine receptors such asCCR4. The gene for CCL22 is located in human chromosome 16 in a cluster withother chemokines called CX3CL1 and CCL17.
Source : E. coli
Species : Human
Form : Lyophilized
Molecular Weight : 8.0 kDa
Purity : Greater than 99% bySDS-PAGE and HPLC analyses.
Endotoxin Level : < 0.1 ng/µg ofMDC
Biological Activity : Determined by achemotaxis assay using human T-cells. Significant chemotaxis was achievedusing a concentration of 10.0-100 ng/ml.
Reconstitution : Centrifuge vialprior to opening. The lyophilized MDC is soluble in water and most aqueousbuffers. The lyophilized human MDC can be reconstituted in water to aconcentration of 1.0 mg/ml. This solution can be diluted into other bufferedsolutions or stored frozen at -20°C for future use.
Storage : Thelyophilized protein, though stable at room temperature, is best storeddesiccated below 0°C. Reconstituted MDC should be stored in working aliquotsat -20°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : CCL22
Gene Name : CCL22 chemokine (C-C motif) ligand 22 [Homo sapiens ]
Synonyms : CCL22; chemokine(C-C motif) ligand 22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; MGC34554;A-152E5.1; small inducible cytokine A22; CC chemokine STCP-1;macrophage-derived chemokine; stimulated T cell chemotactic protein 1; smallinducible cytokine subfamily A (Cys-Cys), member 22; Macrophage-derivedchemokine; Small-inducible cytokine A22; Stimulated T-cell chemotacticprotein 1; MDC(1-69)
Gene ID : 6367
mRNA Refseq : NM_002990
Protein Refseq : NP_002981
MIM : 602957
UniProt ID : O00626
Chromosome Location : 16q13
Pathway : Chemokine receptorsbind chemokines; Chemokine signaling pathway; Cytokine-cytokine receptorinteraction; Class A/1 (Rhodopsin-like receptors); GPCR ligand binding;Peptide ligand-binding receptors; Signal Transduction; Signaling by GPCR
Function : chemokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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05/01/2022

    The catalytic activity of CCL22 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and has high application value.

    03/13/2022

      This repeatability of CCL22 is very good, which can ensure the safety of the experiment and avoid unnecessary risks.

      08/25/2019

        CCL22 were well suited for our research needs due to their simple storage conditions and long-term preservation.

        Q&As (6)

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        What are the gene expression regulatory mechanisms of CCL22 protein? 11/23/2019

        The expression of CCL22 gene is regulated by a variety of signaling pathways, including inflammatory factor-mediated signaling pathways, cytokine-mediated signaling pathways, and transcription factors.

        What is the potential application value of CCL22 protein in treatment? 09/30/2019

        Studies have shown that by interfering with the interaction of the CCL22 protein and its receptor CCR4, tumor growth, improve inflammatory response, and regulate autoimmune diseases can be inhibited. These findings provide potential application value for the development of corresponding therapeutic strategies.

        Are there inhibitors or antagonists that interact with the CCL22 protein? 08/04/2019

        A number of inhibitors or antagonists that interact with CCL22 proteins have been developed that block the binding of CCL22 to its receptor CCR4, thereby interfering with its biological function.

        How to study the mechanism of action of CCL22 protein in specific diseases? 06/02/2019

        The mechanism of action of CCL22 protein in specific diseases can be studied through cell culture experiments, animal models, clinical samples, and related biochemical techniques.

        How does the CCL22 protein relate to other chemokines? 04/10/2019

        There are complex interactions between CCL22 proteins and other chemokines. They may influence the migration and localization of immune cells by competing for receptors, mutual regulation of expression, etc.

        What is the role of CCL22 protein in tumor immunotherapy? 03/08/2019

        Some studies have shown that in tumor immunotherapy, inhibiting the expression of CCL22 or interfering with its interaction with CCR4 can enhance the effect of immunotherapy and improve the survival rate of patients.

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