CCL22 Protein


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Official Full Name CCL22 chemokine (C-C motif) ligand 22
Background This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.
Synonyms CCL22; chemokine (C-C motif) ligand 22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; MGC34554; A-152E5.1; C-C motif chemokine 22; MDC(1-69); OTTHUMP00000164658; CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22
    • Species :
    • Cattle
    • Dog
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • In Vitro Cell Free System
    • Wheat Germ
    • Tag :
    • Biotin
    • Fc
    • GST
    • His
    • Myc/DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCL22-18H Recombinant Human CCL22, HIgG1 Fc-tagged CHO Fc
    Human CCL22-1900H Recombinant Human CCL22, MIgG2a Fc-tagged CHO Fc
    Human CCL22-3862H Recombinant Human Chemokine (C-C motif) Ligand 22, HIgG1 Fc-tagged, mutant CHO Fc
    Mouse CCL22-1678M Recombinant Mouse CCL22, MIgG2a Fc-tagged CHO Fc
    Mouse CCL22-3861M Recombinant Mouse Chemokine (C-C motif) Ligand 22, MIgG2a Fc-tagged, mutant CHO Fc
    Human CCL22-0627H Recombinant Human CCL22 Protein, GST-Tagged Wheat Germ GST
    Human CCL22-112H Recombinant Human Chemokine (C-C Motif) Ligand 22, His-tagged E.coli His
    Human CCL22-136H Recombinant Human CCL22, Fc-tagged CHO Fc
    Human CCL22-1874H Recombinant Human Chemokine (C-C motif) Ligand 22 E.coli N/A
    Human CCL22-29602TH Recombinant Human CCL22 E.coli N/A
    Human CCL22-29753TH Recombinant Human CCL22, His-tagged E.coli His
    Human CCL22-67H Recombinant Human CCL22 protein E.coli N/A
    Human CCL22-702H Recombinant Human CCL22 protein, His & GST-tagged E.coli His/GST
    Mouse Ccl22-91M Recombinant Mouse Ccl22 protein E.coli N/A
    Mouse CCL22-978M Recombinant Mouse CCL22 Protein, His-tagged E.coli His
    Rat Ccl22-637R Recombinant Rat Ccl22 protein E.coli N/A
    Rat Ccl22-703R Recombinant Rat Ccl22 protein, His & GST-tagged E.coli His/GST
    Dog CCL22-701D Recombinant Dog CCL22 protein, His & GST-tagged E.coli His/GST
    Cattle CCL22-700C Recombinant Cattle CCL22 protein, His & GST-tagged E.coli His/GST
    Human CCL22-7728HCL Recombinant Human CCL22 293 Cell Lysate HEK293 N/A
    Pig CCL22-1108P Recombinant Pig CCL22 Protein, His-tagged E.coli N-His
    Human CCL22-151H Recombinant Human CCL22 Protein, His-tagged Human Cells His
    Human CCL22-2930HF Recombinant Full Length Human CCL22 Protein, GST-tagged In Vitro Cell Free System GST
    Human CCL22-49H Recombinant Human CCL22 Protein E.coli
    Human CCL22-5227H Recombinant Human CCL22 protein, GST-tagged E.coli GST
    Human CCL22-63H Recombinant Human CCL22 Protein, Biotin-tagged E.coli Biotin
    Human CCL22-311H Recombinant Human CCL22 Protein, His-tagged E.coli His
    Mouse Ccl22-131M Recombinant Mouse Ccl22 Protein E.coli
    Mouse Ccl22-2034M Recombinant Mouse Ccl22 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse CCL22-2884M Recombinant Mouse CCL22 Protein E.coli N/A
    Mouse CCL22-2887M Recombinant Mouse Ccl22 Protein E.coli N/A

    CCL22 involved in several pathways and played different roles in them. We selected most pathways CCL22 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction VEGFA; Il23a; FLT1; CCL4; CCR9A; TNFRSF10D; CXCL10; XCL1; FLT3; BMP2
    Chemokine signaling pathway CCR9; RAP1B; GNG10; GM10591; GNG13; CXCL11; Adcy4; CCL21B; CCL3; CCL26

    CCL22 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL22 itself. We selected most functions CCL22 had, and list some proteins which have the same functions with CCL22. You can find most of the proteins on our site.

    Function Related Protein
    CCR chemokine receptor binding CCL20; CCL16; CCL20B; CCL20A.3; CCL19B; CCL18; CCRL2; CCL24; CCL38A.4; CCL13
    chemokine activity CCL6; CXCL5; CCL35.2; CCL25B; CCL24; CCL33.3; PPBP; CCL25; CXCL10; CXCL11

    CCL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL22.


    Yoshie, O; Matsushima, K; et al. CCR4 and its ligands: from bench to bedside. INTERNATIONAL IMMUNOLOGY 27:11-20(2015).
    Hernandez-Bedolla, MA; Carretero-Ortega, J; et al. Chemotactic and proangiogenic role of calcium sensing receptor is linked to secretion of multiple cytokines and growth factors in breast cancer MDA-MB-231 cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853:166-182(2015).

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