This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.
CCL22; chemokine (C-C motif) ligand 22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; MGC34554; A-152E5.1; C-C motif chemokine 22; MDC(1-69); OTTHUMP00000164658; CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22;
CCL22 involved in several pathways and played different roles in them. We selected most pathways CCL22 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
CCL22 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL22 itself. We selected most functions CCL22 had, and list some proteins which have the same functions with CCL22. You can find most of the proteins on our site.
CCL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL22.
DPP4; CRYAB; GCLC; HERC3
Yoshie, O; Matsushima, K; et al. CCR4 and its ligands: from bench to bedside. INTERNATIONAL IMMUNOLOGY 27:11-20(2015).
Hernandez-Bedolla, MA; Carretero-Ortega, J; et al. Chemotactic and proangiogenic role of calcium sensing receptor is linked to secretion of multiple cytokines and growth factors in breast cancer MDA-MB-231 cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853:166-182(2015).