CCL22

  • Official Full Name

    CCL22 chemokine (C-C motif) ligand 22

  • Overview

    This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.
  • Synonyms

    CCL22; chemokine (C-C motif) ligand 22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; MGC34554; A-152E5.1; C-C motif chemokine 22; MDC(1-69); OTTHUMP00000164658; CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Cattle
  • Dog
  • Human
  • Mouse
  • Pig
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Wheat Germ
  • Biotin
  • Fc
  • GST
  • His
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL22-3862H Active Recombinant Human Chemokine (C-C motif) Ligand 22, HIgG1 Fc-tagged, mutant CHO Fc
Human CCL22-18H Active Recombinant Human CCL22, HIgG1 Fc-tagged CHO Fc
Human CCL22-1900H Active Recombinant Human CCL22, MIgG2a Fc-tagged CHO Fc
Human CCL22-1874H Recombinant Human Chemokine (C-C motif) Ligand 22 E.coli N/A
Human CCL22-67H Recombinant Human CCL22 protein E.coli N/A 69
Human CCL22-29753TH Recombinant Human CCL22, His-tagged E.coli His
Human CCL22-112H Recombinant Human Chemokine (C-C Motif) Ligand 22, His-tagged E.coli His
Human CCL22-702H Recombinant Human CCL22 protein, His & GST-tagged E.coli His/GST Gly25~Gln93 (Accession # O00626)
Human CCL22-136H Recombinant Human CCL22, Fc-tagged CHO Fc
Human CCL22-0627H Recombinant Human CCL22 Protein, GST-Tagged Wheat Germ GST
Human CCL22-29602TH Recombinant Human CCL22 E.coli N/A
Human CCL22-7728HCL Recombinant Human CCL22 293 Cell Lysate HEK293 N/A
Human CCL22-081C Active Recombinant Human CCL22 Protein (69 aa) E.coli 69
Human CCL22-5227H Recombinant Human CCL22 protein, GST-tagged E.coli GST 25-82aa
Human CCL22-311H Recombinant Human CCL22 Protein, His-tagged E.coli His Gly 25-Gln 93
Human CCL22-151H Recombinant Human CCL22 Protein, His-tagged Human Cells His
Human CCL22-082C Active Recombinant Human CCL22 Protein (68 aa) E.coli 68
Human CCL22-49H Recombinant Human CCL22 protein E.coli N/A 1-69aa
Human CCL22-1268H Recombinant Human CCL22 Protein (Gly25-Gln93), N-GST tagged E.coli N-GST Gly25-Gln93
Human CCL22-63H Recombinant Human CCL22 Protein, Biotin-tagged E.coli Biotin
Human CCL22-2930HF Recombinant Full Length Human CCL22 Protein, GST-tagged In Vitro Cell Free System GST 93 amino acids
Mouse CCL22-3861M Active Recombinant Mouse Chemokine (C-C motif) Ligand 22, MIgG2a Fc-tagged, mutant CHO Fc
Mouse CCL22-1678M Active Recombinant Mouse CCL22, MIgG2a Fc-tagged CHO Fc
Mouse CCL22-978M Recombinant Mouse CCL22 protein, His-tagged E.coli His Gly26-Ser92
Mouse Ccl22-91M Recombinant Mouse Ccl22 protein E.coli N/A 68
Mouse CCL22-2884M Recombinant Mouse CCL22 Protein E.coli N/A
Mouse CCL22-2887M Active Recombinant Mouse Ccl22 Protein E.coli N/A
Mouse Ccl22-131M Active Recombinant Mouse Ccl22 Protein E.coli
Mouse Ccl22-2034M Recombinant Mouse Ccl22 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ccl22-042C Active Recombinant Mouse Ccl22 Protein (68 aa) E.coli 68
Rat Ccl22-637R Recombinant Rat Ccl22 protein E.coli N/A 68
Rat Ccl22-703R Recombinant Rat Ccl22 protein, His & GST-tagged E.coli His/GST Tyr27~Ala92 (Accession # Q91ZH5)
Dog CCL22-701D Recombinant Dog CCL22 protein, His & GST-tagged E.coli His/GST Met1~Pro93 (Accession # XM_003433778.1)
Cattle CCL22-700C Recombinant Cattle CCL22 protein, His & GST-tagged E.coli His/GST Met1~Gln93 (Accession # NM_001099162.1)
Pig CCL22-1108P Recombinant Pig CCL22 Protein, His-tagged E.coli N-His Gly25-Gln93
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CCL22 involved in several pathways and played different roles in them. We selected most pathways CCL22 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIFNA17;CXCL10;CRLF2;HGF;MPL;KITB;TNFSF11;TNFRSF8;CX3CR1
Chemokine signaling pathwayRAP1B;CCL2;CCL4;GM10591;RELA;CCL16;CCL7;AMCF-II;PF4

CCL22 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL22 itself. We selected most functions CCL22 had, and list some proteins which have the same functions with CCL22. You can find most of the proteins on our site.

Function Related Protein
CCR chemokine receptor bindingCCL38.1;CCL26;CCL8;XCL2;CCL44;CCL15;CCL24;CCL35.1;CCL19A.2
chemokine activityCXCL6;CCL1;Ccl9;CCL39.1;CCL8;CCL19B;CXCL13;CX3CL1;CCL33.3

CCL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL22.

DPP4; CRYAB; GCLC; HERC3

Gene Family

Chemokines Cytokines

Research Area

Related articles

Yoshie, O; Matsushima, K; et al. CCR4 and its ligands: from bench to bedside. INTERNATIONAL IMMUNOLOGY 27:11-20(2015).
Hernandez-Bedolla, MA; Carretero-Ortega, J; et al. Chemotactic and proangiogenic role of calcium sensing receptor is linked to secretion of multiple cytokines and growth factors in breast cancer MDA-MB-231 cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853:166-182(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the gene expression regulatory mechanisms of CCL22 protein? 11/23/2019

The expression of CCL22 gene is regulated by a variety of signaling pathways, including inflammatory factor-mediated signaling pathways, cytokine-mediated signaling pathways, and transcription factors.

What is the potential application value of CCL22 protein in treatment? 09/30/2019

Studies have shown that by interfering with the interaction of the CCL22 protein and its receptor CCR4, tumor growth, improve inflammatory response, and regulate autoimmune diseases can be inhibited. These findings provide potential application value for the development of corresponding therapeutic strategies.

Are there inhibitors or antagonists that interact with the CCL22 protein? 08/04/2019

A number of inhibitors or antagonists that interact with CCL22 proteins have been developed that block the binding of CCL22 to its receptor CCR4, thereby interfering with its biological function.

How to study the mechanism of action of CCL22 protein in specific diseases? 06/02/2019

The mechanism of action of CCL22 protein in specific diseases can be studied through cell culture experiments, animal models, clinical samples, and related biochemical techniques.

How does the CCL22 protein relate to other chemokines? 04/10/2019

There are complex interactions between CCL22 proteins and other chemokines. They may influence the migration and localization of immune cells by competing for receptors, mutual regulation of expression, etc.

What is the role of CCL22 protein in tumor immunotherapy? 03/08/2019

Some studies have shown that in tumor immunotherapy, inhibiting the expression of CCL22 or interfering with its interaction with CCR4 can enhance the effect of immunotherapy and improve the survival rate of patients.

Customer Reviews (3)

Write a review
Reviews
05/01/2022

    The catalytic activity of CCL22 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and has high application value.

    03/13/2022

      This repeatability of CCL22 is very good, which can ensure the safety of the experiment and avoid unnecessary risks.

      08/25/2019

        CCL22 were well suited for our research needs due to their simple storage conditions and long-term preservation.

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