Recombinant Human CLCF1, His-tagged
Cat.No. : | CLCF1-29299TH |
Product Overview : | Recombinant full length Human NNT1 with an N terminal His tag; 219aa, 24.6kDa inclusive of tag. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Protein length : | 198 amino acids |
Conjugation : | HIS |
Molecular Weight : | 24.600kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | pH: 3.50Constituents:10% Glycerol, 2.4% Urea, 0.59% Sodium citrate |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMLNRT GDPGPGPSIQKTYDLTRYLEHQLRS LAGTYLNYLGPPFNEPDFNPPRLGA ETLPRATVDLEVWRSLNDKLRLTQN YEAYSHLLCYLRGLNRQAATAELRR SLAHFCTSLQGLLGSIAGVMAALGY PLPQPLPGTEPTWTPGPAHSDFLQK MDDFWLLKELQTWLWRSAKDFNRLK KKMQPPAAAVTLHLGAHGF |
Sequence Similarities : | Belongs to the IL-6 superfamily. |
Gene Name : | CLCF1 cardiotrophin-like cytokine factor 1 [ Homo sapiens ] |
Official Symbol : | CLCF1 |
Synonyms : | CLCF1; cardiotrophin-like cytokine factor 1; CRLF1 associated cytokine like factor 1; B cell stimulating factor 3; BSF 3; BSF3; CISS2; CLC; cold induced sweating syndrome 2; NNT 1; NNT1; novel neurotrophin 1; NR6; |
Gene ID : | 23529 |
mRNA Refseq : | NM_001166212 |
Protein Refseq : | NP_001159684 |
MIM : | 607672 |
Uniprot ID : | Q9UBD9 |
Chromosome Location : | 11q13.3 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
Function : | ciliary neurotrophic factor receptor binding; contributes_to ciliary neurotrophic factor receptor binding; contributes_to cytokine activity; cytokine activity; growth factor activity; |
Products Types
◆ Recombinant Protein | ||
CLCF1-618H | Recombinant Human CLCF1 Protein, His-tagged | +Inquiry |
CLCF1-3242H | Recombinant Human CLCF1 Protein, MYC/DDK-tagged | +Inquiry |
CLCF1-1413H | Recombinant Human CLCF1 Protein, GST-tagged | +Inquiry |
CLCF1-1716M | Recombinant Mouse CLCF1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Clcf1-2178M | Recombinant Mouse Clcf1 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
CLCF1-001HCL | Recombinant Human CLCF1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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