Recombinant Human CRYAB Protein, Myc/DDK-tagged

Cat.No. : CRYAB-01H
Product Overview : Recombinant protein of human crystallin, alpha B (CRYAB) with a C-Myc/DDK tag was expressed in HEK293T.
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Description : Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.
Source : HEK293T
Species : Human
Tag : Myc/DDK
Molecular Mass : 20 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
SDS-PAGE: Coomassie blue staining of purified CRYAB protein. The protein was produced from HEK293T cells transfected with CRYAB cDNA clone using MegaTran 2.0.
Gene Name : CRYAB crystallin alpha B [ Homo sapiens (human) ]
Official Symbol : CRYAB
Synonyms : CRYAB; crystallin alpha B; MFM2; CRYA2; CTPP2; HSPB5; CMD1II; CTRCT16; HEL-S-101; alpha-crystallin B chain; epididymis secretory protein Li 101; heat shock protein beta-5; heat-shock 20 kD like-protein; renal carcinoma antigen NY-REN-27; rosenthal fiber component
Gene ID : 1410
mRNA Refseq : NM_001885
Protein Refseq : NP_001876
MIM : 123590
UniProt ID : P02511

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