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Recombinant Human CSF1R protein (aa 543-922), His-GST-tagged

Cat.No. : CSF1R-1970H
Product Overview : Recombinant Human CSF1R (NP_005202.2) protein (Lys 543-Asp 922) is produced by Baculovirus-Insect Cells expression system. This protein is fused with a His-GST tag at the N-terminal.
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Source : Baculovirus-Insect Cells
Species : Human
Tag : His&GST
Predicted N Terminal : Met
Form : Supplied as sterile 50mM Tris, 100mM NaCl, 20% gly, 0.3mM DTT, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human CSF1R (aa 543-922) /GST chimera consists of 617 amino acids and has a calculated molecular mass of 71 KDa. It migrates as an approximately 60 KDa band in SDS-PAGE under reducing conditions.
Protein length : Lys 543-Asp 922
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 82 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles
Shipping : Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Gene Name : CSF1R colony stimulating factor 1 receptor [ Homo sapiens ]
Official Symbol : CSF1R
Synonyms : CSF1R; colony stimulating factor 1 receptor; C FMS; CD115; CSFR; CSF-1-R; CD115 antigen; FMS; FIM2; HDLS; C-FMS; CSF-1R; M-CSF-R;
Gene ID : 1436
mRNA Refseq : NM_005211
Protein Refseq : NP_005202
MIM : 164770
UniProt ID : P07333

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
01/09/2022

    With its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.

    10/30/2017

      This variety allows me to select the most appropriate option based on the specific requirements of my research.

      03/10/2017

        the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the CSF1R protein, which is essential for obtaining accurate and consistent results.

        Q&As (5)

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        Are there any FDA-approved drugs targeting CSF1R for clinical use? 07/20/2021

        Yes, drugs like pexidartinib have been approved for the treatment of certain rare tumors called tenosynovial giant cell tumors (TGCT) that overexpress CSF1R.

        How can CSF1R inhibitors impact the tumor microenvironment? 10/22/2018

        CSF1R inhibitors can modulate the tumor microenvironment by reducing the number of tumor-associated macrophages and promoting an anti-tumor immune response.

        Can CSF1R inhibitors be used in combination with other cancer treatments? 09/20/2018

        Yes, CSF1R inhibitors are often used in combination with chemotherapy and immunotherapy to enhance treatment effectiveness.

        What are the potential clinical applications of CSF1R inhibitors? 01/21/2017

        CSF1R inhibitors are being investigated for cancer therapy to block tumor-promoting macrophages and slow down cancer progression.

        Can CSF1R inhibitors be used to treat neurodegenerative diseases? 12/04/2016

        Research is ongoing, and CSF1R inhibitors are being explored as a potential therapy for neurodegenerative diseases, but no FDA-approved treatments currently exist.

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