Recombinant Human CSF1R Protein, hIgG-His-tagged

Cat.No. : CSF1R-001H
Product Overview : Recombinant human CSF1R, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Availability July 16, 2024
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Description : CSF1R, also known as macrophage colony-stimulating factor 1 receptor, is a member of the type 3 subfamily of receptor tyrosine kinases. It is expressed primarily on cells of the monocyte and macrophage lineage, stem cells, and in the developing placenta and mediates most of the biological effects of this cytokine. This protein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. CSF1 and this receptor were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role of CSF1/CSF1R in normal mammary gland development is very intriguing because this relationship has also been found in the biology of breast cancer in which abnormal expression of CSF1 and its receptor. Also, increased levels of CSF1R are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active.
Source : Insect cell
Species : Human
Tag : hIgG-His
Form : Liquid
Molecular Mass : 82.1 kDa
AASequence : IPVIEPSVPELVVKPGATVTLRCVG NGSVEWDGPPSPHWTLYSDGSSSIL STNNATFQNTGTYRCTEPGDPLGGS AAIHLYVKDPARPWNVLAQEVVVFE DQDALLPCLLTDPVLEAGVSLVRVR GRPLMRHTNYSFSPWHGFTIHRAKF IQSQDYQCSALMGGRKVMSISIRLK VQKVIPGPPALTLVPAELVRIRGEA AQIVCSASSVDVNFDVFLQHNNTKL AIPQQSDFHNNRYQKVLTLNLDQVD FQHAGNYSCVASNVQGKHSTSMFFR VVESAYLNLSSEQNLIQEVTVGEGL NLKVMVEAYPGLQGFNWTYLGPFSD HQPEPKLANATTKDTYRHTFTLSLP RLKPSEAGRYSFLARNPGGWRALTF ELTLRYPPEVSVIWTFINGSGTLLC AASGYPQPNVTWLQCSGHTDRCDEA QVLQVWDDPYPEVLSQEPFHKVTVQ SLLTVETLEHNQTYECRAHNSVGSG SWAFIPISAGAHTHPPDEFLFTPLE PKSCDKTHTCPPCPAPELLGGPSVF LFPPKPKDTLMISRTPEVTCVVVDV SHEDPEVKFNWYVDGVEVHNAKTKP REEQYNSTYRVVSVLTVLHQDWLNG KEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSRDELTKNQVSLT CLVKGFYPSDIAVEWESNGQPENNY KTTPPVLDSDGSFFLYSKLTVDKSR WQQGNVFSCSVMHEALHNHYTQKSL SLSPGKHHHHHH
N-terminal Sequence Analysis : Ile 20
Endotoxin : < 1.0 EU per 1 μg of protein (determined by LAL method)
Purity : > 90% by SDS - PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/mL (determined by Absorbance at 280nm)
Storage Buffer : In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Warning : For research use only. This product is not intended or approved for human, diagnostics or veterin
Gene Name : CSF1R colony stimulating factor 1 receptor [ Homo sapiens (human) ]
Official Symbol : CSF1R
Synonyms : CSF1R; colony stimulating factor 1 receptor; FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; macrophage colony-stimulating factor 1 receptor; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; McDonough feline sarcoma viral (v-fms) oncogene homolog; macrophage colony stimulating factor I receptor; proto-oncogene c-Fms; EC 2.7.10.1
Gene ID : 1436
mRNA Refseq : NM_005211
Protein Refseq : NP_005202
MIM : 164770
UniProt ID : P07333

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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01/09/2022

    With its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.

    10/30/2017

      This variety allows me to select the most appropriate option based on the specific requirements of my research.

      03/10/2017

        the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the CSF1R protein, which is essential for obtaining accurate and consistent results.

        Q&As (5)

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        Are there any FDA-approved drugs targeting CSF1R for clinical use? 07/20/2021

        Yes, drugs like pexidartinib have been approved for the treatment of certain rare tumors called tenosynovial giant cell tumors (TGCT) that overexpress CSF1R.

        How can CSF1R inhibitors impact the tumor microenvironment? 10/22/2018

        CSF1R inhibitors can modulate the tumor microenvironment by reducing the number of tumor-associated macrophages and promoting an anti-tumor immune response.

        Can CSF1R inhibitors be used in combination with other cancer treatments? 09/20/2018

        Yes, CSF1R inhibitors are often used in combination with chemotherapy and immunotherapy to enhance treatment effectiveness.

        What are the potential clinical applications of CSF1R inhibitors? 01/21/2017

        CSF1R inhibitors are being investigated for cancer therapy to block tumor-promoting macrophages and slow down cancer progression.

        Can CSF1R inhibitors be used to treat neurodegenerative diseases? 12/04/2016

        Research is ongoing, and CSF1R inhibitors are being explored as a potential therapy for neurodegenerative diseases, but no FDA-approved treatments currently exist.

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