Recombinant Human CSF1R Protein, hIgG-His-tagged

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Recombinant Human CSF1R Protein, hIgG-His-tagged

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Cat.No. : CSF1R-001H
Product Overview : Recombinant human CSF1R, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Description : CSF1R, also known as macrophage colony-stimulating factor 1 receptor, is a member of the type 3 subfamily of receptor tyrosine kinases. It is expressed primarily on cells of the monocyte and macrophage lineage, stem cells, and in the developing placenta and mediates most of the biological effects of this cytokine. This protein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. CSF1 and this receptor were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role of CSF1/CSF1R in normal mammary gland development is very intriguing because this relationship has also been found in the biology of breast cancer in which abnormal expression of CSF1 and its receptor. Also, increased levels of CSF1R are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active.
Source : Insect cell
Species : Human
Tag : hIgG-His
Form : Liquid
Molecular Mass : 82.1 kDa
AASequence : IPVIEPSVPE LVVKPGATVT LRCVGNGSVE WDGPPSPHWT LYSDGSSSIL STNNATFQNT GTYRCTEPGD PLGGSAAIHL YVKDPARPWN VLAQEVVVFE DQDALLPCLL TDPVLEAGVS LVRVRGRPLM RHTNYSFSPW HGFTIHRAKF IQSQDYQCSA LMGGRKVMSI SIRLKVQKVI PGPPALTLVP AELVRIRGEA AQIVCSASSV DVNFDVFLQH NNTKLAIPQQ SDFHNNRYQK VLTLNLDQVD FQHAGNYSCV ASNVQGKHST SMFFRVVESA YLNLSSEQNL IQEVTVGEGL NLKVMVEAYP GLQGFNWTYL GPFSDHQPEP KLANATTKDT YRHTFTLSLP RLKPSEAGRY SFLARNPGGW RALTFELTLR YPPEVSVIWT FINGSGTLLC AASGYPQPNV TWLQCSGHTD RCDEAQVLQV WDDPYPEVLS QEPFHKVTVQ SLLTVETLEH NQTYECRAHN SVGSGSWAFI PISAGAHTHP PDEFLFTPLE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH
N-terminal Sequence Analysis : Ile 20
Endotoxin : < 1.0 EU per 1 μg of protein (determined by LAL method)
Purity : > 90% by SDS - PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/mL (determined by Absorbance at 280nm)
Storage Buffer : In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Warning : For research use only. This product is not intended or approved for human, diagnostics or veterin
SDS-PAGE :

15% SDS-PAGE (3 μg)

Gene Name : CSF1R colony stimulating factor 1 receptor [ Homo sapiens (human) ]
Official Symbol : CSF1R
Synonyms : CSF1R; colony stimulating factor 1 receptor; FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; macrophage colony-stimulating factor 1 receptor; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; McDonough feline sarcoma viral (v-fms) oncogene homolog; macrophage colony stimulating factor I receptor; proto-oncogene c-Fms; EC 2.7.10.1
Gene ID : 1436
mRNA Refseq : NM_005211
Protein Refseq : NP_005202
MIM : 164770
UniProt ID : P07333

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