CSF1R
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Official Full Name
colony stimulating factor 1 receptor -
Overview
Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. M-CSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of thi -
Synonyms
CSF1R;colony stimulating factor 1 receptor;macrophage colony-stimulating factor 1 receptor;c-fms;CSF-1-R;CSF-1 receptor;proto-oncogene fms;proto-oncogene c-Fms;Fms;CD115;Csfmr;Fim-2;CSF-1R;M-CSFR;M-CSF-R;AI323359;CSFR;FIM2;HDLS
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Rat
- Rabbit
- Canine
- Cat
- Rhesus macaque
- HEK293
- Human Cells
- Insect Cells
- Mammalian Cells
- CHO
- Wheat Germ
- Sf9 Cells
- E.coli
- His
- Non
- Fc
- Avi
- mFc
- GST
- Flag
- DDK
- Myc
- SUMO
Involved Pathway
CSF1R involved in several pathways and played different roles in them. We selected most pathways CSF1R participated on our site, such as C-MYB transcription factor network,Cytokine-cytokine receptor interaction,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSF1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | TRAF3,Pdgfa&Pdgfb,ARNT2,LPAR2,WNT8A,FGF19,RARB,GNAI3,FZD7,ITGA3 |
| Integrins in angiogenesis | CSF1,ANGPTL3,MFGE8,EDIL3 |
| Endocytosis | MVB12B,SH3GLB2A,PIP5KL1,HRASB,F2R,SNX1A,ERBB3B,RAB11AL,ARPC5LA,ACAP3 |
| C-MYB transcription factor network | CDK6,MYF6,MYB,PPID,COL1A2,SMARCA2,CBX4,ELANE,MYOD1,CDKN1B |
| Osteoclast differentiation | FCGR3,GRB2,FOS,LILRA2,SIRPB1,STAT2,SIRPG,MAPK12,SPI1,PLCG2 |
| PI3K-Akt signaling pathway | CHAD,CSF1,PRP2,CSH2,EFNA3,EFNA4,CSF3,LAMC3,COMP,CDC37 |
| Cytokine-cytokine receptor interaction | CSF3R,TNFRSF19,TNFRSF9A,IL21,TGFBR1A,TGFB1A,CCR3,CXCL12B,CXCL10,TNFRSF17 |
| Hematopoietic cell lineage | GYPA,IL6R,CD37,CD3E; CD3D,IL3RA,KIT,CD33,EPOR,CD1E,IL7R |
Protein Function
CSF1R has several biochemical functions, for example, ATP binding,cytokine binding,macrophage colony-stimulating factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSF1R itself. We selected most functions CSF1R had, and list some proteins which have the same functions with CSF1R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | ASCL1,CHEK2,TRIM8,GSTM3,GYS2,DMRT1,GALE,STUB1,TERT,STOM |
| ATP binding | ADRBK1,NEK4,FPGS,PIK3C2A,RUNX2A,ACTB,PIF1,SCYL2,VPS4A,WARS |
| protein phosphatase binding | TP53,DLG3,EIF2AK3,KAT2A,Itga10&Itgb1,ROS1,TRP53,ANAPC7,JAK3,RPA3 |
| macrophage colony-stimulating factor receptor activity | MST1R |
| cytokine binding | IL31RA,KITA,KITB,CRLF1,CHRD,PARK7,TNFRSF11A,CXCR4,CNTFR,GBP1 |
Interacting Protein
CSF1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSF1R here. Most of them are supplied by our site. Hope this information will be useful for your research of CSF1R.
Plcg2;saicar;PKM;GRAP2;HSP90AB1;PIK3R1;yqeH;hppD;purL;Src;FYN;Fyn;Yes1
Resources
Research Area
Cancer Drug TargetsReceptor Tyrosine Kinases (RTKs)
Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
CD Antigen (Neutrophils)
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
CSF Receptor
Monocyte Markers
MDSC Phenotyping - Positive Markers
Oncoprotein-Growth Factor Receptors
Related Services
Related Products
References
- Shi, M; Movius, J; et al. Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation. MOLECULAR & CELLULAR PROTEOMICS 14:544-555(2015).
- Moffat, L; Rothwell, L; et al. Development and characterisation of monoclonal antibodies reactive with porcine CSF1R (CD115). DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 47:123-128(2014).
