CSF1R

  • Official Full Name

    colony stimulating factor 1 receptor

  • Overview

    Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. M-CSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of thi
  • Synonyms

    CSF1R; colony stimulating factor 1 receptor; macrophage colony-stimulating factor 1 receptor; c-fms; CSF-1-R; CSF-1 receptor; proto-oncogene fms; proto-oncogene c-Fms; Fms; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R; AI323359; CSFR; FIM2; HDLS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canine
  • Cat
  • Cynomolgus
  • Cynomolgus monkey
  • Human
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus
  • Baculovirus-Insect Cells
  • CHO cells
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • 6×His
  • Fc
  • His
  • mFc
  • Myc
  • DDK
  • DDK|His
  • Fc Chimera
  • Avi
  • Fc|His
  • Flag
  • GST
  • hFc
  • His (Fc)
  • His(C
  • ter)
  • His|Avi
  • His|GST
  • His|HIgG
  • His|SUMO
  • HlgG1 Fc
  • human|IgG1|Fc
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CSF1R-804H Active Recombinant Human CSF1R protein HEK293 N/A Met1-Glu512
Human CSF1R-469H Active Recombinant Human CSF1R, Fc Chimera Mammalian cells Fc Chimera
Human CSF1R-352H Active Recombinant Human CSF1R protein(Met1-Pro517), mFc-tagged HEK293 C-mFc Met1-Pro517
Human CSF1R-91H Active Recombinant Human CSF1R(538-end) Protein, N-His-tagged Sf21 His 538-end
Human CSF1R-051H Active Recombinant Human CSF1R protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Ile20-Thr516
Human CSF1R-47H Recombinant Active Human CSF1R Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Ile20-Glu512
Human CSF1R-1268H Active Recombinant Human CSF1R protein, His-tagged HEK293 His Ile20-Glu512
Human CSF1R-90H Active Recombinant Human CSF1R(Y969C)(538-end) Mutation Protein, N-His-tagged Sf21 His 538-end
Human CSF1R-192H Active Recombinant Human CSF1R Protein, His & GST-tagged Insect Cell His/GST
Human CSF1R-320H Recombinant Human CSF1R, GST-tagged, Active Sf9 Insect Cell GST
Human CSF1R-936H Recombinant Human CSF1R Protein, DDK-tagged Sf9 Insect Cell DDK
Human CSF1R-58H Recombinant Human CSF1R protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CSF1R-470H Recombinant Human CSF1R protein, Fc-tagged, low endotoxin HEK293 human/IgG1/Fc 493
Human CSF1R-935H Recombinant Human CSF1R Protein, DDK/His-tagged HEK293 DDK/His
Human CSF1R-021H Active Recombinant Human CSF1R protein, His-tagged HEK293 His Met1-Glu512
Human CSF1R-1965H Recombinant Human CSF1R Protein, GST-tagged Wheat Germ GST
Human CSF1R-49H Recombinant Human CSF1R protein, Flag-tagged, Biotinylated Insect Cell Flag
Human CSF1R-1666H Recombinant Human Colony Stimulating Factor 1 Receptor Mammalian cells N/A
Human CSF1R-28792TH Recombinant Human CSF1R N/A
Human CSF1R-1964H Active Recombinant Human CSF1R Protein, GST-tagged Insect Cell GST
Human CSF1R-39H Recombinant Human CSF1R, Fc-His tagged Human Cell Fc/His
Human CSF1R-805H Recombinant Human CSF1R protein, His-tagged HEK293 His Met1-Ser290
Human CSF1R-7031H Recombinant Human CSF1R protein, His-tagged E.coli His Phe768~Ser928 (Accession # P07333)
Human CSF1R-444HCL Recombinant Human CSF1R cell lysate Insect Cell N/A
Human CSF1R-2739HCL Recombinant Human CSF1R cell lysate Human Cell N/A
Human CSF1R-333H Recombinant Human CSF1R protein, His-Avi-tagged HEK293 His-Avi Ile 20-Glu 512
Human CSF1R-022H Active Recombinant Human CSF1R Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human CSF1R-806H Recombinant Human CSF1R protein (Ala299-Glu512), His-tagged HEK293 His
Human CSF1R-353H Active Recombinant Human CSF1R protein, mFc-tagged HEK293 mFc Ile 20 - Glu 512
Human CSF1R-020H Recombinant Human CSF1R Protein, C-His-tagged E.coli C-His
Human CSF1R-001H Recombinant Human CSF1R Protein, hIgG-His-tagged Insect Cell His/HIgG
Human CSF1R-067H Recombinant Human CSF1R Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CSF1R-1284H Recombinant Human CSF1R Protein, His&GST-tagged E.coli N-His&GST Val22-Pro401
Human CSF1R-1085HFL Recombinant Full Length Human CSF1R Protein, C-Flag-tagged Mammalian cells Flag
Human CSF1R-1970H Recombinant Human CSF1R protein (aa 543-922), His-GST-tagged Baculovirus-Insect Cells His/GST Lys 543-Asp 922
Human CSF1R-1826H Recombinant Human CSF1R Protein (20-512), His tagged E.coli His 20-512
Human CSF1R-373H Recombinant Human CSF1R Protein, His-tagged HEK293 His 972
Human CSF1R-180H Recombinant Human CSF1R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CSF1R-807H Recombinant Human CSF1R protein (Met1-Glu512) HEK293
Human CSF1R-0262H Active Recombinant Human CSF1R protein, hFc&Avi-tagged, Biotinylated HEK293 hFc&Avi Met1-Glu512
Human CSF1R-374H Recombinant Human CSF1R Protein, Fc-tagged HEK293 Fc 972
Human CSF1R-076H Recombinant Human CSF1R Protein (Ile20-Leu514), C-6×His-tagged HEK293 C-6×His Ile20-Leu514
Human Csf1r-774H Recombinant Human Csf1r Protein, His-tagged HEK293 His
Human CSF1R-1319H Recombinant Human CSF1R Protein (Y538-C972), Tag Free Insect Cell No tag Y538-C972
Human CSF1R-0512H Active Recombinant Human CSF1R protein, Fc-tagged HEK293 Fc Ile20-Glu512
Human CSF1R-1320S Recombinant Human CSF1R Protein (Y538-C972), GST tagged Insect Cell GST Y538-C972
Human CSF1R-180H-B Recombinant Human CSF1R Protein Pre-coupled Magnetic Beads HEK293
Human CSF1R-0898H Recombinant Human CSF1R Protein (Ile20-Glu512), N-His tagged E.coli N-His Ile20-Glu512
Human CSF1R-4029H Recombinant Human CSF1R Protein (Met1-Glu512), C-His tagged Mammalian cells C-His Met1-Glu512
Human CSF1R-4030H Recombinant Human CSF1R Protein (Ile20-Pro517), C-Fc tagged Mammalian cells C-Fc Ile20-Pro517
Human CSF1R-4031H Recombinant Human CSF1R Protein (Ile20-Pro517), C-His tagged Mammalian cells C-His Ile20-Pro517
Mouse Csf1r-4000M Active Recombinant Mouse Csf1r protein, His-tagged HEK293 His Met1-Ser511
Mouse Csf1r-337MB Active Recombinant Mouse Csf1r protein, His-tagged, Biotinylated HEK293 His
Mouse Csf1r-1966M Recombinant Mouse Csf1r Protein, GST-tagged Wheat Germ GST
Mouse Csf1r-7032M Recombinant Mouse Csf1r protein, His-tagged E.coli His Gly639~Lys868 (Accession # P09581)
Mouse Csf1r-337M Recombinant Mouse CSF1R protein(Met1-Ser511), His-tagged HEK293 C-His Met1-Ser511
Mouse Csf1r-8665M Recombinant Mouse Csf1r protein, Fc-tagged, low endotoxin HEK293 human/IgG1/Fc 492
Mouse Csf1r-8666M Recombinant Mouse Csf1r, Fc-His tagged Human Cell Fc/His
Mouse CSF1R-2091MCL Recombinant Mouse CSF1R cell lysate Human Cell N/A
Mouse Csf1r-375M Recombinant Mouse Csf1r Protein, His-tagged HEK293 His 977
Mouse Csf1r-4001M Active Recombinant Mouse Csf1r Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Mouse Csf1r-376M Recombinant Mouse Csf1r Protein, Fc-tagged HEK293 Fc 977
Mouse Csf1r-2339M Recombinant Mouse Csf1r Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CSF1R-0511M Active Recombinant Mouse CSF1R protein, Fc-tagged HEK293 Fc Ala20-Ser511
Mouse Csf1r-864M Recombinant Mouse Csf1r Protein, hFc-tagged HEK293 hFc Met1-Ser511
Rat Csf1r-535R Active Recombinant Rat Csf1r Protein, hFc-tagged HEK293 hFc Met1-Glu510
Rat Csf1r-55R Recombinant Rat Csf1r, His tagged Human Cell Fc/His
Rat Csf1r-54R Active Recombinant Rat Csf1r protein, His-tagged HEK293 His Met1-Glu510
Rat Csf1r-7033R Recombinant Rat Csf1r protein, His-tagged E.coli His Ser734~Thr900 (Accession # Q00495)
Rat CSF1R-823RCL Recombinant Rat CSF1R cell lysate Human Cell N/A
Rabbit CSF1R-347R Recombinant Rabbit CSF1R protein, His-tagged HEK293 His Val 20 - Ser 503
Canine CSF1R-427C Recombinant Canine CSF1R protein, His-tagged HEK293 His Val20-Pro510
Cat CSF1R-429C Recombinant Cat CSF1R Protein (20-514 aa), His-SUMO-tagged E.coli His/SUMO 20-514 aa
Cynomolgus CSF1R-0510C Active Recombinant Cynomolgus CSF1R protein, Fc-tagged HEK293 Fc Ile99-Pro596
Cynomolgus CSF1R-65C Recombinant Cynomolgus CSF1R protein, His-tagged HEK293 His 498
Cynomolgus CSF1R-346C Recombinant Cynomolgus CSF1R protein, Fc-tagged HEK293 human/IgG1/Fc 498
Cynomolgus monkey CSF1R-372C Recombinant Cynomolgus monkey CSF1R Protein, Fc-tagged HEK293 Fc 1055
Cynomolgus monkey CSF1R-371C Recombinant Cynomolgus monkey CSF1R Protein, His-tagged HEK293 His 1055
Rhesus CSF1R-979R Recombinant Rhesus CSF1R Protein (Met1-Glu512) (Cys378Arg), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Glu512
Rhesus CSF1R-980R Recombinant Rhesus CSF1R Protein (Met1-Glu512) (Cys378Arg), His-tagged HEK293 His Met1-Glu512
Kit-1574 CSF1R Kinase Binding Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CSF1R involved in several pathways and played different roles in them. We selected most pathways CSF1R participated on our site, such as C-MYB transcription factor network, Cytokine-cytokine receptor interaction, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSF1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
C-MYB transcription factor networkPTCRA;MYOD1;LECT2;SMARCA2;PRTN3;CEBPB;MYF6;ELANE;MYC
Cytokine-cytokine receptor interactionCCL3L1;TNFSF4;IFNA17;IFNA3;Flt3l;IL24;CXCR1;CXCL6;LIF
EndocytosisARF6A;RAB11BA;CHMP3;CAPZA3;RABEP1;SH3GL1A;TFR1A;KIF5B;RHOA
Hematopoietic cell lineageCD2;IL2RA;IL6R;IL1R2;ITGB3;CSF1R;CD3E;GP1BB;IL5RA
Integrins in angiogenesisEDIL3;ANGPTL3;CSF1;CSF1R;MFGE8
Osteoclast differentiationFCGR4;TNFRSF11B;FCGR2C;PIK3CD;IFNG;MAPK10;LILRA1;TNF;NFATC1
PI3K-Akt signaling pathwayPRP2;EFNA4;CSF1R;LAMC3;CHAD;PIK3AP1;CSH1;CSF3;SGK2
Pathways in cancerGNAI1;NOS2;CDH1;TRAF6;EGLN1;HSP90AB1;MAPK3;STK4;GNG8

CSF1R has several biochemical functions, for example, ATP binding, cytokine binding, macrophage colony-stimulating factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSF1R itself. We selected most functions CSF1R had, and list some proteins which have the same functions with CSF1R. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRIPK1;MET;TSSK3;MAP2K3;ABL2;ATP8B1;HELB;SMC5;MSH3
cytokine bindingFzd4;CSF1RA;CHRD;NOG;NRP1;KITB;CSF1R;CXCR4;NRP2
macrophage colony-stimulating factor receptor activityCSF1R;MST1R
protein homodimerization activityBMP2B;ATPIF1A;TSG101;ACOT7;HER5;SYT6;CRYBA2;CCBL1;PLDN
protein phosphatase bindingFGF19;CDH5;DRD1A;VCP;ERBB2;VCAN;JAK3;VRK3;STAT6

CSF1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSF1R here. Most of them are supplied by our site. Hope this information will be useful for your research of CSF1R.

Plcg2; saicar; PKM; GRAP2; HSP90AB1; PIK3R1; yqeH; hppD; purL; Src; FYN; Fyn; Yes1

Research Area

Related articles

Shi, M; Movius, J; et al. Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation. MOLECULAR & CELLULAR PROTEOMICS 14:544-555(2015).
Moffat, L; Rothwell, L; et al. Development and characterisation of monoclonal antibodies reactive with porcine CSF1R (CD115). DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 47:123-128(2014).
  • Q&As
  • Reviews

Q&As (5)

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Are there any FDA-approved drugs targeting CSF1R for clinical use? 07/20/2021

Yes, drugs like pexidartinib have been approved for the treatment of certain rare tumors called tenosynovial giant cell tumors (TGCT) that overexpress CSF1R.

How can CSF1R inhibitors impact the tumor microenvironment? 10/22/2018

CSF1R inhibitors can modulate the tumor microenvironment by reducing the number of tumor-associated macrophages and promoting an anti-tumor immune response.

Can CSF1R inhibitors be used in combination with other cancer treatments? 09/20/2018

Yes, CSF1R inhibitors are often used in combination with chemotherapy and immunotherapy to enhance treatment effectiveness.

What are the potential clinical applications of CSF1R inhibitors? 01/21/2017

CSF1R inhibitors are being investigated for cancer therapy to block tumor-promoting macrophages and slow down cancer progression.

Can CSF1R inhibitors be used to treat neurodegenerative diseases? 12/04/2016

Research is ongoing, and CSF1R inhibitors are being explored as a potential therapy for neurodegenerative diseases, but no FDA-approved treatments currently exist.

Customer Reviews (3)

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Reviews
01/09/2022

    With its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.

    10/30/2017

      This variety allows me to select the most appropriate option based on the specific requirements of my research.

      03/10/2017

        the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the CSF1R protein, which is essential for obtaining accurate and consistent results.

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